Journal ArticleDOI
Pathophysiologic mechanisms of acute ischemic stroke: An overview with emphasis on therapeutic significance beyond thrombolysis
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TLDR
The objective of this review is to critically evaluate the major mechanisms underlying stroke pathophysiology, with emphasis on potential novel targets for designing newer therapeutic modalities.About:
This article is published in Pathophysiology.The article was published on 2010-06-01. It has received 492 citations till now. The article focuses on the topics: Ischemic cascade & Stroke.read more
Citations
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Journal ArticleDOI
Reactive Oxygen Species in Metabolic and Inflammatory Signaling.
TL;DR: The role of ROS in the regulation metabolic/inflammatory diseases including atherosclerosis, diabetes mellitus, and stroke is highlighted and the balance ROS signaling plays in both physiology and pathophysiology is understood.
Journal ArticleDOI
The Pharmacological Potential of Rutin.
Aditya Ganeshpurkar,Ajay Saluja +1 more
TL;DR: The present review highlights current information and health-promoting effects of rutin and safety pharmacology issues and SAR of the same have also been discussed.
Journal ArticleDOI
Stroke and the immune system: from pathophysiology to new therapeutic strategies
Richard Macrez,Carine Ali,Olivier Toutirais,Brigitte Le Mauff,Gilles Defer,Ulrich Dirnagl,Denis Vivien +6 more
TL;DR: Development of novel and effective therapeutic strategies for stroke will require further investigation of pathways in the immune system and inflammatory responses in terms of their temporal profile (before, during, and after stroke) and risk-to-benefit therapeutic ratio of modulating them.
Journal ArticleDOI
The role of extracellular histone in organ injury
TL;DR: Drugs that block the release of histone, neutralise circulating histone or block histone signal transduction provide significant protection from mortality in animal models of acute organ injury but warrant further research to inform future clinical applications.
Journal ArticleDOI
Angiogenesis, neurogenesis and neuroplasticity in ischemic stroke.
TL;DR: These findings suggest that blood vessels play an important role as a scaffold for NPCs migration toward the damaged brain region, and the origin of newly formed vessels and the pathogenic role of neovascularization and neurogenesis are important unresolved issues in the understanding of the mechanisms after stroke.
References
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Journal ArticleDOI
Systemic Inflammatory Parameters in Patients With Atherosclerosis of the Coronary and Peripheral Arteries
Michael Erren,Holger Reinecke,Ralf Junker,Manfred Fobker,Helmut Schulte,Josef O. Schurek,Jürgen Kropf,Sebastian Kerber,Günter Breithardt,Gerd Assmann,Paul Cullen +10 more
TL;DR: Increased plasma levels of CRP, SAA, IL-6, TGF-beta, neopterin, and procalcitonin constitute an inflammatory signature of advanced atherosclerosis and are correlated with the extent of disease but do not provide discriminatory diagnostic power over and above established risk factors.
Journal ArticleDOI
Caspase pathways, neuronal apoptosis, and CNS injury.
Basil A. Eldadah,Alan I. Faden +1 more
TL;DR: Evidence is provided for the potential therapeutic use of caspase inhibitors in the setting of acute and chronic CNS injury, and for their role in mediating cell death in chronic neurodegenerative conditions such as Alzheimer's disease, Huntington’s disease, and amyotrophic lateral sclerosis.
Journal ArticleDOI
Caspases as treatment targets in stroke and neurodegenerative diseases.
TL;DR: The evidence and the potential importance of caspase inhibition to cerebral ischemia are reviewed and an emerging body of data implicating caspases in cell death accompanying neurodegenerative disorders is summarized.
Journal ArticleDOI
Microglia and macrophages are the major source of tumor necrosis factor in permanent middle cerebral artery occlusion in mice
TL;DR: To a time-restricted microglial/macrophage production of TNF in focal cerebral ischemia in mice, nonradioactive in situ hybridization for murine TNF mRNA was performed and translation of T NF mRNA into bioactive protein was demonstrated in the neocortex of C57Bl/6 mice subjected to permanent middle cerebral artery occlusion.
Journal ArticleDOI
Cytosolic Calcium Oscillations in Astrocytes May Regulate Exocytotic Release of Glutamate
TL;DR: The fast activation of NMDARs in the sensor cells and the dependence of glutamate release on the functional integrity of both synaptobrevin and vacuolar H+ ATPase suggest that astrocytes are endowed with an exocytotic mechanism of glutamateRelease that resembles that of neurons.
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William J. Powers,Alejandro A. Rabinstein,Teri Ackerson,Opeolu Adeoye,Nicholas C. Bambakidis,Kyra J. Becker,José Biller,Michael D. Brown,Bart M. Demaerschalk,Brian L. Hoh,Edward C. Jauch,Chelsea S. Kidwell,Thabele M Leslie-Mazwi,Bruce Ovbiagele,Phillip A. Scott,Kevin N. Sheth,Andrew M. Southerland,Deborah V. Summers,David L. Tirschwell +18 more