Journal ArticleDOI
Pathophysiologic mechanisms of acute ischemic stroke: An overview with emphasis on therapeutic significance beyond thrombolysis
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TLDR
The objective of this review is to critically evaluate the major mechanisms underlying stroke pathophysiology, with emphasis on potential novel targets for designing newer therapeutic modalities.About:
This article is published in Pathophysiology.The article was published on 2010-06-01. It has received 492 citations till now. The article focuses on the topics: Ischemic cascade & Stroke.read more
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Recent advances in the development of neuroprotective agents and therapeutic targets in the treatment of cerebral ischemia.
TL;DR: Current research and developments regarding small molecular compounds, including natural products and newly synthesized compounds that have neuroprotective effects and potential molecular targets for the recovery of post-ischemic stroke neural function that have been identified through lab investigations conducted during the last five years are reviewed.
Journal ArticleDOI
The influence of stroke risk factors and comorbidities on assessment of stroke therapies in humans and animals.
TL;DR: The impact of the risk factors most studied in animal models of acute stroke and the parallels with human stroke are highlighted and, where possible, their influence on evaluation of therapeutic strategies are highlighted.
Journal ArticleDOI
Blocking lncRNA H19-miR-19a-Id2 axis attenuates hypoxia/ischemia induced neuronal injury.
Zhipeng Xiao,Yongming Qiu,Yingying Lin,Rogelio Medina,Sophie Zhuang,Jared S. Rosenblum,Jing Cui,Zezhi Li,Xiaohua Zhang,Liemei Guo +9 more
TL;DR: It is demonstrated that the identified H19-miR-19a-Id2 axis plays a critical role in hypoxia induced neuronal apoptosis, and blocking this axis may serve as a novel therapeutic strategy for ischemic brain injury.
Journal Article
Activation of the calcium-sensing receptor promotes apoptosis by modulating the JNK/p38 MAPK pathway in focal cerebral ischemia-reperfusion in mice.
TL;DR: The CaSR activation promotes apoptosis in focal cerebral I/R in mice, which may be related to the activation of JNK/p38 MAPK signalling pathway, and targeting CaSR may be a novel strategy for the prevention and treatment of cerebral ischemic stroke.
Journal ArticleDOI
Protective cerebrovascular effects of hydroxysafflor yellow A (HSYA) on ischemic stroke.
Yang Sun,Dong-Ping Xu,Zhen Qin,Peng-Yuan Wang,Bo-Han Hu,Jian-Guang Yu,Yong Zhao,Ben Cai,Yong-Ling Chen,Min Lu,Jian-Guo Liu,Xia Liu +11 more
TL;DR: In vitro, HSYA had a strong effect on cerebrovascular vasodilatation, and significantly decreased platelet aggregation, blood viscosity, and thrombogenesis, and in vitro,HSYA protects against ischemic stroke by dilating cerebral vessels and improving cerebroVascular permeability.
References
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Journal ArticleDOI
Atherosclerosis — An Inflammatory Disease
TL;DR: Atherosclerosis is an inflammatory disease as discussed by the authors, and it is a major cause of death in the United States, Europe, and much of Asia, despite changes in lifestyle and use of new pharmacologic approaches to lower plasma cholesterol concentrations.
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Direct Proinflammatory Effect of C-Reactive Protein on Human Endothelial Cells
TL;DR: The hypothesis that CRP may play a direct role in promoting the inflammatory component of atherosclerosis and present a potential target for the treatment of Atherosclerosis is supported.
Journal ArticleDOI
p53 Has a Direct Apoptogenic Role at the Mitochondria
Motohiro Mihara,Susan Erster,Alex Zaika,Oleksi Petrenko,Thomas Chittenden,Petr Pancoska,Ute M. Moll +6 more
TL;DR: Evidence that p53 translocation to the mitochondria occurs in vivo in irradiated thymocytes is provided and it is shown that the p53 protein can directly induce permeabilization of the outer mitochondrial membrane by forming complexes with the protective BclXL and Bcl2 proteins, resulting in cytochrome c release.
Journal ArticleDOI
Glutamate-mediated astrocyte-neuron signalling.
Vladimir Parpura,Trent A. Basarsky,Fang Liu,Ksenija Jeftinija,Srdija Jeftinija,Philip G. Haydon +5 more
TL;DR: Astrocytes regulate neuronal calcium levels through the calcium-dependent release of glutamate, and an NMDA (N-methyl-d-aspartate) receptor-mediated increase in neuronal calcium is demonstrated.
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