IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans
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This article is published in Journal of Clinical Pathology.The article was published on 1980-01-01 and is currently open access. It has received 3514 citations till now.read more
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Journal ArticleDOI
Apoptosis and Growth Inhibition in Malignant Lymphocytes After Treatment With Arsenic Trioxide at Clinically Achievable Concentrations
Xin-Hua Zhu,Y. Shen,Yongkui Jing,Xun Cai,Pei-Ming Jia,Ying Huang,Wei Tang,Gui-Ying Shi,Yueping Sun,Jie Dai,Zhen-Yi Wang,Sai-Juan Chen,Ting-Dong Zhang,Samuel Waxman,Zhu Chen,Guo-Qiang Chen +15 more
TL;DR: Substantial growth inhibition and apoptosis without evidence of differentiation were induced in most malignant lymphocytic cells treated with 1-2 μM As 2 O 3, which may prove useful in the treatment ofmalignant lymphoproliferative disorders.
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Occupational exposures to polycyclic aromatic hydrocarbons, and respiratory and urinary tract cancers: a quantitative review to 2005
TL;DR: Increased risks from lung and bladder cancers were found in PAH-related occupations, apart from those for coal gasification, and whether they were due at least partially to some bias or confounding remains open to discussion.
Journal ArticleDOI
Contribution of environmental factors to cancer risk
Paolo Boffetta,Fredrik Nyberg +1 more
TL;DR: Despite the relatively small relative risks of cancer following exposure to environmental carcinogens, the number of cases that might be caused, assuming a causal relationship, is relatively large, as a result of the high prevalence of exposure.
Journal ArticleDOI
Predictors of pancreatic cancer mortality among a large cohort of United States adults.
TL;DR: It is confirmed that cigarette smoking is an important predictor of pancreatic cancer mortality, and several other factors that may contribute to increased risk are identified.
Journal ArticleDOI
TP53 and KRAS mutation load and types in lung cancers in relation to tobacco smoke : distinct patterns in never, former, and current smokers
Florence Le Calvez,Anush Mukeria,Jay D. Hunt,Olaf Kelm,Rayjean J. Hung,Philippe Tanière,Paul Brennan,Paolo Boffetta,David Zaridze,Pierre Hainaut +9 more
TL;DR: The notion that lung tumorigenesis proceeds through different molecular mechanisms according to smoking status is supported, as accumulation of N-Tyr suggests an etiology involving severe inflammation in never smokers.