Geographic Patterns of Genome Admixture in Latin American Mestizos
Sijia Wang,Nicolas Ray,Winston Rojas,María Victoria Parra,Gabriel Bedoya,Carla Gallo,Giovanni Poletti,Guido Mazzotti,Kim Hill,A. M. Hurtado,Beatriz Camrena,Humberto Nicolini,William Klitz,Ramiro Barrantes,Julio Molina,Nelson B. Freimer,Maria Cátira Bortolini,Francisco M. Salzano,Maria Luiza Petzl-Erler,Luiza T. Tsuneto,José E. Dipierri,Emma L. Alfaro,Graciela Bailliet,Néstor O. Bianchi,Elena Llop,Francisco Rothhammer,Francisco Rothhammer,Laurent Excoffier,Andres Ruiz-Linares +28 more
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TLDR
An analysis of admixture in thirteen Mestizo populations from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites found extensive variation in Native American and European ancestry among populations and individuals and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women.Abstract:
The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly European and Native settlement) from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites. We found extensive variation in Native American and European ancestry (and generally low levels of African ancestry) among populations and individuals, and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women. An admixture analysis allowing for Native American population subdivision revealed a differentiation of the Native American ancestry amongst Mestizos. This observation is consistent with the genetic structure of pre-Columbian populations and with admixture having involved Natives from the area where the Mestizo examined are located. Our findings agree with available information on the demographic history of Latin America and have a number of implications for the design of association studies in population from the region.read more
Citations
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Evaluation of group genetic ancestry of populations from Philadelphia and Dakar in the context of sex-biased admixture in the Americas.
Klara Stefflova,Matthew C. Dulik,Athma A. Pai,Amy H. Walker,Charnita Zeigler-Johnson,Serigne Magueye Gueye,Theodore G. Schurr,Timothy R. Rebbeck +7 more
TL;DR: Sex-biased admixture in African-derived populations is present throughout the Americas, with continual influence of European males, while Native American females contribute mainly to populations of the Caribbean and South America.
Journal ArticleDOI
Rheumatoid arthritis in Latin Americans enriched for Amerindian ancestry is associated with loci in chromosomes 1, 12, and 13, and the HLA class II region.
David López Herráez,Manuel Martínez-Bueno,Laura Riba,Ignacio García-De La Torre,Mónica P. Sacnun,Mario Goñi,Guillermo A. Berbotto,Sergio Paira,Jorge L. Musuruana,César Graf,Alejandro Alvarellos,Osvaldo D. Messina,Alejandra Babini,Ingrid Strusberg,Juan Carlos Marcos,Hugo R. Scherbarth,Alberto Spindler,Ana Quinteros,Sergio Toloza,José Luis C. Moreno,Luis J. Catoggio,Guillermo Tate,Alicia Eimon,Gustavo Citera,Antonio Catalán Pellet,G Nasswetter,Mario H. Cardiel,Pedro Miranda,Francisco J. Ballesteros,Jorge A. Esquivel-Valerio,Marco A. Maradiaga-Ceceña,Eduardo Acevedo-Vásquez,Conrado García García,Teresa Tusié-Luna,Bernardo A. Pons-Estel,Marta E. Alarcón-Riquelme,Marta E. Alarcón-Riquelme +36 more
TL;DR: The contribution of Amerindian ancestry to the genetic architecture of RA in an admixed Latin American population is defined for the first time by confirming the role of the HLA region and supporting the association with a locus in chromosome 1.
Journal ArticleDOI
Population structure in Argentina
Marina Muzzio,Marina Muzzio,Josefina María Brenda Motti,Paula B. Paz Sepúlveda,Muh-Ching Yee,Thomas F. Cooke,María Rita Santos,María Rita Santos,Virginia Ramallo,Emma L. Alfaro,José E. Dipierri,Graciela Bailliet,Claudio M. Bravi,Claudio M. Bravi,Carlos Bustamante,Eimear E. Kenny +15 more
TL;DR: There is a correlation between distance to Buenos Aires and proportion of Native American ancestry, where the highest proportion corresponds to the Northernmost populations, which is also the furthest from the Argentinian capital.
Journal ArticleDOI
A Comparative Analysis of Genetic Ancestry and Admixture in the Colombian Populations of Chocó and Medellín
Andrew B. Conley,Lavanya Rishishwar,Emily T. Norris,Augusto Valderrama-Aguirre,Leonardo Mariño-Ramírez,Miguel A Medina-Rivas,I. King Jordan +6 more
TL;DR: A comparative analysis of the genetic ancestry of Chocó, a state located on Colombia's Pacific coast with a population that is >80% Afro-Colombian, and six other admixed American populations, with an emphasis on a Mestizo population from the nearby Colombian city of Medellín, which shows overall patterns of subcontinental ancestry that are highly similar.
Journal ArticleDOI
Nation and the Absent Presence of Race in Latin American Genomics
Peter Wade,Vivette García Deister,Michael Kent,María Fernanda Olarte Sierra,Adriana Díaz del Castillo Hernández +4 more
TL;DR: In this article, the authors characterize race as an absent presence in Latin America and argue that genomics finds a particular expression of race through concepts of nation, because this vehicle suits the deep-rooted ambiguity of race in the region.
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