Journal ArticleDOI
Pathophysiologic mechanisms of acute ischemic stroke: An overview with emphasis on therapeutic significance beyond thrombolysis
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TLDR
The objective of this review is to critically evaluate the major mechanisms underlying stroke pathophysiology, with emphasis on potential novel targets for designing newer therapeutic modalities.About:
This article is published in Pathophysiology.The article was published on 2010-06-01. It has received 492 citations till now. The article focuses on the topics: Ischemic cascade & Stroke.read more
Citations
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Journal ArticleDOI
Cell Death Mechanisms in Cerebral Ischemia–Reperfusion Injury
Journal ArticleDOI
Astrocytes Protect Neurons in the Hippocampal CA3 Against Ischemia by Suppressing the Intracellular Ca2+ Overload.
TL;DR: Astrocytes in the hippocampal CA3 region exert neuroprotective effects following transient forebrain ischemia and act by suppressing the intracellular Ca2+ overload, which will most likely provide a new therapeutic strategy for brain ischemic diseases, targeted to astrocyte.
Journal ArticleDOI
Treadmill exercise attenuates cerebral ischaemic injury in rats by protecting mitochondrial function via enhancement of caveolin-1.
Guoyuan Pan,Huimei Zhang,Anqi Zhu,Yao Lin,Lili Zhang,Bingyun Ye,Jingyan Cheng,Weimin Shen,Lingqin Jin,Chan Liu,Qingfeng Xie,Xiang Chen +11 more
TL;DR: Treadmill exercise protected mitochondrial integrity and inhibited the endogenous mitochondrial apoptosis pathway, and the damage of cerebral ischaemia was alleviated in rats through enhancement of caveolin-1 by treadmill exercise.
Book ChapterDOI
Iron Pathophysiology in Stroke.
TL;DR: Recent research progress in iron pathophysiology following cerebral stroke is discussed, focusing molecular regulation of iron metabolism and potential treatment targets.
Journal ArticleDOI
Meta-analysis study to evaluate the association of MTHFR C677T polymorphism with risk of ischemic stroke.
TL;DR: A meta-analysis of existing published studies found that there was a 30% higher risk of Ischemic stroke in the presence of MTHFR C667T mutation compared to controls, and Publication bias in the study was analyzed using funnel plot which revealed that only 7 studies out of the 72 contributed to publication bias.
References
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Journal ArticleDOI
Atherosclerosis — An Inflammatory Disease
TL;DR: Atherosclerosis is an inflammatory disease as discussed by the authors, and it is a major cause of death in the United States, Europe, and much of Asia, despite changes in lifestyle and use of new pharmacologic approaches to lower plasma cholesterol concentrations.
Journal ArticleDOI
Direct Proinflammatory Effect of C-Reactive Protein on Human Endothelial Cells
TL;DR: The hypothesis that CRP may play a direct role in promoting the inflammatory component of atherosclerosis and present a potential target for the treatment of Atherosclerosis is supported.
Journal ArticleDOI
p53 Has a Direct Apoptogenic Role at the Mitochondria
Motohiro Mihara,Susan Erster,Alex Zaika,Oleksi Petrenko,Thomas Chittenden,Petr Pancoska,Ute M. Moll +6 more
TL;DR: Evidence that p53 translocation to the mitochondria occurs in vivo in irradiated thymocytes is provided and it is shown that the p53 protein can directly induce permeabilization of the outer mitochondrial membrane by forming complexes with the protective BclXL and Bcl2 proteins, resulting in cytochrome c release.
Journal ArticleDOI
Glutamate-mediated astrocyte-neuron signalling.
Vladimir Parpura,Trent A. Basarsky,Fang Liu,Ksenija Jeftinija,Srdija Jeftinija,Philip G. Haydon +5 more
TL;DR: Astrocytes regulate neuronal calcium levels through the calcium-dependent release of glutamate, and an NMDA (N-methyl-d-aspartate) receptor-mediated increase in neuronal calcium is demonstrated.
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William J. Powers,Alejandro A. Rabinstein,Teri Ackerson,Opeolu Adeoye,Nicholas C. Bambakidis,Kyra J. Becker,José Biller,Michael D. Brown,Bart M. Demaerschalk,Brian L. Hoh,Edward C. Jauch,Chelsea S. Kidwell,Thabele M Leslie-Mazwi,Bruce Ovbiagele,Phillip A. Scott,Kevin N. Sheth,Andrew M. Southerland,Deborah V. Summers,David L. Tirschwell +18 more