Journal ArticleDOI
Pathophysiologic mechanisms of acute ischemic stroke: An overview with emphasis on therapeutic significance beyond thrombolysis
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TLDR
The objective of this review is to critically evaluate the major mechanisms underlying stroke pathophysiology, with emphasis on potential novel targets for designing newer therapeutic modalities.About:
This article is published in Pathophysiology.The article was published on 2010-06-01. It has received 492 citations till now. The article focuses on the topics: Ischemic cascade & Stroke.read more
Citations
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Journal ArticleDOI
Reactive Oxygen Species in Metabolic and Inflammatory Signaling.
TL;DR: The role of ROS in the regulation metabolic/inflammatory diseases including atherosclerosis, diabetes mellitus, and stroke is highlighted and the balance ROS signaling plays in both physiology and pathophysiology is understood.
Journal ArticleDOI
The Pharmacological Potential of Rutin.
Aditya Ganeshpurkar,Ajay Saluja +1 more
TL;DR: The present review highlights current information and health-promoting effects of rutin and safety pharmacology issues and SAR of the same have also been discussed.
Journal ArticleDOI
Stroke and the immune system: from pathophysiology to new therapeutic strategies
Richard Macrez,Carine Ali,Olivier Toutirais,Brigitte Le Mauff,Gilles Defer,Ulrich Dirnagl,Denis Vivien +6 more
TL;DR: Development of novel and effective therapeutic strategies for stroke will require further investigation of pathways in the immune system and inflammatory responses in terms of their temporal profile (before, during, and after stroke) and risk-to-benefit therapeutic ratio of modulating them.
Journal ArticleDOI
The role of extracellular histone in organ injury
TL;DR: Drugs that block the release of histone, neutralise circulating histone or block histone signal transduction provide significant protection from mortality in animal models of acute organ injury but warrant further research to inform future clinical applications.
Journal ArticleDOI
Angiogenesis, neurogenesis and neuroplasticity in ischemic stroke.
TL;DR: These findings suggest that blood vessels play an important role as a scaffold for NPCs migration toward the damaged brain region, and the origin of newly formed vessels and the pathogenic role of neovascularization and neurogenesis are important unresolved issues in the understanding of the mechanisms after stroke.
References
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Journal ArticleDOI
Functional Hemichannels in Astrocytes: A Novel Mechanism of Glutamate Release
TL;DR: It is shown that astrocytes in vitro express functional hemichannels that can mediate robust efflux of glutamate and aspartate and could influence CNS levels of extracellular glutamate with implications for normal and pathological brain function.
Journal ArticleDOI
Astrocytes contain a vesicular compartment that is competent for regulated exocytosis of glutamate
Paola Bezzi,Vidar Gundersen,Vidar Gundersen,José Luis Galbete,Gerald Seifert,Christian Steinhäuser,Ethel Pilati,Andrea Volterra,Andrea Volterra +8 more
TL;DR: The existence of a Ca2+-dependent quantal glutamate release activity in glia that was previously considered to be specific to synapses is document the existence of an astrocytic vesicular compartment that is competent for glutamate exocytosis.
Book
Cerebrospinal Fluid in Diseases of the Nervous System
TL;DR: The cerebrospinal fluid CSF findings in diseases of the nervous system lumbar puncture in clinical practice are found to be related to hydrocephalus, brain oedema, pseudotumour and related disorders.
Journal ArticleDOI
The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis
Armin Schneider,Carola Krüger,Tobias Steigleder,Tobias Steigleder,Tobias Steigleder,Daniela Weber,Claudia Pitzer,Rico Laage,Jaroslaw Aronowski,Martin H. Maurer,Nikolaus Gassler,Walter Mier,Martin Hasselblatt,Rainer Kollmar,Stefan Schwab,Clemens Sommer,Bach Alfred,Hans-Georg Kuhn,Hans-Georg Kuhn,Wolf Rüdiger Schäbitz,Wolf Rüdiger Schäbitz +20 more
TL;DR: G-CSF markedly improved long-term behavioral outcome after cortical ischemia, while stimulating neural progenitor response in vivo, providing a link to functional recovery, and is proposed as a potential new drug for stroke and neurodegenerative diseases.
Journal ArticleDOI
Inflammation and stroke: putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia.
Gregory J. del Zoppo,Irene Ginis,John M. Hallenbeck,Constantino Iadecola,Xinkang Wang,Giora Z. Feuerstein +5 more
TL;DR: Key data are summarized in support for the possibility that inflammatory cells and mediators are important contributing and confounding factors in ischemic brain injury and suggest that novel therapeutic strategies may evolve from detailed research on some specific inflammatory factors.
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