Multi-allelic haplotype association identifies novel information different from single-SNP analysis: a new protective haplotype in the LRP8 gene is against familial and early-onset CAD and MI.
Gong Qing Shen,Domenico Girelli,Lin Li,Lin Li,Oliviero Olivieri,Nicola Martinelli,Qiuyun Chen,Qiuyun Chen,Eric J. Topol,Eric J. Topol,Qing Kenneth Wang +10 more
TLDR
This study analyzed four additional SNPs near R952Q to identify a specific LRP8 SNP haplotype that is associated with familial and early-onset coronary artery disease (CAD) and myocardial infarction (MI) in American and Italian Caucasian populations to suggest that a common L RP8 haplotype TCCGC confers a significant protective effect on the development of familial, early-ONSet CAD and/or MI.About:
This article is published in Gene.The article was published on 2013-05-25 and is currently open access. It has received 16 citations till now. The article focuses on the topics: Population & Platelet activation.read more
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Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders
Marcel den Hoed,Mark Eijgelsheim,Tõnu Esko,Bianca J. J. M. Brundel,David S. Peal,David M. Evans,Ilja M. Nolte,Ayellet V. Segrè,Hilma Holm,Robert E. Handsaker,Harm-Jan Westra,Toby Johnson,Aaron Isaacs,Jian Yang,Alicia Lundby,Jing Hua Zhao,Young Jin Kim,Min Jin Go,Peter Almgren,Murielle Bochud,Gabrielle Boucher,Marilyn C. Cornalis,Daniel F. Gudbjartsson,David Hadley,Pim van der Harst,Caroline Hayward,Martin den Heijer,Wilmar Igl,Anne U. Jackson,Zoltán Kutalik,Jian'an Luan,John P. Kemp,Kati Kristiansson,Claes Ladenvall,Mattias Lorentzon,May E. Montasser,Omer T. Njajou,Paul F. O'Reilly,Sandosh Padmanabhan,Beate St Pourcain,Tuomo Rankinen,Perttu Salo,Toshiko Tanaka,Nicholas J. Timpson,Veronique Vitart,Lindsay L. Waite,William Wheeler,Weihua Zhang,Harmen H.M. Draisma,Mary F. Feitosa,Kathleen F. Kerr,Penelope A. Lind,Evelin Mihailov,N. Charlotte Onland-Moret,Ci Song,Michael N. Weedon,Weijia Xie,Loic Yengo,Devin Absher,Christine M. Albert,Alvaro Alonso,Dan E. Arking,Paul I.W. de Bakker,Beverley Balkau,Cristina Barlassina,Paola Benaglio,Joshua C. Bis,Nabila Bouatia-Naji,Soren Brage,Stephen J. Chanock,Peter S. Chines,Mina K. Chung,Dawood Darbar,Christian Dina,Marcus Dörr,Paul Elliott,Stephan B. Felix,Krista Fischer,Christian Fuchsberger,Eco J. C. de Geus,Philippe Goyette,Vilmundur Gudnason,Tamara B. Harris,Anna-Liisa Hartikainen,Aki S. Havulinna,Susan R. Heckbert,Andrew A. Hicks,Albert Hofman,Suzanne Holewijn,Femke Hoogstra-Berends,Jouke-Jan Hottenga,Majken K. Jensen,Åsa Johansson,Juhani Junttila,Stefan Kääb,Bart Kanon,Shamika Ketkar,Kay-Tee Khaw,Joshua W. Knowles,Angad S. Kooner,Jan A. Kors,Meena Kumari,Lili Milani,Päivi Laiho,Edward G. Lakatta,Claudia Langenberg,Maarten Leusink,Yongmei Liu,Robert Luben,Kathryn L. Lunetta,Stacey N. Lynch,Marcello Ricardo Paulista Markus,Pedro Marques-Vidal,Irene Mateo Leach,Wendy L. McArdle,Steven A. McCarroll,Sarah E. Medland,Kathryn Miller,Grant W. Montgomery,Alanna C. Morrison,Martina Müller-Nurasyid,Pau Navarro,Mari Nelis,Jeffrey R. O'Connell,Christopher J. O'Donnell,Ken K. Ong,Anne B. Newman,Annette Peters,Ozren Polasek,Anneli Pouta,Peter P. Pramstaller,Bruce M. Psaty,Dabeeru C. Rao,Susan M. Ring,Elizabeth J. Rossin,Diana Rudan,Serena Sanna,Robert A. Scott,Jaban S. Sehmi,Stephen J. Sharp,Jordan T. Shin,Andrew B. Singleton,Albert V. Smith,Nicole Soranzo,Tim D. Spector,Chip Stewart,Heather M. Stringham,Kirill V. Tarasov,André G. Uitterlinden,Liesbeth Vandenput,Shih-Jen Hwang,John Whitfield,Cisca Wijmenga,Sarah H. Wild,Gonneke Willemsen,James F. Wilson,Jacqueline C. M. Witteman,Andrew Wong,Quenna Wong,Yalda Jamshidi,Paavo Zitting,Jolanda M. A. Boer,Dorret I. Boomsma,Ingrid B. Borecki,Cornelia M. van Duijn,Ulf Ekelund,Nita G. Forouhi,Philippe Froguel,Aroon D. Hingorani,Erik Ingelsson,Mika Kivimäki,Richard A. Kronmal,Diana Kuh,Lars Lind,Nicholas G. Martin,Ben A. Oostra,Nancy L. Pedersen,Thomas Quertermous,Jerome I. Rotter,Yvonne T. van der Schouw,W. M. Monique Verschuren,Mark Walker,Demetrius Albanes,David O. Arnar,Themistocles L. Assimes,Stefania Bandinelli,Michael Boehnke,Rudolf A. de Boer,Claude Bouchard,L Mark Caulfield W L Mark Caulfield,John C. Chambers,Gary C. Curhan,Daniele Cusi,Johan G. Eriksson,Luigi Ferrucci,Wiek H. van Gilst,Nicola Glorioso,Jacqueline de Graaf,Leif Groop,Ulf Gyllensten,Wen Chi Hsueh,Frank B. Hu,Heikki V. Huikuri,David J. Hunter,Carlos Iribarren,Bo Isomaa,Marjo-Riitta Järvelin,Antti Jula,Mika Kähönen,Lambertus A. Kiemeney,Melanie M. van der Klauw,Jaspal S. Kooner,Peter Kraft,Licia Iacoviello,Terho Lehtimäki,Marja-Liisa Lokki,Braxton D. Mitchell,Gerjan Navis,Markku S. Nieminen,Claes Ohlsson,Neil Poulter,Lu Qi,Olli T. Raitakari,Eric B. Rimm,John D. Rioux,Federica Rizzi,Igor Rudan,Veikko Salomaa,Peter S. Sever,Denis C. Shields,Alan R. Shuldiner,Juha Sinisalo,Alice Stanton,Ronald P. Stolk,David P. Strachan,Jean-Claude Tardif,Unnur Thorsteinsdottir,J. Tuomilehto,Dirk J. van Veldhuisen,Jarmo Virtamo,Jorma Viikari,Peter Vollenweider,Gérard Waeber,Elisabeth Widen,Yoon Shin Cho,Jesper V. Olsen,Peter M. Visscher,Cristen J. Willer,Lude Franke,Jeanette Erdmann,John R. Thompson,Arne Pfeufer,Nona Sotoodehnia,Christopher Newton-Cheh,Patrick T. Ellinor,Bruno H. Stricker,Andres Metspalu,Markus Perola,Jacques S. Beckmann,George Davey Smith,Kari Stefansson,Nicholas J. Wareham,Patricia B. Munroe,Ody C. M. Sibon,David J. Milan,Harold Snieder,Nilesh J. Samani,Ruth J. F. Loos +267 more
TL;DR: A 2-stage meta-analysis of genome-wide association studies in up to 181,171 individuals identified 14 new loci associated with heart rate and confirmed associations with all 7 previously established loci, providing fresh insights into the mechanisms regulating heart rate.
Journal ArticleDOI
Genetics of coronary artery disease and myocardial infarction.
TL;DR: The clinical heterogeneity of CAD and MI is described to clarify the disease spectrum in genetic studies, and multiple genetic factors associated with an increased risk of in-stent restenosis following stent placement for obstructive CAD are identified.
Journal ArticleDOI
Genetic variants of ApoE and ApoER2 differentially modulate endothelial function
Victoria Ulrich,Eddy S. Konaniah,Joachim Herz,Robert D. Gerard,Eunjeong Jung,Ivan S. Yuhanna,Mohamed M. Ahmed,David Y. Hui,Chieko Mineo,Philip W. Shaul +9 more
TL;DR: It is reported that in endothelial cells apoE3 binding to ApoER2 stimulates endothelial NO synthase (eNOS) and endothelial cell migration, and it also attenuates monocyte–endothelial cell adhesion, however, apOE4 does not stimulate eNOS or endothelium migration or dampen cellAdhesion, and alternatively it selectively antagonizes apo E3/ApoER2 actions.
Journal ArticleDOI
Apolipoprotein E receptor-2 deficiency enhances macrophage susceptibility to lipid accumulation and cell death to augment atherosclerotic plaque progression and necrosis.
TL;DR: This study indicates that apoER2 in macrophages limits PParγ expression and protects against oxLDL-induced cell death, and suggests that LRP8 polymorphism may be a genetic modifier of cardiovascular risk with PPARγ therapy.
Journal ArticleDOI
Interaction between prenatal pesticide exposure and a common polymorphism in the PON1 gene on DNA methylation in genes associated with cardio-metabolic disease risk—an exploratory study
Ken Declerck,Sylvie Remy,Christine Wohlfahrt-Veje,Katharina M. Main,Guy Van Camp,Greet Schoeters,Greet Schoeters,Wim Vanden Berghe,Helle Raun Andersen +8 more
TL;DR: Investigating whether DNA methylation patterns in blood cells were related to prenatal pesticide exposure level, PON1 Q192R genotype, and associated metabolic effects observed in the children found it necessary to identify possible candidate genes which mediated the associations between pesticide exposure and increased leptin level, body fat percentage, and difference in BMI Z score between birth and school age.
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The family history--more important than ever.
TL;DR: The authors make the case for taking a good family history in the era of genomic medicine and provide a computer tool that can be downloaded and used by patients to help record this history.
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Premature Myocardial Infarction Novel Susceptibility Locus on Chromosome 1P34-36 Identified by Genomewide Linkage Analysis
Qing Wang,Shaoqi Rao,Gong Qing Shen,Lin Li,David J. Moliterno,L. Kristin Newby,William J. Rogers,Ruth Cannata,Erich Zirzow,Robert C. Elston,Eric J. Topol +10 more
TL;DR: A novel genetic-susceptibility locus is identified for MI and a framework for the ultimate cloning of a gene for the complex disease MI is provided.
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