Journal ArticleDOI
Pathophysiologic mechanisms of acute ischemic stroke: An overview with emphasis on therapeutic significance beyond thrombolysis
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TLDR
The objective of this review is to critically evaluate the major mechanisms underlying stroke pathophysiology, with emphasis on potential novel targets for designing newer therapeutic modalities.About:
This article is published in Pathophysiology.The article was published on 2010-06-01. It has received 492 citations till now. The article focuses on the topics: Ischemic cascade & Stroke.read more
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Inhaled Methane Protects Rats Against Neurological Dysfunction Induced by Cerebral Ischemia and Reperfusion Injury: PI3K/Akt/HO-1 Pathway Involved
TL;DR: This finding suggests the possible application of methane for cerebral I/R injury and PI3K/Akt/HO-1 dependent antioxidant pathway may be involved.
Journal ArticleDOI
Combination treatment with progesterone and rehabilitation training further promotes behavioral recovery after acute ischemic stroke in mice
TL;DR: It is suggested that combination treatment with progesterone and rehabilitation training had no additive effect in reducing infarct volume, but combination therapy exhibited enhanced efficacy in promoting functional recovery after ischemic stroke, suggesting progester one and rehabilitationTraining may exert their effects via different mechanisms.
Journal ArticleDOI
Pomalidomide Reduces Ischemic Brain Injury in Rodents
Yan Rou Tsai,David Tweedie,Ignacio Navas-Enamorado,Michael T. Scerba,Cheng Fu Chang,Jing Huei Lai,John Chung Che Wu,John Chung Che Wu,Yen Hua Chen,Shuo Jhen Kang,Barry J. Hoffer,Barry J. Hoffer,Rafael de Cabo,Nigel H. Greig,Yung Hsiao Chiang,Kai Yun Chen +15 more
TL;DR: POM’s neuroprotective actions on isChemic injury represent a potential therapeutic approach for ischemic brain damage and related disorders, and warrant further evaluation.
Journal ArticleDOI
Mitochondrial Quality and Quantity Control: Mitophagy Is a Potential Therapeutic Target for Ischemic Stroke
Meiying Song,Yuan Zhou,Xiang Fan +2 more
TL;DR: The dynamic changes and double-edged roles of mitochondria and related signaling pathways of mitophagy in the pathophysiology of ischemic stroke are discussed and the possibility of modulatingMitophagy as a potential therapy for the prevention and prognosis of isChemic stroke is focused on.
Journal ArticleDOI
Actualización en diagnóstico y tratamiento del ataque cerebrovascular isquémico agudo
Carolina García Alfonso,Andrea Martínez Reyes,Valentina García,Andrés Ricaurte-Fajardo,Isabel Cristina Salazar Torres,Juliana Coral +5 more
TL;DR: In el últimas años, el ataque cerebrovascular (ACV) agudo is the segunda causa de muerte en el worldo and genera costos elevados en su tratamiento and recuperación, así como un gran impacto socio-económico, pues es the principal cause de discapacidad a largo plazo as discussed by the authors.
References
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Journal ArticleDOI
Atherosclerosis — An Inflammatory Disease
TL;DR: Atherosclerosis is an inflammatory disease as discussed by the authors, and it is a major cause of death in the United States, Europe, and much of Asia, despite changes in lifestyle and use of new pharmacologic approaches to lower plasma cholesterol concentrations.
Journal ArticleDOI
Direct Proinflammatory Effect of C-Reactive Protein on Human Endothelial Cells
TL;DR: The hypothesis that CRP may play a direct role in promoting the inflammatory component of atherosclerosis and present a potential target for the treatment of Atherosclerosis is supported.
Journal ArticleDOI
p53 Has a Direct Apoptogenic Role at the Mitochondria
Motohiro Mihara,Susan Erster,Alex Zaika,Oleksi Petrenko,Thomas Chittenden,Petr Pancoska,Ute M. Moll +6 more
TL;DR: Evidence that p53 translocation to the mitochondria occurs in vivo in irradiated thymocytes is provided and it is shown that the p53 protein can directly induce permeabilization of the outer mitochondrial membrane by forming complexes with the protective BclXL and Bcl2 proteins, resulting in cytochrome c release.
Journal ArticleDOI
Glutamate-mediated astrocyte-neuron signalling.
Vladimir Parpura,Trent A. Basarsky,Fang Liu,Ksenija Jeftinija,Srdija Jeftinija,Philip G. Haydon +5 more
TL;DR: Astrocytes regulate neuronal calcium levels through the calcium-dependent release of glutamate, and an NMDA (N-methyl-d-aspartate) receptor-mediated increase in neuronal calcium is demonstrated.
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