Journal ArticleDOI
Pathophysiologic mechanisms of acute ischemic stroke: An overview with emphasis on therapeutic significance beyond thrombolysis
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TLDR
The objective of this review is to critically evaluate the major mechanisms underlying stroke pathophysiology, with emphasis on potential novel targets for designing newer therapeutic modalities.About:
This article is published in Pathophysiology.The article was published on 2010-06-01. It has received 492 citations till now. The article focuses on the topics: Ischemic cascade & Stroke.read more
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Patent
Therapeutic treatments using centhaquin
TL;DR: In this article, methods of treating hypertension, pain, and resuscitative hemorrhagic shock using an adrenergic agent, like centhaquin, were disclosed, which treat mammals, including humans.
Book ChapterDOI
Stroke and Hypotensive Syndromes
TL;DR: A constantly growing body of evidence points at the close association between hypotension and stroke in the elderly and the clinical and pathophysiological meaning of hypotensive syndromes including the influence on the short- and long- term clinical outcome, therapy and rehabilitation success, and all day living of stroke patients.
Combination treatment with progesterone and rehabilitation training further promotes behavioral recovery after acute ischemic stroke in mice
TL;DR: In this article, the authors investigated whether combination treatment with progesterone and rehabilitation training would be more effective than monotherapy after cerebral ischemia after photothrombosis.
Journal ArticleDOI
Evaluation and Importance of Platelet Variability Index Diagnostic Value in Cerebrovacular Events
TL;DR: Giriş and Amaç as mentioned in this paper have also discussed the effect of hastalar's erken prognoz öngörüsünü yapmak önemlidir.
Book ChapterDOI
Green Tea with Its Active Compound EGCG for Acute Ischemic Stroke Treatment
TL;DR: In this article , the authors discuss the benefit of green tea in acute ischemic stroke and propose that green tea consumption can decrease stroke risk, but not many studies explain its benefit in treating acute stroke patients.
References
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Journal ArticleDOI
Atherosclerosis — An Inflammatory Disease
TL;DR: Atherosclerosis is an inflammatory disease as discussed by the authors, and it is a major cause of death in the United States, Europe, and much of Asia, despite changes in lifestyle and use of new pharmacologic approaches to lower plasma cholesterol concentrations.
Journal ArticleDOI
Direct Proinflammatory Effect of C-Reactive Protein on Human Endothelial Cells
TL;DR: The hypothesis that CRP may play a direct role in promoting the inflammatory component of atherosclerosis and present a potential target for the treatment of Atherosclerosis is supported.
Journal ArticleDOI
p53 Has a Direct Apoptogenic Role at the Mitochondria
Motohiro Mihara,Susan Erster,Alex Zaika,Oleksi Petrenko,Thomas Chittenden,Petr Pancoska,Ute M. Moll +6 more
TL;DR: Evidence that p53 translocation to the mitochondria occurs in vivo in irradiated thymocytes is provided and it is shown that the p53 protein can directly induce permeabilization of the outer mitochondrial membrane by forming complexes with the protective BclXL and Bcl2 proteins, resulting in cytochrome c release.
Journal ArticleDOI
Glutamate-mediated astrocyte-neuron signalling.
Vladimir Parpura,Trent A. Basarsky,Fang Liu,Ksenija Jeftinija,Srdija Jeftinija,Philip G. Haydon +5 more
TL;DR: Astrocytes regulate neuronal calcium levels through the calcium-dependent release of glutamate, and an NMDA (N-methyl-d-aspartate) receptor-mediated increase in neuronal calcium is demonstrated.
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William J. Powers,Alejandro A. Rabinstein,Teri Ackerson,Opeolu Adeoye,Nicholas C. Bambakidis,Kyra J. Becker,José Biller,Michael D. Brown,Bart M. Demaerschalk,Brian L. Hoh,Edward C. Jauch,Chelsea S. Kidwell,Thabele M Leslie-Mazwi,Bruce Ovbiagele,Phillip A. Scott,Kevin N. Sheth,Andrew M. Southerland,Deborah V. Summers,David L. Tirschwell +18 more