Journal ArticleDOI
Pathophysiologic mechanisms of acute ischemic stroke: An overview with emphasis on therapeutic significance beyond thrombolysis
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TLDR
The objective of this review is to critically evaluate the major mechanisms underlying stroke pathophysiology, with emphasis on potential novel targets for designing newer therapeutic modalities.About:
This article is published in Pathophysiology.The article was published on 2010-06-01. It has received 492 citations till now. The article focuses on the topics: Ischemic cascade & Stroke.read more
Citations
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Journal ArticleDOI
Mechanisms of Acupuncture Therapy in Ischemic Stroke Rehabilitation: A Literature Review of Basic Studies.
TL;DR: The findings show that acupuncture exerts a beneficial effect on ischemic stroke through modulation of different mechanisms originating in the CNS.
Journal ArticleDOI
Cell Death Pathways in Ischemic Stroke and Targeted Pharmacotherapy.
Aishika Datta,Deepaneeta Sarmah,Leela Mounica,Harpreet Kaur,Radhika Kesharwani,Geetesh Verma,Pabbala Veeresh,Vignesh Kotian,Kiran Kalia,Anupom Borah,Xin Wang,Kunjan R. Dave,Dileep R. Yavagal,Pallab Bhattacharya +13 more
TL;DR: Understanding the role of different cell death pathways is crucial to aid in the modern treatment of protecting apoptotic neurons and considers investigation on non-classical pathways that are tightly regulated, may or may not involve caspases, but non-apoptotic.
Journal ArticleDOI
GSK-3 as a Target for Lithium-Induced Neuroprotection Against Excitotoxicity in Neuronal Cultures and Animal Models of Ischemic Stroke
TL;DR: Together, GSK-3 inhibition is a rational strategy to combat ischemic stroke and other excitotoxicity-related brain disorders.
Journal ArticleDOI
Exercise influences hippocampal plasticity by modulating brain-derived neurotrophic factor processing.
TL;DR: In this paper, the effects of exercise on hippocampal plasticity were shown to be dependent on BDNF processing and subsequent TrkB signaling, with important implications for neuronal function, and they found that 7 days of voluntary exercise increased both pro and mature BDNF in rat hippocampus.
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Vagus nerve stimulation during rehabilitative training improves forelimb strength following ischemic stroke
Navid Khodaparast,Seth A. Hays,Andrew M. Sloan,Daniel R. Hulsey,Andrea Ruiz,Maritza Pantoja,Robert L. Rennaker,Michael P. Kilgard +7 more
TL;DR: It is reported that VNS paired with rehabilitative training can enhance recovery of forelimb force generation following infarction of primary motor cortex in rats and improved twice as much as rats that received the same rehabilitation without VNS.
References
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Journal ArticleDOI
Atherosclerosis — An Inflammatory Disease
TL;DR: Atherosclerosis is an inflammatory disease as discussed by the authors, and it is a major cause of death in the United States, Europe, and much of Asia, despite changes in lifestyle and use of new pharmacologic approaches to lower plasma cholesterol concentrations.
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Direct Proinflammatory Effect of C-Reactive Protein on Human Endothelial Cells
TL;DR: The hypothesis that CRP may play a direct role in promoting the inflammatory component of atherosclerosis and present a potential target for the treatment of Atherosclerosis is supported.
Journal ArticleDOI
p53 Has a Direct Apoptogenic Role at the Mitochondria
Motohiro Mihara,Susan Erster,Alex Zaika,Oleksi Petrenko,Thomas Chittenden,Petr Pancoska,Ute M. Moll +6 more
TL;DR: Evidence that p53 translocation to the mitochondria occurs in vivo in irradiated thymocytes is provided and it is shown that the p53 protein can directly induce permeabilization of the outer mitochondrial membrane by forming complexes with the protective BclXL and Bcl2 proteins, resulting in cytochrome c release.
Journal ArticleDOI
Glutamate-mediated astrocyte-neuron signalling.
Vladimir Parpura,Trent A. Basarsky,Fang Liu,Ksenija Jeftinija,Srdija Jeftinija,Philip G. Haydon +5 more
TL;DR: Astrocytes regulate neuronal calcium levels through the calcium-dependent release of glutamate, and an NMDA (N-methyl-d-aspartate) receptor-mediated increase in neuronal calcium is demonstrated.
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