Journal ArticleDOI
Ontogeny and homeostasis of CNS myeloid cells.
TLDR
Studies using cell-specific targeting, in vivo imaging, single-cell expression analysis and other sophisticated tools have increased the depth of knowledge of this immune-cell compartment and call for reevaluation of the traditional views on the origin, fate and function of distinct CNS myeloid subsets.Abstract:
Myeloid cells in the central nervous system (CNS) represent a heterogeneous class of innate immune cells that contribute to the maintenance of tissue homeostasis differentially during development and adulthood. The subsets of CNS myeloid cells identified so far, including parenchymal microglia and non-parenchymal meningeal, perivascular and choroid-plexus macrophages, as well as disease-associated monocytes, have classically been distinguished on the basis of their surface epitope expression, localization and morphology. However, studies using cell-specific targeting, in vivo imaging, single-cell expression analysis and other sophisticated tools have now increased the depth of knowledge of this immune-cell compartment and call for reevaluation of the traditional views on the origin, fate and function of distinct CNS myeloid subsets. The concepts of CNS macrophage biology that are emerging from these new insights have broad implications for the understanding and treatment of CNS diseases.read more
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A lineage of myeloid cells independent of Myb and hematopoietic stem cells
Elisa Gomez Perdiguero,Christian Schulz,Laurent Chorro,Heather L. Szabo-Rogers,Nicolas Cagnard,Katrin Kierdorf,Marco Prinz,Bishan Wu,Jacobsen Sew.,Jeffrey W. Pollard,Jon Frampton,Karen J. Liu,Frederic Geissmann +12 more
TL;DR: Schulz et al. as discussed by the authors investigated whether adult macrophages all share a common developmental origin and found that a population of yolk-sac-derived, tissue-resident macophages was able to develop and persist in adult mice in the absence of hematopoietic stem cells.
Journal ArticleDOI
The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease
TL;DR: Evidence supports a conceptual shift in the mechanisms of neurovascular coupling, from a unidimensional process involving neuronal-astrocytic signaling to local blood vessels to a multidimensional one in which mediators released from multiple cells engage distinct signaling pathways and effector systems across the entire cerebrovascular network in a highly orchestrated manner.
Journal ArticleDOI
Microglia and macrophages in brain homeostasis and disease
Qingyun Li,Ben A. Barres +1 more
TL;DR: The current knowledge of how and where brain macrophages are generated is reviewed, with a focus on parenchymal microglia and their normal functions during development and homeostasis are discussed.
Journal ArticleDOI
Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution.
Takahiro Masuda,Roman Sankowski,Ori Staszewski,Chotima Böttcher,Lukas Amann,Sagar,Christian Scheiwe,Stefan Nessler,Patrik Kunz,Geert van Loo,Volker A. Coenen,Peter C. Reinacher,Anna Michel,Ulrich Sure,Ralf Gold,Dominic Grün,Josef Priller,Josef Priller,Christine Stadelmann,Marco Prinz +19 more
TL;DR: Insight is provided into the endogenous immune system of the central nervous system during development, homeostasis and disease, and may also provide new targets for the treatment of neurodegenerative and neuroinflammatory pathologies.
Journal ArticleDOI
Microglia Biology: One Century of Evolving Concepts.
TL;DR: Progress in imaging and genetics and the advent of single-cell technologies provided new insights into the much more complex and fascinating biology of microglia, and their functions in health and disease were better defined.
References
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P2Y12 receptor is expressed on human microglia under physiological conditions throughout development and is sensitive to neuroinflammatory diseases.
TL;DR: The results suggest that P2Y12 is a useful marker for the identification of human microglia throughout the lifespan, and might help to discriminate activated microglial and infiltrating myeloid cells from quiescent microglian cells in the human CNS.
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Microglial cells are a component of the perivascular glia limitans.
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Journal ArticleDOI
Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain
Niroshana Anandasabapathy,Gabriel D. Victora,Gabriel D. Victora,Matthew M. Meredith,Rachel E. Feder,Baojun Dong,Courtney Kluger,Kai-Hui Yao,Michael L. Dustin,Michel C. Nussenzweig,Ralph M. Steinman,Kang Liu,Kang Liu +12 more
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Involvement of specific macrophage-lineage cells surrounding arterioles in barrier and scavenger function in brain cortex.
Masao Mato,Shigeo Ookawara,Atsushi Sakamoto,Eizo Aikawa,Tsuyoshi Ogawa,Umehachi Mitsuhashi,Toshio Masuzawa,Hiroshi Suzuki,Makoto Honda,Yoshio Yazaki,Eiju Watanabe,Jukka Luoma,Seppo Ylä-Herttuala,Iain D. C. Fraser,Siamon Gordon,Tatsuhiko Kodama +15 more
TL;DR: It is reported that specific cells surrounding arterioles, known as Mato's fluorescent granular perithelial (FGP) cells or perivascular microglial cells, contribute to the barrier function.