IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans
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This article is published in Journal of Clinical Pathology.The article was published on 1980-01-01 and is currently open access. It has received 3514 citations till now.read more
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A prospective study of genetic polymorphism in MPO, antioxidant status, and breast cancer risk
Chunyan He,Rulla M. Tamimi,Rulla M. Tamimi,Susan E. Hankinson,Susan E. Hankinson,David J. Hunter,David J. Hunter,Jiali Han +7 more
TL;DR: Results from this study suggest that exogenous and endogenous modulators of oxidative stress may modify the association between the MPO polymorphism and breast cancer risk.
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Lymphoma, myeloma and occupation: Results of a case-control study
Lin Fritschi,Jack Siemiatycki +1 more
TL;DR: Examination of occupational exposures for lymphoma and myeloma in a large case‐control study examines in more detail those exposures previously considered to be related to these cancers, as well as exposures which were strongly related in initial analyses.
Journal Article
Modification of N-methyl-N'-nitro-N-nitrosoguanidine-induced forestomach and glandular stomach carcinogenesis by phenolic antioxidants in rats.
TL;DR: It was shown that CC, which is widely present in the authors' environment, is an unequivocal glandular stomach carcinogen also possessing strong enhancing activity for MNNG-induced lesion development and others displaying the same or greater potential for generating a hyperplastic response, like 4MP can exert an inhibitory effect.
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Polymorphism of metabolizing genes and lung cancer histology: Prevalence of CYP2E1 in adenocarcinoma
Randa El-Zein,Joseph B. Zwischenberger,Sherif Z. Abdel-Rahman,Aravind B. Sankar,William W. Au +4 more
TL;DR: The results of this study indicate that the inheritance of several polymorphic metabolizing genes, particularly the CYP2E1 gene, contributes not only to the development of lung cancer but also to theDevelopment of specific types of cancer.
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Global and MGMT promoter hypomethylation independently associated with genomic instability of lymphocytes in subjects exposed to high-dose polycyclic aromatic hydrocarbon
Huawei Duan,Zhini He,Junxiang Ma,Bo Zhang,Zhi-Guo Sheng,Ping Bin,Juan Cheng,Yong Niu,Haiyan Dong,Han Lin,Yufei Dai,Ben-Zhan Zhu,Wen Chen,Yongmei Xiao,Yuxin Zheng +14 more
TL;DR: In vitro study revealed that treatment of COE in 16HBE cells resulted in higher production of BPDE-DNA adducts, LINE-1 hypomethylation, hypomet H2O levels, and suppression of MGMT expression, suggesting hypometHylation of Line-1 and MGMT promoter could be used as markers for PAHs exposure and merit further investigation.