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Open AccessJournal ArticleDOI

Geographic Patterns of Genome Admixture in Latin American Mestizos

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TLDR
An analysis of admixture in thirteen Mestizo populations from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites found extensive variation in Native American and European ancestry among populations and individuals and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women.
Abstract
The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly European and Native settlement) from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites. We found extensive variation in Native American and European ancestry (and generally low levels of African ancestry) among populations and individuals, and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women. An admixture analysis allowing for Native American population subdivision revealed a differentiation of the Native American ancestry amongst Mestizos. This observation is consistent with the genetic structure of pre-Columbian populations and with admixture having involved Natives from the area where the Mestizo examined are located. Our findings agree with available information on the demographic history of Latin America and have a number of implications for the design of association studies in population from the region.

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Citations
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Journal ArticleDOI

Ancestral genetic legacy of the extant population of Argentina as predicted by autosomal and X-chromosomal DIPs

TL;DR: In this article, two sets of nuclear deletion/insertion polymorphisms (DIPs) including 30 located on autosomal chromosomes and 33 on the X chromosome were selected to determine their ancestry diagnostic potential, and the results showed that the European component was the largest (778%), followed by the Native American (179%) and African (42%) components.
Journal ArticleDOI

Influence of county-level geographic/ancestral origin on glioma incidence and outcomes in US Hispanics.

TL;DR: Glioma incidence and outcomes differ in association with the geographic origins of Hispanic communities, with counties of predominantly Mexican/Central-American-origin at significantly reduced risk and those of Caribbean- origin at comparatively greater risk.
Dissertation

Historia y estructura genética de la población de Costa Rica y su posible asociación con genes de susceptibilidad a enfermedades mentales

TL;DR: Tesis (magister scientiae en biologicia con enfasis en genetica y biologia molecular)--Universidad de Costa Rica.
DissertationDOI

Reconstructing Population Histories in Relation to Ecology

TL;DR: This analysis uses complete mtDNA genomes from over 1,700 individuals to explore changes in populations sizes in five populations for each of 4 major geographic regions, using a sophisticated coalescent-based Bayesian method (Extended Bayesian Skyline Plots) and mutation rates calibrated with ancient DNA.

Iconographies supplémentaires de l'article : Cosmopolitan and ethnic-specific replication of genetic risk factors for asthma in 2 Latino populations

TL;DR: In this article, the authors compared the pattern of replication of these associations in Puerto Ricans and Mexicans and found that only a minority of genetic association studies replicate in their population of Mexican and Puerto Rican asthmatic subjects.
References
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Journal ArticleDOI

Inference of population structure using multilocus genotype data

TL;DR: Pritch et al. as discussed by the authors proposed a model-based clustering method for using multilocus genotype data to infer population structure and assign individuals to populations, which can be applied to most of the commonly used genetic markers, provided that they are not closely linked.
Journal ArticleDOI

Inference of Population Structure Using Multilocus Genotype Data: Linked Loci and Correlated Allele Frequencies

TL;DR: Extensions to the method of Pritchard et al. for inferring population structure from multilocus genotype data are described and methods that allow for linkage between loci are developed, which allows identification of subtle population subdivisions that were not detectable using the existing method.
Journal ArticleDOI

Genetic Data Analysis II.

Bruce S. Weir
- 01 Mar 1997 - 
Journal ArticleDOI

Estimating African American admixture proportions by use of population-specific alleles.

TL;DR: Significant nonrandom association between two markers located 22 cM apart (FY-null and AT3) is detected, most likely due to admixture linkage disequilibrium created in the interbreeding of the two parental populations, emphasize the importance of admixed populations as a useful resource for mapping traits with different prevalence in two parental population.
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