IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans
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This article is published in Journal of Clinical Pathology.The article was published on 1980-01-01 and is currently open access. It has received 3514 citations till now.read more
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Malignant conversion of mouse skin tumours is increased by tumour initiators and unaffected by tumour promoters.
TL;DR: It is reported here that the tumour promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) is ineffective in the conversion of papillomas to carcinomas whereas three initiators, urethane, MNNG and 4-nitroquinoline-N-oxide (4-NQO) are effective, which suggests that malignant conversion may result from a further genetic change in papilloma cells and that the in
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Effect of smoking habit on the frequency of micronuclei in human lymphocytes: results from the human micronucleus project
Stefano Bonassi,Monica Neri,Cecilia Lando,Marcello Ceppi,Yi-ping Lin,Wushou P. Chang,Nina Holland,Micheline Kirsch-Volders,Errol Zeiger,Michael Fenech +9 more
TL;DR: It is confirmed that smokers do not experience an overall increase in MN frequency, although when the interaction with occupational exposure is taken into account, heavy smokers were the only group showing a significant increase in genotoxic damage as measured by the micronucleus assay in lymphocytes.
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Ranking animal carcinogens: a proposed regulatory approach
TL;DR: Different classes of animal carcinogens could be recognized and would permit several regulatory options and provide a means to establish priorities for public and scientific concerns.
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Chemical-activated luciferase gene expression (CALUX): a novel in vitro bioassay for Ah receptor active compounds in sediments and pore water.
Albertinka J. Murk,Juliette Legler,Michael S. Denison,John P. Giesy,C. Van De Guchte,A. Brouwer +5 more
TL;DR: This study demonstrates that the novelin vitroCALUX (chemical-activated luciferase expression) assay is a rapid, sensitive assay for assessing the toxic potency of (mixtures of) aryl hydrocarbon receptor (AhR)-active compounds in sediments and pore waters.
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Incidence of second primary tumours among childhood cancer survivors.
TL;DR: Radiotherapy appears to have been involved in the development of many of the SPTs observed following all FPTs excluding retinoblastoma, particularly after CNS tumours, Wilms' tumour and Hodgkin's disease.