IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans
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This article is published in Journal of Clinical Pathology.The article was published on 1980-01-01 and is currently open access. It has received 3514 citations till now.read more
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Indirect mechanism of lead-induced genotoxicity in cultured mammalian cells
TL;DR: At all endpoints tested, lead ions interfere with the processing of UV-induced DNA damage, indicating an inhibition of DNA repair, and point out the necessity to consider such indirect effects when assessing the genotoxicity of metal compounds.
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Effect of ethanol on the tumorigenicity of urethane (ethyl carbamate) in B6C3F1 mice
Frederick A. Beland,R. Wayne Benson,Paul W. Mellick,Robert M. Kovatch,Dean W. Roberts,Jia-Long Fang,Daniel R. Doerge +6 more
TL;DR: Ethanol induced a dose-dependent trend in hepatocellular adenoma or carcinoma in male mice, with the incidence being marginally increased at the highest dose, and in female mice administered 10 ppm and 90 ppm urethane, ethanol caused dose-related increases in alveolar/bronchiolar adenomas or carcinomas and hemangiosarcoma of the heart, respectively.
Journal Article
Methylation of cytochrome P4501A1 promoter in the lung is associated with tobacco smoking.
Sisko Anttila,Jukka Hakkola,Päivi Tuominen,Eivor Elovaara,Kirsti Husgafvel-Pursiainen,Antti Karjalainen,Ari Hirvonen,Tuula Nurminen +7 more
TL;DR: The association of tobacco smoking with CYP1A1 methylation in the lung suggests that promoter methylation is involved in the regulation of CYP 1A1 induction in vivo.
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Accumulation and distribution of polycyclic aromatic hydrocarbons in rice (Oryza sativa).
TL;DR: Over the ripening period, PAH concentrations were increased in rice roots and decreased in most above-ground tissues, and there was a significant correlation between bioconcentration factor (BCF, plant over air) and octanol/air partitioning coefficient (Koa).
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Nature and nurture: possibilities for cancer control.
TL;DR: Attention is drawn to eight types of cancer that have become more common in the UK in the last 25 years, some of which the authors do not know how to prevent and which require urgent research.