Journal ArticleDOI
Pathophysiologic mechanisms of acute ischemic stroke: An overview with emphasis on therapeutic significance beyond thrombolysis
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TLDR
The objective of this review is to critically evaluate the major mechanisms underlying stroke pathophysiology, with emphasis on potential novel targets for designing newer therapeutic modalities.About:
This article is published in Pathophysiology.The article was published on 2010-06-01. It has received 492 citations till now. The article focuses on the topics: Ischemic cascade & Stroke.read more
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Journal ArticleDOI
Caveolin-1 in Stroke Neuropathology and Neuroprotection: A Novel Molecular Therapeutic Target for Ischemic-Related Injury
Shanshan Wang,Brian P. Head +1 more
TL;DR: This review focuses on the pathophysiology of stroke (neuronal cell loss, defective blood brain barrier, microglia activation, and inflammation), the role of the membrane protein caveolin- 1 (Cav-1) in normal brain physiology and stroke-induced changes, and the potential therapeutic role of Cav-1 in recovery following stroke.
Journal ArticleDOI
Calcium Intake and Serum Calcium Level in Relation to the Risk of Ischemic Stroke: Findings from the REGARDS Study.
Daniel T. Dibaba,Pengcheng Xun,Alyce D. Fly,Aurelian Bidulescu,Cari Lewis Tsinovoi,Suzanne E. Judd,Leslie A. McClure,Mary Cushman,Frederick W. Unverzagt,Ka He +9 more
TL;DR: It is suggested that serum Ca has inverse and Ca intake has threshold effect like association with risk of ischemic stroke.
Journal ArticleDOI
Effect of L-pGlu-(1-benzyl)-l-His-l-Pro-NH2 against in-vitro and in-vivo models of cerebral ischemia and associated neurological disorders.
Satyendra K. Rajput,Arun K. Sharma,Chhuttan Lal Meena,Aditya B. Pant,Rahul Jain,Shyam S. Sharma +5 more
TL;DR: Evaluated thyrotropin-releasing hormone analogue L-pGlu-(1-benzyl)-l-His-l-Pro-NH2 shows neuroprotective effects against oxygen glucose deprivation, glutamate and H2O2 induced injury in pheochromocytoma cell lines and in-vivo ischemic injury in mice, and is found to be protective in two acute models of AD and PD.
Journal ArticleDOI
Sirt1 mediates improvement of isoflurane-induced memory impairment following hyperbaric oxygen preconditioning in middle-aged mice.
Hu Hong-qiang,Shu Mang-qiao,Xue Fen,Liu Shan-shan,Cao Hui-juan,Hou Wu-gang,Yan Wen-jun,Peng Zheng-wu +7 more
TL;DR: The results suggest that the application of HBO preconditioning is a useful treatment for PocD, and that Sirt1 may be a potential molecular target for POCD therapy.
Journal ArticleDOI
A NMR-Based Metabonomics Approach to Determine Protective Effect of a Combination of Multiple Components Derived from Naodesheng on Ischemic Stroke Rats
TL;DR: Results showed that TCNDS could improve neurobehavioral function, decrease the cerebral infarct area, and ameliorate pathological features in MCAO model rats, and evidence that an NMR-based metabonomics approach integrated with biochemical assessment can help to better understand the underlying mechanisms as well as the holistic effect of multiple compounds from TCM.
References
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Journal ArticleDOI
Atherosclerosis — An Inflammatory Disease
TL;DR: Atherosclerosis is an inflammatory disease as discussed by the authors, and it is a major cause of death in the United States, Europe, and much of Asia, despite changes in lifestyle and use of new pharmacologic approaches to lower plasma cholesterol concentrations.
Journal ArticleDOI
Direct Proinflammatory Effect of C-Reactive Protein on Human Endothelial Cells
TL;DR: The hypothesis that CRP may play a direct role in promoting the inflammatory component of atherosclerosis and present a potential target for the treatment of Atherosclerosis is supported.
Journal ArticleDOI
p53 Has a Direct Apoptogenic Role at the Mitochondria
Motohiro Mihara,Susan Erster,Alex Zaika,Oleksi Petrenko,Thomas Chittenden,Petr Pancoska,Ute M. Moll +6 more
TL;DR: Evidence that p53 translocation to the mitochondria occurs in vivo in irradiated thymocytes is provided and it is shown that the p53 protein can directly induce permeabilization of the outer mitochondrial membrane by forming complexes with the protective BclXL and Bcl2 proteins, resulting in cytochrome c release.
Journal ArticleDOI
Glutamate-mediated astrocyte-neuron signalling.
Vladimir Parpura,Trent A. Basarsky,Fang Liu,Ksenija Jeftinija,Srdija Jeftinija,Philip G. Haydon +5 more
TL;DR: Astrocytes regulate neuronal calcium levels through the calcium-dependent release of glutamate, and an NMDA (N-methyl-d-aspartate) receptor-mediated increase in neuronal calcium is demonstrated.
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