IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans
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This article is published in Journal of Clinical Pathology.The article was published on 1980-01-01 and is currently open access. It has received 3514 citations till now.read more
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Toxicological approaches to complex mixtures.
TL;DR: The role of toxicological studies in understanding the health effects of environmental exposures to mixtures and the approach taken is to review mixtures that have received the grea...
Journal ArticleDOI
Mortality study of workers in 1,3-butadiene production units identified from a chemical workers cohort.
Elizabeth M. Ward,John M. Fajen,Avima M. Ruder,Robert A. Rinsky,William E. Halperin,Cindy A. Fessler-Flesch +5 more
TL;DR: A cohort mortality study among 364 men who were assigned to any of three 1,3-butadiene production units located within several chemical plants in the Kanawha Valley of West Virginia found a significantly elevated standardized mortality ratio (SMR) for lymphosarcoma and reticulosArcoma based on four observed cases.
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Toxicokinetics of Polar Chemicals in Zebrafish Embryo (Danio rerio): Influence of Physicochemical Properties and of Biological Processes
TL;DR: It is outlined that the uptake of polar compounds into ZFE is influenced by their physicochemical properties, but biological processes, biotransformation and, likely, efflux can strongly affect the internal concentrations already in early developmental stages of the ZFE.
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Risk factors of thyroid tumors: Role of environmental and occupational exposures to chemical pollutants
C. Leux,Pascal Guénel +1 more
TL;DR: Environmentalally abundant chemicals may disrupt thyroid function and/or play a role in tumorigenesis through a variety of mechanisms, and epidemiological results provide insufficient evidence of a causal link between exposure to environmental chemicals and thyroid tumors, but raise the hypothesis of an increased risk of thyroid neoplasm for workers in the leather, wood, and paper industries, and those exposed to certain solvents and pesticides.
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Exposure-response relationship between lung cancer and polycyclic aromatic hydrocarbons (PAHs).
Ben Armstrong,Graham W. Gibbs +1 more
TL;DR: The shape of the exposure–response function and the mode of combination of risks due to occupational PAH and smoking remains uncertain, but the estimated slope is broadly in line with the estimate from a previous follow-up of the same cohort, and somewhat higher than the average found in a recent meta-analysis of lung cancer studies.