Journal ArticleDOI
Hepatoprotective effect of amoora rohituka
M. K. Gole,S. Dasgupta,R. K. Sur,J. Ghosal +3 more
- Vol. 35, Iss: 5, pp 318-322
TLDR
Antihepatotoxic activity of a resuspended residue of the alcohol extract of Amoora rohituka W & A. ro hituka W was studied in rats with hepatic injury induced by carbon tetrachloride and changes in the histological architecture of the liver produced by CC14 where also protected by the administration of A.rohituka suspension.Abstract:
Antihepatotoxic activity of a resuspended residue of the alcohol extract of Amoora rohituka W & A. (Meliaceae) was studied in rats with hepatic injury induced by carbon tetrachloride. Carbon tetrachloride (1 ml/kg, i.p.) was administered twice a week for 3 weeks and an extract of A. rohituka (50 mg/kg/day) was given orally for the same period. The rats were sacrificed 24 h after the last CC14 challenge. Carbon tetrachloride induced elevations of alkaline phosphatase (ALP), glutamate pyruvate transaminase (CPT), alanine aminotransferase (ALAT), glutamate oxaloacetate transaminase (GOT), aspartate aminotransferase (ASAT) and lactate dehydrogenase (LDH) and total plasma bilirubin concentration as well as depression of total plasma cholesterol concentration were reduced significantly by the concurrent treatment of rats with A. rohituka suspension. Changes in the histological architecture of the liver produced by CC14 where also protected by the administration of A. rohituka suspension. These results i...read more
Citations
More filters
Journal ArticleDOI
Optimization of the dose and route of injection, and characterisation of the time course of carbon tetrachloride-induced hepatotoxicity in the rat.
Sana Janakat,Hela Al-Merie +1 more
TL;DR: The optimum intraperitoneal dose of CCl(4) was found to be 2 ml/kg body weight (dissolved in an equal volume of olive oil), and this increased the level of bilirubin and the activity of the three enzymes significantly, without causing death of the animals.
Journal ArticleDOI
Lead finding from medicinal plants with hepatoprotective potentials.
TL;DR: An attempt has been made through this article to review the most potential medicinal plants with pharmacologically established hepatoprotective activity and finds the effective leads from natural resources for the desired therapeutic benefit.
Journal Article
Free Radical Scavenging (DPPH) and Ferric Reducing Ability (FRAP) of Aphanamixis polystachya (Wall) Parker
TL;DR: Aphanamixis polystachya (bark) was used as a potential preventive action taken to improve free radical-mediated diseases as discussed by the authors, which is used for the treatment of rheumatism, tumours, liver and spleen diseases.
PHARMACOGNOSTIC, PHYTOCHEMICAL AND ANTIMICROBIAL SCREENING OF APHANAMIXIS POLYSTACHYA, AN ENDANGERED MEDICINAL TREE Research Article
TL;DR: The zone of inhibitions indicates that the extracts of dried stem bark of Aphanamixis polystachya showed significant antimicrobial activity as comparison to kanamycin.
Journal ArticleDOI
The genus Amoora: A phytochemical and pharmacological review.
TL;DR: The present review may provide useful evidence for reasonable utilization of Amoora species as folk medicines and further research in drug discovery.
References
More filters
TheDistributions ofsome Granule-Associated EnzymesinGuinea-Pig Polymorphonuclear Leucocytes
TL;DR: It is concluded that the ;granule' fraction of the polymorphonuclear leucocyte, as isolated by previous workers, contains at least three, probably more, populations of particles with different enzyme contents, and that these cells probably do not contain peroxisomes.
Journal ArticleDOI
Hepatoprotective activity of polyphenolic compounds from Cynara scolymus against CCl4 toxicity in isolated rat hepatocytes.
TL;DR: The hepatoprotective activity against CCl4 toxicity in isolated rat hepatocytes of some polyphenolic compounds, such as cynarin, isochlorogenic Acid, chlorogenic acid, luteolin-7-glucoside, and two organic acids, caffeic and quinic, from Cynara scolymus, is tested.
Journal ArticleDOI
Studies on the activities of tannins and related compounds from medicinal plants and drugs. IV. Effects of various extracts of Geranii herba and geraniin on liver injury and lipid metabolism in rats fed peroxidized oil.
TL;DR: The effects of several kinds of extracts from the herb Geranium thunbergii and of geraniin, the main components of tannin of this herb, on liver injury produced in rats by feeding peroxidized oil were investigated and found to reduce lipid peroxide concentrations in the serum and liver of the animals with liver injury.
Journal ArticleDOI
Hepatoprotective effects of Andrographis paniculata against carbon tetrachloride-induced liver damage.
A. C. Rana,Y. Avadhoot +1 more
TL;DR: The extract of the leaves of Andrographis paniculata Ness was found to be effective in preventing liver damage which was evident by morphological, biochemical and functional parameters.
OtherDOI
Lipid Peroxidation: A Specific form of Cellular Injury
TL;DR: This article describes possible Mechanisms in Lipoperoxidative Cell Injury and Protective Mechanisms from Carbon Tetrachloride and concludes that Lipid Peroxidation-related cell injury is a major cause of apoptotic cell death.