Geographic Patterns of Genome Admixture in Latin American Mestizos
Sijia Wang,Nicolas Ray,Winston Rojas,María Victoria Parra,Gabriel Bedoya,Carla Gallo,Giovanni Poletti,Guido Mazzotti,Kim Hill,A. M. Hurtado,Beatriz Camrena,Humberto Nicolini,William Klitz,Ramiro Barrantes,Julio Molina,Nelson B. Freimer,Maria Cátira Bortolini,Francisco M. Salzano,Maria Luiza Petzl-Erler,Luiza T. Tsuneto,José E. Dipierri,Emma L. Alfaro,Graciela Bailliet,Néstor O. Bianchi,Elena Llop,Francisco Rothhammer,Francisco Rothhammer,Laurent Excoffier,Andres Ruiz-Linares +28 more
Reads0
Chats0
TLDR
An analysis of admixture in thirteen Mestizo populations from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites found extensive variation in Native American and European ancestry among populations and individuals and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women.Abstract:
The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly European and Native settlement) from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites. We found extensive variation in Native American and European ancestry (and generally low levels of African ancestry) among populations and individuals, and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women. An admixture analysis allowing for Native American population subdivision revealed a differentiation of the Native American ancestry amongst Mestizos. This observation is consistent with the genetic structure of pre-Columbian populations and with admixture having involved Natives from the area where the Mestizo examined are located. Our findings agree with available information on the demographic history of Latin America and have a number of implications for the design of association studies in population from the region.read more
Citations
More filters
"The Genetic Ancestry of African Americans, Latinos, and European Americans Across the United States" data files
TL;DR: It is shown that regional ancestry differences reflect historical events, such as early Spanish colonization, waves of immigration from many regions of Europe, and forced relocation of Native Americans within the US, which informs the understanding of the relationship between racial and ethnic identities and genetic ancestry.
Journal ArticleDOI
Genome-wide patterns of population structure and admixture among Hispanic/Latino populations
Katarzyna Bryc,Christopher Velez,Tatiana M. Karafet,Andrés Moreno-Estrada,Andrés Moreno-Estrada,Andrew R. Reynolds,Adam Auton,Adam Auton,Michael F. Hammer,Carlos Bustamante,Carlos Bustamante,Harry Ostrer +11 more
TL;DR: The results suggest future genome-wide association scans in Hispanic/Latino populations may require correction for local genomic ancestry at a subcontinental scale when associating differences in the genome with disease risk, progression, and drug efficacy, as well as for admixture mapping.
Journal ArticleDOI
Health Disparities in the Latino Population
TL;DR: The demographic structure of the Latino population is examined and how nativity, age, income, and education are related to observed patterns of health and mortality and the utility of the public health social inequality framework and the status syndrome for explaining Latino disparities is discussed.
Journal ArticleDOI
Analysis of genomic diversity in Mexican Mestizo populations to develop genomic medicine in Mexico
Irma Silva-Zolezzi,Alfredo Hidalgo-Miranda,Jesus K. Estrada-Gil,Juan Carlos Fernández-López,Laura Uribe-Figueroa,Alejandra V. Contreras,Eros Balam-Ortiz,Laura del Bosque-Plata,David Velázquez-Fernández,Cesar Lara,Rodrigo Goya,Enrique Hernández-Lemus,Carlos Davila,Eduardo Barrientos,Santiago March,Gerardo Jimenez-Sanchez +15 more
TL;DR: The notion that a haplotype map of the Mexican Mestizo population can reduce the number of tag SNPs required to characterize common genetic variation in this population is supported.
Journal ArticleDOI
Admixture in Latin America: Geographic Structure, Phenotypic Diversity and Self-Perception of Ancestry Based on 7,342 Individuals
Andres Ruiz-Linares,Kaustubh Adhikari,Victor Acuña-Alonzo,Mirsha Quinto-Sánchez,Claudia Jaramillo,William Arias,Macarena Fuentes,María Pizarro,Paola Everardo,Francisco de Avila,Jorge Gómez-Valdés,Paola León-Mimila,Tábita Hünemeier,Virginia Ramallo,Caio Cesar Silva de Cerqueira,M. W. Burley,Esra Konca,Marcelo Zagonel de Oliveira,Mauricio Roberto Veronez,Marta Rubio-Codina,Orazio Attanasio,Sahra Gibbon,Nicolas Ray,Carla Gallo,Giovanni Poletti,Javier Rosique,Lavinia Schuler-Faccini,Francisco M. Salzano,Maria Cátira Bortolini,Samuel Canizales-Quinteros,Francisco Rothhammer,Gabriel Bedoya,David J. Balding,Rolando González-José +33 more
TL;DR: The geographic distribution of admixture proportions in this sample reveals extensive population structure, illustrating the continuing impact of demographic history on the genetic diversity of Latin America.
References
More filters
Journal ArticleDOI
Inference of population structure using multilocus genotype data
TL;DR: Pritch et al. as discussed by the authors proposed a model-based clustering method for using multilocus genotype data to infer population structure and assign individuals to populations, which can be applied to most of the commonly used genetic markers, provided that they are not closely linked.
Journal ArticleDOI
Inference of Population Structure Using Multilocus Genotype Data: Linked Loci and Correlated Allele Frequencies
TL;DR: Extensions to the method of Pritchard et al. for inferring population structure from multilocus genotype data are described and methods that allow for linkage between loci are developed, which allows identification of subtle population subdivisions that were not detectable using the existing method.
Journal ArticleDOI
A Human Genome Diversity Cell Line Panel
Howard M. Cann,Claudia de Toma,Lucien Cazes,Marie Fernande Legrand,Valérie Morel,Laurence Piouffre,J. G. Bodmer,Walter F. Bodmer,Batsheva Bonne-Tamir,Anne Cambon-Thomsen,Zhu Chen,Jiayou Chu,Carlo Carcassi,Licinio Contu,Ruofu Du,Laurent Excoffier,G. B. Ferrara,Jonathan S. Friedlaender,Helena Groot,David Gurwitz,Trefor Jenkins,Rene J. Herrera,Xiaoyi Huang,Judith R. Kidd,Kenneth K. Kidd,André Langaney,Alice A. Lin,S. Qasim Mehdi,Peter Parham,Alberto Piazza,Maria Pia Pistillo,Yaping Qian,Qunfang Shu,Jiujin Xu,Shi-Yao Zhu,James L. Weber,Henry T. Greely,Marcus W. Feldman,Gilles Thomas,Jean Dausset,Luigi Luca Cavalli-Sforza +40 more
TL;DR: A resource of 1064 cultured lymphoblastoid cell lines from individuals in different world populations and corresponding milligram quantities of DNA is deposited at the Foundation Jean Dausset (CEPH) in Paris.
Journal ArticleDOI
Estimating African American admixture proportions by use of population-specific alleles.
Esteban J. Parra,Amy Marcini,Joshua M. Akey,Jeremy J. Martinson,Mark A. Batzer,Richard S. Cooper,Terrence Forrester,David B. Allison,Ranjan Deka,Robert E. Ferrell,Mark D. Shriver +10 more
TL;DR: Significant nonrandom association between two markers located 22 cM apart (FY-null and AT3) is detected, most likely due to admixture linkage disequilibrium created in the interbreeding of the two parental populations, emphasize the importance of admixed populations as a useful resource for mapping traits with different prevalence in two parental population.
Related Papers (5)
Genetic Variation and Population Structure in Native Americans
Sijia Wang,Cecil M. Lewis,Mattias Jakobsson,Sohini Ramachandran,Nicolas Ray,Gabriel Bedoya,Winston Rojas,María Victoria Parra,Julio Molina,Carla Gallo,Guido Mazzotti,Giovanni Poletti,Kim Hill,A. M. Hurtado,Damian Labuda,William Klitz,Ramiro Barrantes,Maria Cátira Bortolini,Francisco M. Salzano,Maria Luiza Petzl-Erler,Luiza T. Tsuneto,Elena Llop,Francisco Rothhammer,Francisco Rothhammer,Laurent Excoffier,Marcus W. Feldman,Noah A. Rosenberg,Andres Ruiz-Linares +27 more