IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans
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This article is published in Journal of Clinical Pathology.The article was published on 1980-01-01 and is currently open access. It has received 3514 citations till now.read more
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Journal ArticleDOI
Cellular and molecular mechanisms of multistep carcinogenesis: relevance to carcinogen risk assessment.
J C Barrett,R W Wiseman +1 more
TL;DR: Carcinogenesis is a multistep process involving alterations in at least two distinct classes of genes, protooncogenes and tumor suppressor genes, which appear to act as positive proliferative signals for neoplastic growth.
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Biomarkers measured by cytokinesis-block micronucleus cytome assay for evaluating genetic damages induced by polycyclic aromatic hydrocarbons.
Huawei Duan,Shuguang Leng,Zufei Pan,Yufei Dai,Yong Niu,Chuanfeng Huang,Ping Bin,Yadong Wang,Qingjun Liu,Wen Chen,Yuxin Zheng +10 more
TL;DR: NPBs and NBUDs are more sensitive and reliable biomarkers for genetic damages induced by PAHs and could potentially be used for the biomonitoring of genotoxin-exposed populations.
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Assessment of Interactions between PAH Exposure and Genetic Polymorphisms on PAH-DNA Adducts in African American, Dominican, and Caucasian Mothers and Newborns
Shuang Wang,Stephen J. Chanock,Deliang Tang,Zhigang Li,Wieslaw Jedrychowski,Frederica P. Perera +5 more
TL;DR: Interactions between certain genetic polymorphisms and CYP1A1 haplotype and PAHs in mothers and their newborns in the three ethnic groups are suggestive only, warranting further study.
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Association of smoking with lower urinary tract symptoms.
TL;DR: The similarity in the odds ratios of lower urinary tract symptoms between current and former smokers suggests that changes caused by smoking occur long term or the pathological process resulting in symptoms starts early in smokers.
Journal ArticleDOI
A/J mouse as a model for lung tumorigenesis caused by tobacco smoke: strengths and weaknesses.
TL;DR: Strain A/J mice have successfully been used to develop an animal model for tobacco smoke carcinogenesis, and the assay allowed one to detect substantial chemopreventive activity of a mixture of myo-inositol and dexamethasone, but was less successful in showing efficacy for several other agents.