Global increase and geographic convergence in antibiotic consumption between 2000 and 2015.
Eili Y. Klein,Eili Y. Klein,Thomas P. Van Boeckel,Elena Martinez,Suraj Pant,Sumanth Gandra,Simon A. Levin,Herman Goossens,Ramanan Laxminarayan,Ramanan Laxminarayan,Ramanan Laxminarayan +10 more
TLDR
It is found that the antibiotic consumption rate in low- and middle- income countries (LMICs) has been converging to (and in some countries surpassing) levels typically observed in high-income countries, and projected total global antibiotic consumption through 2030 was up to 200% higher than the 42 billion DDDs estimated in 2015.Abstract:
Tracking antibiotic consumption patterns over time and across countries could inform policies to optimize antibiotic prescribing and minimize antibiotic resistance, such as setting and enforcing per capita consumption targets or aiding investments in alternatives to antibiotics. In this study, we analyzed the trends and drivers of antibiotic consumption from 2000 to 2015 in 76 countries and projected total global antibiotic consumption through 2030. Between 2000 and 2015, antibiotic consumption, expressed in defined daily doses (DDD), increased 65% (21.1–34.8 billion DDDs), and the antibiotic consumption rate increased 39% (11.3–15.7 DDDs per 1,000 inhabitants per day). The increase was driven by low- and middle-income countries (LMICs), where rising consumption was correlated with gross domestic product per capita (GDPPC) growth (P = 0.004). In high-income countries (HICs), although overall consumption increased modestly, DDDs per 1,000 inhabitants per day fell 4%, and there was no correlation with GDPPC. Of particular concern was the rapid increase in the use of last-resort compounds, both in HICs and LMICs, such as glycylcyclines, oxazolidinones, carbapenems, and polymyxins. Projections of global antibiotic consumption in 2030, assuming no policy changes, were up to 200% higher than the 42 billion DDDs estimated in 2015. Although antibiotic consumption rates in most LMICs remain lower than in HICs despite higher bacterial disease burden, consumption in LMICs is rapidly converging to rates similar to HICs. Reducing global consumption is critical for reducing the threat of antibiotic resistance, but reduction efforts must balance access limitations in LMICs and take account of local and global resistance patterns.read more
Citations
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Microbial community response to ciprofloxacin toxicity in sponge membrane bioreactor.
Bao-Trong Dang,Xuan-Thanh Bui,Xuan-Thanh Bui,Tomoaki Itayama,Huu Hao Ngo,Deokjin Jahng,Chitsan Lin,Shiao-Shing Chen,Kun-Yi Andrew Lin,Thanh-Tin Nguyen,Dinh Duc Nguyen,Todd Saunders +11 more
TL;DR: It is found that the CIP toxicity decreased richness critical phylotypes such as phylum class ẟ-, β-, ɣ-proteobacteria, and Flavobacteria that co-respond to suppress denitrification and cake fouling to 37% and 28% respectively.
Journal ArticleDOI
Paving the Way for the Implementation of a Decision Support System for Antibiotic Prescribing in Primary Care in West Africa: Preimplementation and Co-Design Workshop With Physicians.
Nathan Peiffer-Smadja,Armel Poda,Abdoul-Salam Ouédraogo,J.-B. Guiard-Schmid,Tristan Delory,Tristan Delory,Josselin Le Bel,Elisabeth Bouvet,Sylvie Lariven,P. Jeanmougin,Raheelah Ahmad,Raheelah Ahmad,François-Xavier Lescure +12 more
TL;DR: The requirements for a CDSS adapted to the context of primary care in West Africa are examined, to analyze the barriers and facilitators of its implementation and adaptation, and to ensure co-designed solutions for its adaptation and sustainable use.
Journal ArticleDOI
Fate of antibiotics in engineered wastewater systems and receiving water environment: A case study on the coast of Hangzhou Bay, China.
TL;DR: In this paper, the fate of 77 antibiotics from 6 categories in two-step wastewater treatment plants (WTPs, i.e., pharmaceutical WTP and integrated WTP) was focused; and the antibiotics in both dissolved and adsorbed phases were investigated simultaneously.
Journal ArticleDOI
A decade of antimicrobial resistance research in social science fields: a scientometric review.
TL;DR: Social science research on AMR is a new, while rapidly developing, research area that requires continued and intense global efforts from an interdisciplinary and one health approach.
Journal ArticleDOI
Global sales of oral antibiotics formulated for children.
TL;DR: In this article, the authors investigate international consumption patterns of child-appropriate oral formulations of antibiotics by formulation type, with a focus on dispersible tablets, using data from a global sales database.
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