Journal ArticleDOI
Pathophysiologic mechanisms of acute ischemic stroke: An overview with emphasis on therapeutic significance beyond thrombolysis
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TLDR
The objective of this review is to critically evaluate the major mechanisms underlying stroke pathophysiology, with emphasis on potential novel targets for designing newer therapeutic modalities.About:
This article is published in Pathophysiology.The article was published on 2010-06-01. It has received 492 citations till now. The article focuses on the topics: Ischemic cascade & Stroke.read more
Citations
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Journal Article
Therapeutic role of phytoconstituents in treatment of cerebral ischemia/reperfusion injury
TL;DR: In this review, cascade pathway of stroke, role medicinal compounds and novel medical pathway and hypothesis protecting brain ischemia or delay the neurological disorders following a stroke are discussed.
Journal ArticleDOI
Circulating endothelial microvesicles and their carried miR-125a-5p: potential biomarkers for ischaemic stroke
Xiaotang Ma,Xiaorong Liao,Jiehong Liu,Yan Wang,Xiang Wang,Yanfang Chen,Xiaojian Yin,Qunwen Pan +7 more
TL;DR: It is demonstrated that circulating EMVs and EMV-miR-125a-5p are closely related with the occurrence, progress, subtypes and severity of IS, and they can serve as innovative biomarkers and therapeutic targets for IS, especially when they are combined.
Journal ArticleDOI
GAMBARAN PENGGUNAAN KONTRASEPSI HORMONAL PADA PASIEN STROKE ISKEMIK DI RSUD Dr. SOETOMO SURABAYA
TL;DR: Variabel penelitian meliputi usia, pekerjaan, riwayat penyakit, jenis dan lama penggunaan kontrasepsi hormonal, serta jarak berhenti penggunakan kentrasepSI hormonal sampai terjadinya stroke iskemik rata - rata <12 tahun.
Book ChapterDOI
The therapeutic potential of exogenous adult stem cells for the injured central nervous system
Jayden Smith,Alice Braga,Regan Hamel,Carola Rutigliani,Bryan Yu,Luca Peruzzotti-Jametti,Stefano Pluchino +6 more
TL;DR: Clinical translation has thus far been impeded by only modest efficacy outcomes in clinical trials, speaking to a need for greater consistency and controls in such studies.
References
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Journal ArticleDOI
Atherosclerosis — An Inflammatory Disease
TL;DR: Atherosclerosis is an inflammatory disease as discussed by the authors, and it is a major cause of death in the United States, Europe, and much of Asia, despite changes in lifestyle and use of new pharmacologic approaches to lower plasma cholesterol concentrations.
Journal ArticleDOI
Direct Proinflammatory Effect of C-Reactive Protein on Human Endothelial Cells
TL;DR: The hypothesis that CRP may play a direct role in promoting the inflammatory component of atherosclerosis and present a potential target for the treatment of Atherosclerosis is supported.
Journal ArticleDOI
p53 Has a Direct Apoptogenic Role at the Mitochondria
Motohiro Mihara,Susan Erster,Alex Zaika,Oleksi Petrenko,Thomas Chittenden,Petr Pancoska,Ute M. Moll +6 more
TL;DR: Evidence that p53 translocation to the mitochondria occurs in vivo in irradiated thymocytes is provided and it is shown that the p53 protein can directly induce permeabilization of the outer mitochondrial membrane by forming complexes with the protective BclXL and Bcl2 proteins, resulting in cytochrome c release.
Journal ArticleDOI
Glutamate-mediated astrocyte-neuron signalling.
Vladimir Parpura,Trent A. Basarsky,Fang Liu,Ksenija Jeftinija,Srdija Jeftinija,Philip G. Haydon +5 more
TL;DR: Astrocytes regulate neuronal calcium levels through the calcium-dependent release of glutamate, and an NMDA (N-methyl-d-aspartate) receptor-mediated increase in neuronal calcium is demonstrated.
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William J. Powers,Alejandro A. Rabinstein,Teri Ackerson,Opeolu Adeoye,Nicholas C. Bambakidis,Kyra J. Becker,José Biller,Michael D. Brown,Bart M. Demaerschalk,Brian L. Hoh,Edward C. Jauch,Chelsea S. Kidwell,Thabele M Leslie-Mazwi,Bruce Ovbiagele,Phillip A. Scott,Kevin N. Sheth,Andrew M. Southerland,Deborah V. Summers,David L. Tirschwell +18 more