Journal ArticleDOI
Ontogeny and homeostasis of CNS myeloid cells.
TLDR
Studies using cell-specific targeting, in vivo imaging, single-cell expression analysis and other sophisticated tools have increased the depth of knowledge of this immune-cell compartment and call for reevaluation of the traditional views on the origin, fate and function of distinct CNS myeloid subsets.Abstract:
Myeloid cells in the central nervous system (CNS) represent a heterogeneous class of innate immune cells that contribute to the maintenance of tissue homeostasis differentially during development and adulthood. The subsets of CNS myeloid cells identified so far, including parenchymal microglia and non-parenchymal meningeal, perivascular and choroid-plexus macrophages, as well as disease-associated monocytes, have classically been distinguished on the basis of their surface epitope expression, localization and morphology. However, studies using cell-specific targeting, in vivo imaging, single-cell expression analysis and other sophisticated tools have now increased the depth of knowledge of this immune-cell compartment and call for reevaluation of the traditional views on the origin, fate and function of distinct CNS myeloid subsets. The concepts of CNS macrophage biology that are emerging from these new insights have broad implications for the understanding and treatment of CNS diseases.read more
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A lineage of myeloid cells independent of Myb and hematopoietic stem cells
Elisa Gomez Perdiguero,Christian Schulz,Laurent Chorro,Heather L. Szabo-Rogers,Nicolas Cagnard,Katrin Kierdorf,Marco Prinz,Bishan Wu,Jacobsen Sew.,Jeffrey W. Pollard,Jon Frampton,Karen J. Liu,Frederic Geissmann +12 more
TL;DR: Schulz et al. as discussed by the authors investigated whether adult macrophages all share a common developmental origin and found that a population of yolk-sac-derived, tissue-resident macophages was able to develop and persist in adult mice in the absence of hematopoietic stem cells.
Journal ArticleDOI
The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease
TL;DR: Evidence supports a conceptual shift in the mechanisms of neurovascular coupling, from a unidimensional process involving neuronal-astrocytic signaling to local blood vessels to a multidimensional one in which mediators released from multiple cells engage distinct signaling pathways and effector systems across the entire cerebrovascular network in a highly orchestrated manner.
Journal ArticleDOI
Microglia and macrophages in brain homeostasis and disease
Qingyun Li,Ben A. Barres +1 more
TL;DR: The current knowledge of how and where brain macrophages are generated is reviewed, with a focus on parenchymal microglia and their normal functions during development and homeostasis are discussed.
Journal ArticleDOI
Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution.
Takahiro Masuda,Roman Sankowski,Ori Staszewski,Chotima Böttcher,Lukas Amann,Sagar,Christian Scheiwe,Stefan Nessler,Patrik Kunz,Geert van Loo,Volker A. Coenen,Peter C. Reinacher,Anna Michel,Ulrich Sure,Ralf Gold,Dominic Grün,Josef Priller,Josef Priller,Christine Stadelmann,Marco Prinz +19 more
TL;DR: Insight is provided into the endogenous immune system of the central nervous system during development, homeostasis and disease, and may also provide new targets for the treatment of neurodegenerative and neuroinflammatory pathologies.
Journal ArticleDOI
Microglia Biology: One Century of Evolving Concepts.
TL;DR: Progress in imaging and genetics and the advent of single-cell technologies provided new insights into the much more complex and fascinating biology of microglia, and their functions in health and disease were better defined.
References
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Selective targeting of perivascular macrophages for clearance of β-amyloid in cerebral amyloid angiopathy
Cheryl A. Hawkes,JoAnne McLaurin +1 more
TL;DR: The role of perivascular macrophages in regulating CAA severity in the TgCRND8 mouse model of AD is investigated and it is suggested that selective targeting of perIV vascular macrophage activation might constitute a therapeutic strategy to clear vascular amyloid.
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TMEM119 marks a subset of microglia in the human brain
Jun-ichi Satoh,Yoshihiro Kino,Naohiro Asahina,Mika Takitani,Junko Miyoshi,Tsuyoshi Ishida,Yuko Saito +6 more
TL;DR: Results suggest that TMEM119 serves as a reliable microglial marker that discriminates resident microglia from blood‐derived macrophages in the human brain.
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Distinct and Non-Redundant Roles of Microglia and Myeloid Subsets in Mouse Models of Alzheimer's Disease
Alexander Mildner,Bernhard Schlevogt,Katrin Kierdorf,Chotima Böttcher,Daniel Erny,Markus P. Kummer,Michael Quinn,Wolfgang Brück,Ingo Bechmann,Michael T. Heneka,Josef Priller,Marco Prinz +11 more
TL;DR: Together, the data advocate selective functions of CCR2-expressing myeloid subsets, which could be targeted specifically to modify disease burden in AD.
Journal ArticleDOI
Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis
TL;DR: It is concluded that a CD8+ T- cell-dependent disorder can proceed in the absence of direct T-cell effector mechanisms and rely instead on CTL-recruited myelomonocytic cells.
Journal ArticleDOI
Expression of Ia antigen on perivascular and microglial cells after sublethal and lethal motor neuron injury.
TL;DR: The existence of a population of immunocompetent perivascular cells normally present in adult rat brain that can be stimulated to express Ia antigen and a subpopulation of ramified microglia that arises through transformation of Ia-positive periv vascular cells in the adult under pathological conditions are proposed.