Journal ArticleDOI
Pathophysiologic mechanisms of acute ischemic stroke: An overview with emphasis on therapeutic significance beyond thrombolysis
Reads0
Chats0
TLDR
The objective of this review is to critically evaluate the major mechanisms underlying stroke pathophysiology, with emphasis on potential novel targets for designing newer therapeutic modalities.About:
This article is published in Pathophysiology.The article was published on 2010-06-01. It has received 492 citations till now. The article focuses on the topics: Ischemic cascade & Stroke.read more
Citations
More filters
Journal ArticleDOI
Reactive Oxygen Species in Metabolic and Inflammatory Signaling.
TL;DR: The role of ROS in the regulation metabolic/inflammatory diseases including atherosclerosis, diabetes mellitus, and stroke is highlighted and the balance ROS signaling plays in both physiology and pathophysiology is understood.
Journal ArticleDOI
The Pharmacological Potential of Rutin.
Aditya Ganeshpurkar,Ajay Saluja +1 more
TL;DR: The present review highlights current information and health-promoting effects of rutin and safety pharmacology issues and SAR of the same have also been discussed.
Journal ArticleDOI
Stroke and the immune system: from pathophysiology to new therapeutic strategies
Richard Macrez,Carine Ali,Olivier Toutirais,Brigitte Le Mauff,Gilles Defer,Ulrich Dirnagl,Denis Vivien +6 more
TL;DR: Development of novel and effective therapeutic strategies for stroke will require further investigation of pathways in the immune system and inflammatory responses in terms of their temporal profile (before, during, and after stroke) and risk-to-benefit therapeutic ratio of modulating them.
Journal ArticleDOI
The role of extracellular histone in organ injury
TL;DR: Drugs that block the release of histone, neutralise circulating histone or block histone signal transduction provide significant protection from mortality in animal models of acute organ injury but warrant further research to inform future clinical applications.
Journal ArticleDOI
Angiogenesis, neurogenesis and neuroplasticity in ischemic stroke.
TL;DR: These findings suggest that blood vessels play an important role as a scaffold for NPCs migration toward the damaged brain region, and the origin of newly formed vessels and the pathogenic role of neovascularization and neurogenesis are important unresolved issues in the understanding of the mechanisms after stroke.
References
More filters
Journal ArticleDOI
Apoptosis in neurodegenerative disorders
TL;DR: With the identification of mechanisms that either promote or prevent neuronal apoptosis come new approaches for preventing and treating neurodegenerative disorders.
Journal ArticleDOI
Current Concepts of the Pathogenesis of the Acute Coronary Syndromes
TL;DR: Knowledge of the underlying mechanisms has increased substantially since this topic was last reviewed in these pages 6 years ago and the present article provides an update of this rapidly moving field.
Journal ArticleDOI
Transcription Factor ATF2 Regulation by the JNK Signal Transduction Pathway
TL;DR: A role for the JNK signal transduction pathway in transcriptional responses mediated by ATF2 is demonstrated and mutations in this pathway inhibited ATF2-stimulated gene expression mediated by the retinoblastoma tumor suppressor and the adenovirus early region 1A (E1A) oncoprotein.
Journal ArticleDOI
Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death
Nicholas Joza,Nicholas Joza,Santos A. Susin,Eric Daugas,William L. Stanford,Sarah K. Cho,Carol Y. J. Li,Takehiko Sasaki,Takehiko Sasaki,Andrew J. Elia,H.-Y. Mary Cheng,H.-Y. Mary Cheng,Luigi Ravagnan,Karine F. Ferri,Naoufal Zamzami,Andrew Wakeham,Razqallah Hakem,Hiroki Yoshida,Young-Yun Kong,Tak W. Mak,Juan Carlos Zúñiga-Pflücker,Guido Kroemer,Josef M. Penninger,Josef M. Penninger +23 more
TL;DR: It is shown that genetic inactivation of AIF renders embryonic stem cells resistant to cell death after serum deprivation, providing genetic evidence for a caspase-independent pathway of programmed cell death that controls early morphogenesis.
Journal ArticleDOI
Apoptotic Mechanisms After Cerebral Ischemia
TL;DR: Accumulating evidence now indicates that apoptosis is prevalent in nonneuronal cells and that caspase-independent mechanisms also play a key role in the development of apoptosis in ischemic lesions.
Related Papers (5)
Reversible middle cerebral artery occlusion without craniectomy in rats.
Pathobiology of ischaemic stroke: an integrated view
The Science of Stroke: Mechanisms in Search of Treatments
Guidelines for the Early Management of Patients With Acute Ischemic Stroke A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association
William J. Powers,Alejandro A. Rabinstein,Teri Ackerson,Opeolu Adeoye,Nicholas C. Bambakidis,Kyra J. Becker,José Biller,Michael D. Brown,Bart M. Demaerschalk,Brian L. Hoh,Edward C. Jauch,Chelsea S. Kidwell,Thabele M Leslie-Mazwi,Bruce Ovbiagele,Phillip A. Scott,Kevin N. Sheth,Andrew M. Southerland,Deborah V. Summers,David L. Tirschwell +18 more