Journal ArticleDOI
Pathophysiologic mechanisms of acute ischemic stroke: An overview with emphasis on therapeutic significance beyond thrombolysis
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TLDR
The objective of this review is to critically evaluate the major mechanisms underlying stroke pathophysiology, with emphasis on potential novel targets for designing newer therapeutic modalities.About:
This article is published in Pathophysiology.The article was published on 2010-06-01. It has received 492 citations till now. The article focuses on the topics: Ischemic cascade & Stroke.read more
Citations
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Potential neuroprotection of protodioscin against cerebral ischemia-reperfusion injury in rats through intervening inflammation and apoptosis
TL;DR: Findings demonstrated that protodioscin appeared to reveal potential neuroprotection against the I/R injury due to its anti-inflammatory and anti-apoptosis properties, probably mediated by the inactivation of NF-κB signal pathways.
Journal Article
Cerebral Ischemic Stroke: Sequels of Cascade
TL;DR: There is clear understanding of ischemic cascade followed by the mechanism of all damaging factors like energy failure, excitotoxicity, oxidative stress, neuroinflammation, cell death modes: necrosis, apoptosis along with histological changes.
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Monitoring Acute Stroke Progression: Multi-Parametric OCT Imaging of Cortical Perfusion, Flow, and Tissue Scattering in a Mouse Model of Permanent Focal Ischemia
TL;DR: The use of multi-parametric OCT imaging may aid in the comprehensive evaluation of ischemic lesions during the early stages of stroke, thereby providing essential knowledge for guiding treatment decisions.
Journal ArticleDOI
Pathophysiological and clinical considerations in the perioperative care of patients with a previous ischaemic stroke: a multidisciplinary narrative review
Jatinder S. Minhas,William Rook,Ronney B. Panerai,Ronney B. Panerai,Ryan L. Hoiland,Phil N. Ainslie,Jonathan P. Thompson,Jonathan P. Thompson,Amit K Mistri,Thompson G. Robinson,Thompson G. Robinson +10 more
TL;DR: This review describes the key pathophysiological and clinical considerations that inform clinicians providing perioperative care for patients with a prior diagnosis of stroke.
Journal ArticleDOI
Nanomaterials in Stroke Treatment: Perspectives
TL;DR: Major approaches developed to treat acute ischemic stroke fall into 2 categories, early recanalization (thrombolysis) and neuroprotection, which are achieved by blocking of proinflammatory cytokines and cell adhesion agents, decrease of lipid peroxidation processes, and blocking of apoptosis.
References
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Journal ArticleDOI
Atherosclerosis — An Inflammatory Disease
TL;DR: Atherosclerosis is an inflammatory disease as discussed by the authors, and it is a major cause of death in the United States, Europe, and much of Asia, despite changes in lifestyle and use of new pharmacologic approaches to lower plasma cholesterol concentrations.
Journal ArticleDOI
Direct Proinflammatory Effect of C-Reactive Protein on Human Endothelial Cells
TL;DR: The hypothesis that CRP may play a direct role in promoting the inflammatory component of atherosclerosis and present a potential target for the treatment of Atherosclerosis is supported.
Journal ArticleDOI
p53 Has a Direct Apoptogenic Role at the Mitochondria
Motohiro Mihara,Susan Erster,Alex Zaika,Oleksi Petrenko,Thomas Chittenden,Petr Pancoska,Ute M. Moll +6 more
TL;DR: Evidence that p53 translocation to the mitochondria occurs in vivo in irradiated thymocytes is provided and it is shown that the p53 protein can directly induce permeabilization of the outer mitochondrial membrane by forming complexes with the protective BclXL and Bcl2 proteins, resulting in cytochrome c release.
Journal ArticleDOI
Glutamate-mediated astrocyte-neuron signalling.
Vladimir Parpura,Trent A. Basarsky,Fang Liu,Ksenija Jeftinija,Srdija Jeftinija,Philip G. Haydon +5 more
TL;DR: Astrocytes regulate neuronal calcium levels through the calcium-dependent release of glutamate, and an NMDA (N-methyl-d-aspartate) receptor-mediated increase in neuronal calcium is demonstrated.
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William J. Powers,Alejandro A. Rabinstein,Teri Ackerson,Opeolu Adeoye,Nicholas C. Bambakidis,Kyra J. Becker,José Biller,Michael D. Brown,Bart M. Demaerschalk,Brian L. Hoh,Edward C. Jauch,Chelsea S. Kidwell,Thabele M Leslie-Mazwi,Bruce Ovbiagele,Phillip A. Scott,Kevin N. Sheth,Andrew M. Southerland,Deborah V. Summers,David L. Tirschwell +18 more