Journal ArticleDOI
Pathophysiologic mechanisms of acute ischemic stroke: An overview with emphasis on therapeutic significance beyond thrombolysis
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TLDR
The objective of this review is to critically evaluate the major mechanisms underlying stroke pathophysiology, with emphasis on potential novel targets for designing newer therapeutic modalities.About:
This article is published in Pathophysiology.The article was published on 2010-06-01. It has received 492 citations till now. The article focuses on the topics: Ischemic cascade & Stroke.read more
Citations
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Journal ArticleDOI
Targeting endothelin receptors for pharmacotherapy of ischemic stroke: current scenario and future perspectives
TL;DR: A meta-analysis of all studies showed a significant reduction in the lesion volume and improvement in functional outcome in focal cerebral ischemia in stroke models with ET(A) receptor antagonists.
Journal ArticleDOI
Fourier-Transform Infrared Imaging Spectroscopy and Laser Ablation -ICPMS New Vistas for Biochemical Analyses of Ischemic Stroke in Rat Brain.
Mohamed H. M. Ali,Fazle Rakib,Essam M. Abdelalim,Essam M. Abdelalim,Andreas Limbeck,Raghvendra Mall,Ehsan Ullah,Nasrin Mesaeli,Donald McNaughton,Tariq Ahmed,Khalid Al-Saad +10 more
TL;DR: FTIR bio-spectroscopy is a non-destructive, rapid, and a refined technique to characterize oxidative stress markers associated with lipid degradation and protein denaturation not characterized by routine approaches, which may expedite research into stroke and offer new approaches for neurodegenerative disorders.
Journal ArticleDOI
Dynamic Changes in the Gut Microbiome at the Acute Stage of Ischemic Stroke in a Pig Model
Julie Jeon,Jeferson M. Lourenco,Erin E. Kaiser,Elizabeth S. Waters,Kelly M. Scheulin,Xi Fang,Holly A. Kinder,Simon R. Platt,Michael J. Rothrock,Todd R. Callaway,Franklin D. West,Hea Jin Park +11 more
TL;DR: Investigating the changes in the gut microbiota composition and diversity using a middle cerebral artery occlusion ischemic stroke pig model provides a basis for characterizing gut microbial changes during the acute stage of stroke, which can be used to assess stroke pathology and the potential development of therapeutic targets.
Proceedings ArticleDOI
An adaptive complementary filter for inertial sensor based data fusion to track upper body motion
TL;DR: In this article, an adaptive complementary filter and inertial measurement sensors are used to identify human upper arm movements. And the proposed algorithm is tested with four healthy subjects wearing an inertial sensor against gold standard, which is the VICON system.
Journal ArticleDOI
Cellular replacement and regenerative medicine therapies in ischemic stroke.
TL;DR: This review will address currently available therapies and focus on the application and potential of cell replacement, including stem cells and immortalized cell line-derived neurons as regenerative therapies for ischemic stroke, addressing current advances and challenges ahead.
References
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Journal ArticleDOI
Atherosclerosis — An Inflammatory Disease
TL;DR: Atherosclerosis is an inflammatory disease as discussed by the authors, and it is a major cause of death in the United States, Europe, and much of Asia, despite changes in lifestyle and use of new pharmacologic approaches to lower plasma cholesterol concentrations.
Journal ArticleDOI
Direct Proinflammatory Effect of C-Reactive Protein on Human Endothelial Cells
TL;DR: The hypothesis that CRP may play a direct role in promoting the inflammatory component of atherosclerosis and present a potential target for the treatment of Atherosclerosis is supported.
Journal ArticleDOI
p53 Has a Direct Apoptogenic Role at the Mitochondria
Motohiro Mihara,Susan Erster,Alex Zaika,Oleksi Petrenko,Thomas Chittenden,Petr Pancoska,Ute M. Moll +6 more
TL;DR: Evidence that p53 translocation to the mitochondria occurs in vivo in irradiated thymocytes is provided and it is shown that the p53 protein can directly induce permeabilization of the outer mitochondrial membrane by forming complexes with the protective BclXL and Bcl2 proteins, resulting in cytochrome c release.
Journal ArticleDOI
Glutamate-mediated astrocyte-neuron signalling.
Vladimir Parpura,Trent A. Basarsky,Fang Liu,Ksenija Jeftinija,Srdija Jeftinija,Philip G. Haydon +5 more
TL;DR: Astrocytes regulate neuronal calcium levels through the calcium-dependent release of glutamate, and an NMDA (N-methyl-d-aspartate) receptor-mediated increase in neuronal calcium is demonstrated.
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