Journal ArticleDOI
Pathophysiologic mechanisms of acute ischemic stroke: An overview with emphasis on therapeutic significance beyond thrombolysis
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TLDR
The objective of this review is to critically evaluate the major mechanisms underlying stroke pathophysiology, with emphasis on potential novel targets for designing newer therapeutic modalities.About:
This article is published in Pathophysiology.The article was published on 2010-06-01. It has received 492 citations till now. The article focuses on the topics: Ischemic cascade & Stroke.read more
Citations
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Nitric oxide as a regulatory factor for aquaporin-1 and 4 gene expression following brain ischemia/reperfusion injury in rat
TL;DR: In this article, the authors evaluated the NO modulation of AQPs gene expression after brain ischemia/reperfusion (I/R) injury in rat, and found that brain I/R injury provokes brain edema by alterations of AQP expression, and the NO is the main signaling factor that modulates gene expression of these channels.
Acidente vascular encefálico: flavonoides como possível estratégia neuroprotetora
TL;DR: Algumas informacoes aree descrevemos sobre o acidente vascular encefalico e sua fisiopatologia, os processos neuroinflamatorios decorrentes, como liberacao de oxido nitrico e ativacao da glia e as acoes terapeuticas dos flavonoides.
Targeting the Pyk2/MCU Pathway, Ruthenium Red and Nimodipne Alone and in Combination Evoked NeuroProtective Effect in Experimentally Induced Brain Stroke
TL;DR: This is the first study to reveal the neuroprotective effects of RR, NMD and their combination in cerebral brain stroke model and improved cerebral blood flow through down regulation of Pyk2 and MCU gene expression in brain tissue.
Journal Article
Association of Hypoxia-Inducible Factor 1-α and Vascular Endothelial Growth Factor with Acute Ischemic Stroke Outcome
TL;DR: This study aimed to measure the association HIF-1α and VEGF level with clinical outcomes in acute ischemic stroke.
References
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Atherosclerosis — An Inflammatory Disease
TL;DR: Atherosclerosis is an inflammatory disease as discussed by the authors, and it is a major cause of death in the United States, Europe, and much of Asia, despite changes in lifestyle and use of new pharmacologic approaches to lower plasma cholesterol concentrations.
Journal ArticleDOI
Direct Proinflammatory Effect of C-Reactive Protein on Human Endothelial Cells
TL;DR: The hypothesis that CRP may play a direct role in promoting the inflammatory component of atherosclerosis and present a potential target for the treatment of Atherosclerosis is supported.
Journal ArticleDOI
p53 Has a Direct Apoptogenic Role at the Mitochondria
Motohiro Mihara,Susan Erster,Alex Zaika,Oleksi Petrenko,Thomas Chittenden,Petr Pancoska,Ute M. Moll +6 more
TL;DR: Evidence that p53 translocation to the mitochondria occurs in vivo in irradiated thymocytes is provided and it is shown that the p53 protein can directly induce permeabilization of the outer mitochondrial membrane by forming complexes with the protective BclXL and Bcl2 proteins, resulting in cytochrome c release.
Journal ArticleDOI
Glutamate-mediated astrocyte-neuron signalling.
Vladimir Parpura,Trent A. Basarsky,Fang Liu,Ksenija Jeftinija,Srdija Jeftinija,Philip G. Haydon +5 more
TL;DR: Astrocytes regulate neuronal calcium levels through the calcium-dependent release of glutamate, and an NMDA (N-methyl-d-aspartate) receptor-mediated increase in neuronal calcium is demonstrated.
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