Journal ArticleDOI
Ontogeny and homeostasis of CNS myeloid cells.
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TLDR
Studies using cell-specific targeting, in vivo imaging, single-cell expression analysis and other sophisticated tools have increased the depth of knowledge of this immune-cell compartment and call for reevaluation of the traditional views on the origin, fate and function of distinct CNS myeloid subsets.Abstract:
Myeloid cells in the central nervous system (CNS) represent a heterogeneous class of innate immune cells that contribute to the maintenance of tissue homeostasis differentially during development and adulthood. The subsets of CNS myeloid cells identified so far, including parenchymal microglia and non-parenchymal meningeal, perivascular and choroid-plexus macrophages, as well as disease-associated monocytes, have classically been distinguished on the basis of their surface epitope expression, localization and morphology. However, studies using cell-specific targeting, in vivo imaging, single-cell expression analysis and other sophisticated tools have now increased the depth of knowledge of this immune-cell compartment and call for reevaluation of the traditional views on the origin, fate and function of distinct CNS myeloid subsets. The concepts of CNS macrophage biology that are emerging from these new insights have broad implications for the understanding and treatment of CNS diseases.read more
Citations
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Journal ArticleDOI
Decoding the temporal and regional specification of microglia in the developing human brain.
Yanxin Li,Zhongqiu Li,Min Yang,Feiyang Wang,Yue Zhang,R. Li,Qian Li,Yunxia Gong,Binhong Wang,Baoguang Fan,Chunyue Wang,Lei Chen,Hong Li,Jennie Ong,Zhao Teng,Lei Jin,Yan-Ling Wang,Peng Du,Jianwei Jiao +18 more
TL;DR: In this paper , the authors profile single-cell transcriptomes of microglia from distinct regions of the developing human brain, and combined with experimental verification, define and characterize early microglial fate determinations related to regional specification and state transition.
Posted ContentDOI
Can quantifying morphology and TMEM119 expression distinguish between microglia and infiltrating macrophages after ischemic stroke and reperfusion in male and female mice
Kimberly Young,Rebeca Gardner,Victoria C. Sariana,Susan A. Whitman,Mitchell J. Barlett,Torsten Falk,Helena W. Morrison +6 more
TL;DR: It is suggested that TMEM119 is not a stable microglia marker in male and female mice in the context of ischemic stroke and its use to distinguish between cell populations following brain injury with cell infiltration is cautioned.
Journal ArticleDOI
Studying Heterotypic Cell–Cell Interactions in the Human Brain Using Pluripotent Stem Cell Models for Neurodegeneration
TL;DR: The cellular interactions and the physiological roles of neural cells with other cell types including endothelial cells and microglia based on iPSC models are discussed and Neuronal-microglia interactions mediated by chemokines signaling can be modulated in vitro for recapitulating microglial activities during neurodegenerative disease progression.
Journal ArticleDOI
More attention on glial cells to have better recovery after spinal cord injury.
Sajad Hassanzadeh,Maryam Jalessi,Seyed Behnamedin Jameie,Mehdi Khanmohammadi,Zohre Bagher,Zeinab Namjoo,Seyed Mohammad Davachi +6 more
TL;DR: In this paper, the authors examined recent findings on glial cell subtypes and their beneficial or detrimental effects after spinal cord injury and discussed how they may be able to help the functional recovery process after injury.
Journal ArticleDOI
ALK4/5-dependent TGF-β signaling contributes to the crosstalk between neurons and microglia following axonal lesion.
Antonella Raffo-Romero,Antonella Raffo-Romero,Tanina Arab,Tanina Arab,Christelle Van Camp,Christelle Van Camp,Quentin Lemaire,Quentin Lemaire,Maxence Wisztorski,Maxence Wisztorski,Julien Franck,Julien Franck,Soulaimane Aboulouard,Soulaimane Aboulouard,Francoise Le Marrec-Croq,Francoise Le Marrec-Croq,Pierre-Eric Sautiere,Pierre-Eric Sautiere,Jacopo Vizioli,Jacopo Vizioli,Michel Salzet,Michel Salzet,Christophe Lefebvre,Christophe Lefebvre +23 more
TL;DR: It is demonstrated that ALK4/5 signaling is essential throughout the response to the lesion in the leech CNS and is an important signal contributing to a correct sequential mobilization over time of microglia recruitment leading to axon regeneration.
References
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Journal ArticleDOI
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Florent Ginhoux,Florent Ginhoux,Melanie Greter,Marylene Leboeuf,Sayan Nandi,Peter See,Solen Gokhan,Mark F. Mehler,Simon J. Conway,Lai Guan Ng,E. Richard Stanley,Igor M. Samokhvalov,Miriam Merad +12 more
TL;DR: Results identify microglia as an ontogenically distinct population in the mononuclear phagocyte system and have implications for the use of embryonically derived microglial progenitors for the treatment of various brain disorders.
Journal ArticleDOI
Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq
Amit Zeisel,Ana B. Muñoz-Manchado,Simone Codeluppi,Peter Lönnerberg,Gioele La Manno,Anna Juréus,Sueli Marques,Hermany Munguba,Liqun He,Christer Betsholtz,Christer Betsholtz,Charlotte Rolny,Gonçalo Castelo-Branco,Jens Hjerling-Leffler,Sten Linnarsson +14 more
TL;DR: Large-scale single-cell RNA sequencing is used to classify cells in the mouse somatosensory cortex and hippocampal CA1 region and found 47 molecularly distinct subclasses, comprising all known major cell types in the cortex.
Journal ArticleDOI
Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
Simon Yona,Ki-Wook Kim,Yochai Wolf,Alexander Mildner,Diana Varol,Michal Breker,Dalit Strauss-Ayali,Sergey Viukov,Martin Guilliams,Alexander V. Misharin,David A. Hume,Harris Perlman,Bernard Malissen,Elazar Zelzer,Steffen Jung +14 more
TL;DR: A fate-mapping study of the murine monocyte and macrophage compartment taking advantage of constitutive and conditional CX(3)CR1 promoter-driven Cre recombinase expression is reported, establishing that short-lived Ly6C(+) monocytes constitute obligatory steady-state precursors of blood-resident Ly 6C(-) cells and that the abundance of Ly6 C(+) blood monocytes dynamically controls the circulation lifespan of their progeny.
Journal ArticleDOI
Host microbiota constantly control maturation and function of microglia in the CNS
Daniel Erny,Anna Lena Hrabě de Angelis,Diego Jaitin,Peter Wieghofer,Ori Staszewski,Eyal David,Hadas Keren-Shaul,Tanel Mahlakõiv,Kristin Jakobshagen,Thorsten Buch,Vera Schwierzeck,Olaf Utermöhlen,Eunyoung Chun,Wendy S. Garrett,Kathy D. McCoy,Andreas Diefenbach,Peter Staeheli,Bärbel Stecher,Ido Amit,Marco Prinz +19 more
TL;DR: It is determined that short-chain fatty acids (SCFA), microbiota-derived bacterial fermentation products, regulated microglia homeostasis and mice deficient for the SCFA receptor FFAR2 mirroredmicroglia defects found under GF conditions, suggesting that host bacteria vitally regulate microglian maturation and function.
Journal ArticleDOI
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
Christian Schulz,Elisa Gomez Perdiguero,Laurent Chorro,Heather L. Szabo-Rogers,Nicolas Cagnard,Katrin Kierdorf,Marco Prinz,Bishan Wu,Sten Eirik W. Jacobsen,Jeffrey W. Pollard,Jon Frampton,Karen J. Liu,Frederic Geissmann +12 more
TL;DR: It is found that the transcription factor Myb was required for development of HSCs and all CD11bhigh monocytes and macrophages, but was dispensable for yolk sac (YS)macrophages and for the development of YS-derived F4/80bright macrophage populations in several tissues.