Journal ArticleDOI
Pathophysiologic mechanisms of acute ischemic stroke: An overview with emphasis on therapeutic significance beyond thrombolysis
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TLDR
The objective of this review is to critically evaluate the major mechanisms underlying stroke pathophysiology, with emphasis on potential novel targets for designing newer therapeutic modalities.About:
This article is published in Pathophysiology.The article was published on 2010-06-01. It has received 492 citations till now. The article focuses on the topics: Ischemic cascade & Stroke.read more
Citations
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Journal ArticleDOI
Reactive Oxygen Species in Metabolic and Inflammatory Signaling.
TL;DR: The role of ROS in the regulation metabolic/inflammatory diseases including atherosclerosis, diabetes mellitus, and stroke is highlighted and the balance ROS signaling plays in both physiology and pathophysiology is understood.
Journal ArticleDOI
The Pharmacological Potential of Rutin.
Aditya Ganeshpurkar,Ajay Saluja +1 more
TL;DR: The present review highlights current information and health-promoting effects of rutin and safety pharmacology issues and SAR of the same have also been discussed.
Journal ArticleDOI
Stroke and the immune system: from pathophysiology to new therapeutic strategies
Richard Macrez,Carine Ali,Olivier Toutirais,Brigitte Le Mauff,Gilles Defer,Ulrich Dirnagl,Denis Vivien +6 more
TL;DR: Development of novel and effective therapeutic strategies for stroke will require further investigation of pathways in the immune system and inflammatory responses in terms of their temporal profile (before, during, and after stroke) and risk-to-benefit therapeutic ratio of modulating them.
Journal ArticleDOI
The role of extracellular histone in organ injury
TL;DR: Drugs that block the release of histone, neutralise circulating histone or block histone signal transduction provide significant protection from mortality in animal models of acute organ injury but warrant further research to inform future clinical applications.
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Angiogenesis, neurogenesis and neuroplasticity in ischemic stroke.
TL;DR: These findings suggest that blood vessels play an important role as a scaffold for NPCs migration toward the damaged brain region, and the origin of newly formed vessels and the pathogenic role of neovascularization and neurogenesis are important unresolved issues in the understanding of the mechanisms after stroke.
References
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Journal ArticleDOI
The coagulation factor V Leiden, MTHFRC677T variant and eNOS 4ab polymorphism in young Chinese population with ischemic stroke.
TL;DR: The eNOS 4ab variant appears to be an important risk factor for ischemic stroke in young Chinese population, according to the main goal of the current investigation.
Journal ArticleDOI
Early inflammatory response in ischemic stroke.
TL;DR: It is suggested that activation of the coagulation/fibrinolysis system and platelets may be in part related to the onset of stroke in patients with increased CRP levels, and the relationship of inflammatory response with hemostatic markers is discussed.
Journal ArticleDOI
Actualización en hemorragia cerebral espontánea
TL;DR: La hemorragia cerebral espontanea no aneurismatica o hemorrhragia intracraneal supone el 10-15% of todos los ictus y segun su localizacion puede ser intraparenquimatosa o intraventricular, y la etiologia predominante es the hipertension arterial mal controlada.
Journal ArticleDOI
Cerebrovascular Endothelin Receptor Upregulation in Cerebral Ischemia
TL;DR: The results from this work provide new perspectives on the pathophysiology of ischemic stroke, and give a possible explanation to the beneficial effects of treatment with PKC and MAPK inhibitors to limit the infarct volume.
Journal ArticleDOI
Inhibition of neurogenic inflammation as a novel treatment for ischemic stroke.
Renée J. Turner,Robert Vink +1 more
TL;DR: The current review summarizes the evidence supporting the benefits of inhibiting neurogenic inflammation to treat ischemic stroke and shows that substance P antagonists administered after the insult are efficacious in reducing post-stroke cerebral edema and neurological deficits.
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