Journal ArticleDOI
Pathophysiologic mechanisms of acute ischemic stroke: An overview with emphasis on therapeutic significance beyond thrombolysis
Reads0
Chats0
TLDR
The objective of this review is to critically evaluate the major mechanisms underlying stroke pathophysiology, with emphasis on potential novel targets for designing newer therapeutic modalities.About:
This article is published in Pathophysiology.The article was published on 2010-06-01. It has received 492 citations till now. The article focuses on the topics: Ischemic cascade & Stroke.read more
Citations
More filters
Journal ArticleDOI
Reactive Oxygen Species in Metabolic and Inflammatory Signaling.
TL;DR: The role of ROS in the regulation metabolic/inflammatory diseases including atherosclerosis, diabetes mellitus, and stroke is highlighted and the balance ROS signaling plays in both physiology and pathophysiology is understood.
Journal ArticleDOI
The Pharmacological Potential of Rutin.
Aditya Ganeshpurkar,Ajay Saluja +1 more
TL;DR: The present review highlights current information and health-promoting effects of rutin and safety pharmacology issues and SAR of the same have also been discussed.
Journal ArticleDOI
Stroke and the immune system: from pathophysiology to new therapeutic strategies
Richard Macrez,Carine Ali,Olivier Toutirais,Brigitte Le Mauff,Gilles Defer,Ulrich Dirnagl,Denis Vivien +6 more
TL;DR: Development of novel and effective therapeutic strategies for stroke will require further investigation of pathways in the immune system and inflammatory responses in terms of their temporal profile (before, during, and after stroke) and risk-to-benefit therapeutic ratio of modulating them.
Journal ArticleDOI
The role of extracellular histone in organ injury
TL;DR: Drugs that block the release of histone, neutralise circulating histone or block histone signal transduction provide significant protection from mortality in animal models of acute organ injury but warrant further research to inform future clinical applications.
Journal ArticleDOI
Angiogenesis, neurogenesis and neuroplasticity in ischemic stroke.
TL;DR: These findings suggest that blood vessels play an important role as a scaffold for NPCs migration toward the damaged brain region, and the origin of newly formed vessels and the pathogenic role of neovascularization and neurogenesis are important unresolved issues in the understanding of the mechanisms after stroke.
References
More filters
Journal ArticleDOI
Interleukin-6 and interleukin-1 receptor antagonist in acute stroke.
Nancy B. Beamer,Nancy B. Beamer,Bruce M. Coull,Bruce M. Coull,Wayne M. Clark,J. Samantha Hazel,Jenny R. Silberger +6 more
TL;DR: The role of pre-existing infection in acute phase response in stroke has been controversial, with some studies suggesting that preexisting infection accounts for most of the acute phase responses.
Journal ArticleDOI
Stroke prevention therapy beyond antithrombotics: unifying mechanisms in ischemic stroke pathogenesis and implications for therapy: an invited review.
TL;DR: Beyond the traditional antithrombotic agents, statin agents, angiotensin-converting enzyme inhibitors, and vitamins may prove to be important additions to the armamentarium for stroke prevention.
Journal ArticleDOI
Frequency of thrombolytic therapy in patients with acute ischemic stroke and the risk of in-hospital mortality: the German Stroke Registers Study Group.
Peter U. Heuschmann,Klaus Berger,Bjoern Misselwitz,Peter Hermanek,C Leffmann,Michael Adelmann,Hans-Joachim Buecker-Nott,Joachim Röther,Bernhard Neundoerfer,Peter L. Kolominsky-Rabas +9 more
TL;DR: It is suggested that thrombolytic therapy in hospitals with limited experience in its application increase the risk of in-hospital mortality.
Journal ArticleDOI
Tissue plasminogen activator promotes matrix metalloproteinase-9 upregulation after focal cerebral ischemia
Kiyoshi Tsuji,Toshiaki Aoki,Emiri Tejima,Ken Arai,Sun-Ryung Lee,Dmitriy N. Atochin,Paul L. Huang,Xiaoying Wang,Joan Montaner,Eng H. Lo +9 more
TL;DR: These data demonstrate that tPA upregulates brain MMP-9 levels in stroke in vivo, and suggest that combination therapies targeting MMPs may improve tPA therapy.
Related Papers (5)
Reversible middle cerebral artery occlusion without craniectomy in rats.
Pathobiology of ischaemic stroke: an integrated view
The Science of Stroke: Mechanisms in Search of Treatments
Guidelines for the Early Management of Patients With Acute Ischemic Stroke A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association
William J. Powers,Alejandro A. Rabinstein,Teri Ackerson,Opeolu Adeoye,Nicholas C. Bambakidis,Kyra J. Becker,José Biller,Michael D. Brown,Bart M. Demaerschalk,Brian L. Hoh,Edward C. Jauch,Chelsea S. Kidwell,Thabele M Leslie-Mazwi,Bruce Ovbiagele,Phillip A. Scott,Kevin N. Sheth,Andrew M. Southerland,Deborah V. Summers,David L. Tirschwell +18 more