Global increase and geographic convergence in antibiotic consumption between 2000 and 2015.
Eili Y. Klein,Eili Y. Klein,Thomas P. Van Boeckel,Elena Martinez,Suraj Pant,Sumanth Gandra,Simon A. Levin,Herman Goossens,Ramanan Laxminarayan,Ramanan Laxminarayan,Ramanan Laxminarayan +10 more
TLDR
It is found that the antibiotic consumption rate in low- and middle- income countries (LMICs) has been converging to (and in some countries surpassing) levels typically observed in high-income countries, and projected total global antibiotic consumption through 2030 was up to 200% higher than the 42 billion DDDs estimated in 2015.Abstract:
Tracking antibiotic consumption patterns over time and across countries could inform policies to optimize antibiotic prescribing and minimize antibiotic resistance, such as setting and enforcing per capita consumption targets or aiding investments in alternatives to antibiotics. In this study, we analyzed the trends and drivers of antibiotic consumption from 2000 to 2015 in 76 countries and projected total global antibiotic consumption through 2030. Between 2000 and 2015, antibiotic consumption, expressed in defined daily doses (DDD), increased 65% (21.1–34.8 billion DDDs), and the antibiotic consumption rate increased 39% (11.3–15.7 DDDs per 1,000 inhabitants per day). The increase was driven by low- and middle-income countries (LMICs), where rising consumption was correlated with gross domestic product per capita (GDPPC) growth (P = 0.004). In high-income countries (HICs), although overall consumption increased modestly, DDDs per 1,000 inhabitants per day fell 4%, and there was no correlation with GDPPC. Of particular concern was the rapid increase in the use of last-resort compounds, both in HICs and LMICs, such as glycylcyclines, oxazolidinones, carbapenems, and polymyxins. Projections of global antibiotic consumption in 2030, assuming no policy changes, were up to 200% higher than the 42 billion DDDs estimated in 2015. Although antibiotic consumption rates in most LMICs remain lower than in HICs despite higher bacterial disease burden, consumption in LMICs is rapidly converging to rates similar to HICs. Reducing global consumption is critical for reducing the threat of antibiotic resistance, but reduction efforts must balance access limitations in LMICs and take account of local and global resistance patterns.read more
Citations
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TL;DR: Wang et al. as mentioned in this paper investigated the spatiotemporal distributions, risks, and prioritization of 15 widely used antibiotics in Laizhou Bay (LZB) and its estuaries and analyzed.
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Hospitalisations with infections related to antimicrobial-resistant bacteria from the French nationwide hospital discharge database, 2016.
M. Opatowski,Philippe Tuppin,K. Cosker,Mehdi Touat,G. De Lagasnerie,Didier Guillemot,Joshua A. Salomon,C. Brun-Buisson,Laurence Watier +8 more
TL;DR: Assessment of the overall annual incident number of hospitalised patients with AMR infection in France using the National Hospital Discharge database finds information from PMSI is comprehensive, covering all acute bacterial infections and a wide variety of microorganisms.
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Prolonged empirical antibiotic therapy is correlated with bloodstream infections and increased mortality in a tertiary care hospital in Ethiopia: bacteriology testing matters.
Makeda Semret,Workeabeba Abebe,Ling Yuan Kong,Tinsae Alemayehu,Temesgen Beyene,Michael Libman,Wondwossen Amogne,Øystein Haarklau Johannsen,Gebremedhin Beedemariam Gebretekle,Daniel Seifu,Cedric P. Yansouni +10 more
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