Journal ArticleDOI
Pathophysiologic mechanisms of acute ischemic stroke: An overview with emphasis on therapeutic significance beyond thrombolysis
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TLDR
The objective of this review is to critically evaluate the major mechanisms underlying stroke pathophysiology, with emphasis on potential novel targets for designing newer therapeutic modalities.About:
This article is published in Pathophysiology.The article was published on 2010-06-01. It has received 492 citations till now. The article focuses on the topics: Ischemic cascade & Stroke.read more
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Therapeutic potential of treatment with the flavonoid rutin after cortical focal ischemia in rats
Amélia Miranda Gomes Rodrigues,Fralini dos Santos Marcilio,Michelle Frazão Muzitano,Arthur Giraldi-Guimarães +3 more
TL;DR: The results suggest rutin as an efficient drug to treat brain ischemia since it was able to promote significant recovery of sensorimotor loss, which was correlated to the reduction of neurodegeneration in the periphery of cortical injury.
Journal ArticleDOI
Association of Neutrophil-to-Lymphocyte Ratio and Lymphocyte-to-Monocyte Ratio with Treatment Modalities of Acute Ischaemic Stroke: A Pilot Study
Milena Świtońska,Artur Słomka,Piotr Korbal,Natalia Piekuś-Słomka,Władysław Sinkiewicz,Paweł Sokal,Ewa Żekanowska +6 more
TL;DR: NLR in IS patients treated using thrombectomy following thrombolysis was markedly higher than that in other treatment groups, which was associated with increased severity of the disease in these patients, therefore, patients with higher NLR may be expected to have more severe stroke.
Journal ArticleDOI
SCH58261 the Selective Adenosine A 2A Receptor Blocker Modulates Ischemia Reperfusion Injury Following Bilateral Carotid Occlusion: Role of Inflammatory Mediators
TL;DR: Results from the present study point towards the importance of central blockade of adenosine A2A receptor in ameliorating hippocampal damage following IR injury by halting inflammatory cascades as well as modulating excitotoxicity.
Journal ArticleDOI
Multiple biomarkers covering distinct pathways for predicting outcomes after ischemic stroke.
Chongke Zhong,Zhengbao Zhu,Aili Wang,Tan Xu,Xiaoqing Bu,Hao Peng,Jingyuan Yang,Liyuan Han,Jing Chen,Tian Xu,Yanbo Peng,Jinchao Wang,Qunwei Li,Zhong Ju,Deqin Geng,Jiang He,Yonghong Zhang +16 more
TL;DR: Investigation of the prognostic significance of multiple novel biomarkers in combination after ischemic stroke found a clear gradient relationship between the numbers of elevated novel biomarker and risk of major disability, mortality, and vascular events.
Journal ArticleDOI
“Three Hits” Hypothesis for Developmental Origins of Health and Diseases in View of Cardiovascular Abnormalities
TL;DR: The “Three hits” hypothesis is proposed that highlights the importance of intrauterine and early postnatal factors as contributors to FOAD, which could be significant for early prevention and treatments of FOAD.
References
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Journal ArticleDOI
Atherosclerosis — An Inflammatory Disease
TL;DR: Atherosclerosis is an inflammatory disease as discussed by the authors, and it is a major cause of death in the United States, Europe, and much of Asia, despite changes in lifestyle and use of new pharmacologic approaches to lower plasma cholesterol concentrations.
Journal ArticleDOI
Direct Proinflammatory Effect of C-Reactive Protein on Human Endothelial Cells
TL;DR: The hypothesis that CRP may play a direct role in promoting the inflammatory component of atherosclerosis and present a potential target for the treatment of Atherosclerosis is supported.
Journal ArticleDOI
p53 Has a Direct Apoptogenic Role at the Mitochondria
Motohiro Mihara,Susan Erster,Alex Zaika,Oleksi Petrenko,Thomas Chittenden,Petr Pancoska,Ute M. Moll +6 more
TL;DR: Evidence that p53 translocation to the mitochondria occurs in vivo in irradiated thymocytes is provided and it is shown that the p53 protein can directly induce permeabilization of the outer mitochondrial membrane by forming complexes with the protective BclXL and Bcl2 proteins, resulting in cytochrome c release.
Journal ArticleDOI
Glutamate-mediated astrocyte-neuron signalling.
Vladimir Parpura,Trent A. Basarsky,Fang Liu,Ksenija Jeftinija,Srdija Jeftinija,Philip G. Haydon +5 more
TL;DR: Astrocytes regulate neuronal calcium levels through the calcium-dependent release of glutamate, and an NMDA (N-methyl-d-aspartate) receptor-mediated increase in neuronal calcium is demonstrated.
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