Journal ArticleDOI
Pathophysiologic mechanisms of acute ischemic stroke: An overview with emphasis on therapeutic significance beyond thrombolysis
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TLDR
The objective of this review is to critically evaluate the major mechanisms underlying stroke pathophysiology, with emphasis on potential novel targets for designing newer therapeutic modalities.About:
This article is published in Pathophysiology.The article was published on 2010-06-01. It has received 492 citations till now. The article focuses on the topics: Ischemic cascade & Stroke.read more
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Book ChapterDOI
Translational Neuroscience of Aphasia and Adult Language Rehabilitation
Dimitrios Kasselimis,Georgios Papageorgiou,Georgia Angelopoulou,Dimitrios Tsolakopoulos,Constantin Potagas +4 more
TL;DR: In this paper, the authors discuss the challenges that arise in research related to aphasia rehabilitation and recovery, as well as investigations of the language-related brain mechanisms, especially when attempting to integrate findings derived from basic neuroscience and studies with clinical populations.
Journal ArticleDOI
Phosphodiesterase-5 Inhibitor Attenuates Anxious Phenotypes and Movement Disorder Induced by Mild Ischemic Stroke in Rats
Yeon Hee Yu,Seong Wook Kim,Ju Hyeon Kang,Ye Na Song,Hyuna Im,Seo Jeong Kim,Dae Young Yoo,Man Ryul Lee,Dae-Kyoon Park,J. Oh,Duk-Soo Kim +10 more
TL;DR: PDE5i as effective therapeutic agents for anxiety and movement disorders and robust preclinical evidence to support the development and use of PDE5 i for the treatment of mild ischemic stroke residual disorders are provided.
Journal ArticleDOI
Protocol for the development of a core outcome set for evaluating mixed-diagnosis falls prevention interventions for people with Multiple Sclerosis, Parkinson's Disease and stroke.
TL;DR: In this article , the authors developed a core outcome set (COS) for evaluating mixed-diagnosis falls prevention interventions for people with MS, Parkinson's Disease (PD) and stroke.
Journal ArticleDOI
The Cardioprotective Effect of Corosolic Acid in the Diabetic Rats: A Possible Mechanism of the PPAR-γ Pathway
TL;DR: In this paper , a study was conducted to determine whether corosolic acid could protect the myocardium of diabetic rats from damage caused by isoproterenol (ISO) and, if so, how peroxisome proliferator-activated receptor gamma activation might contribute into this protection.
References
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Journal ArticleDOI
Atherosclerosis — An Inflammatory Disease
TL;DR: Atherosclerosis is an inflammatory disease as discussed by the authors, and it is a major cause of death in the United States, Europe, and much of Asia, despite changes in lifestyle and use of new pharmacologic approaches to lower plasma cholesterol concentrations.
Journal ArticleDOI
Direct Proinflammatory Effect of C-Reactive Protein on Human Endothelial Cells
TL;DR: The hypothesis that CRP may play a direct role in promoting the inflammatory component of atherosclerosis and present a potential target for the treatment of Atherosclerosis is supported.
Journal ArticleDOI
p53 Has a Direct Apoptogenic Role at the Mitochondria
Motohiro Mihara,Susan Erster,Alex Zaika,Oleksi Petrenko,Thomas Chittenden,Petr Pancoska,Ute M. Moll +6 more
TL;DR: Evidence that p53 translocation to the mitochondria occurs in vivo in irradiated thymocytes is provided and it is shown that the p53 protein can directly induce permeabilization of the outer mitochondrial membrane by forming complexes with the protective BclXL and Bcl2 proteins, resulting in cytochrome c release.
Journal ArticleDOI
Glutamate-mediated astrocyte-neuron signalling.
Vladimir Parpura,Trent A. Basarsky,Fang Liu,Ksenija Jeftinija,Srdija Jeftinija,Philip G. Haydon +5 more
TL;DR: Astrocytes regulate neuronal calcium levels through the calcium-dependent release of glutamate, and an NMDA (N-methyl-d-aspartate) receptor-mediated increase in neuronal calcium is demonstrated.
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