Journal ArticleDOI
Pathophysiologic mechanisms of acute ischemic stroke: An overview with emphasis on therapeutic significance beyond thrombolysis
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TLDR
The objective of this review is to critically evaluate the major mechanisms underlying stroke pathophysiology, with emphasis on potential novel targets for designing newer therapeutic modalities.About:
This article is published in Pathophysiology.The article was published on 2010-06-01. It has received 492 citations till now. The article focuses on the topics: Ischemic cascade & Stroke.read more
Citations
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Journal ArticleDOI
Reactive Oxygen Species in Metabolic and Inflammatory Signaling.
TL;DR: The role of ROS in the regulation metabolic/inflammatory diseases including atherosclerosis, diabetes mellitus, and stroke is highlighted and the balance ROS signaling plays in both physiology and pathophysiology is understood.
Journal ArticleDOI
The Pharmacological Potential of Rutin.
Aditya Ganeshpurkar,Ajay Saluja +1 more
TL;DR: The present review highlights current information and health-promoting effects of rutin and safety pharmacology issues and SAR of the same have also been discussed.
Journal ArticleDOI
Stroke and the immune system: from pathophysiology to new therapeutic strategies
Richard Macrez,Carine Ali,Olivier Toutirais,Brigitte Le Mauff,Gilles Defer,Ulrich Dirnagl,Denis Vivien +6 more
TL;DR: Development of novel and effective therapeutic strategies for stroke will require further investigation of pathways in the immune system and inflammatory responses in terms of their temporal profile (before, during, and after stroke) and risk-to-benefit therapeutic ratio of modulating them.
Journal ArticleDOI
The role of extracellular histone in organ injury
TL;DR: Drugs that block the release of histone, neutralise circulating histone or block histone signal transduction provide significant protection from mortality in animal models of acute organ injury but warrant further research to inform future clinical applications.
Journal ArticleDOI
Angiogenesis, neurogenesis and neuroplasticity in ischemic stroke.
TL;DR: These findings suggest that blood vessels play an important role as a scaffold for NPCs migration toward the damaged brain region, and the origin of newly formed vessels and the pathogenic role of neovascularization and neurogenesis are important unresolved issues in the understanding of the mechanisms after stroke.
References
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Journal ArticleDOI
Apoptosis in neurodegenerative disorders
TL;DR: There is supportive, but not definitive, evidence for apoptosis in a number of neurodegenerative disorders, and tissue culture models, animal models and human pathological studies are discussed.
Journal ArticleDOI
The identification of vesicular glutamate transporter 3 suggests novel modes of signaling by glutamate.
Robert T. Fremeau,Jonathon L. Burman,Tayyaba Qureshi,Cindy H Tran,John Proctor,Juliette Johnson,Hui Zhang,David Sulzer,David R. Copenhagen,Jon Storm-Mathisen,Richard J. Reimer,Farrukh A. Chaudhry,Robert H. Edwards +12 more
TL;DR: The distribution and subcellular location of VGLUT3 suggest novel modes of signaling by glutamate, and the dendritic expression of V GLUT3 by particular neurons also indicates the potential for retrograde synaptic signaling.
Journal ArticleDOI
RANTES: a versatile and controversial chemokine
Victor Appay,Sarah Rowland-Jones +1 more
TL;DR: The activity of the chemokine RANTES is a powerful leukocyte activator, a feature potentially relevant in a range of inflammatory disorders and critically dependent on its ability to self-aggregate and bind to glycosaminoglycans.
Journal ArticleDOI
Matrix Metalloproteinases Increase Very Early During Experimental Focal Cerebral Ischemia
TL;DR: Findings highlight the early potential role of MMP-2 in the degradation of basal lamina leading to neuronal injury, and an association of M MP-9 with hemorrhagic transformation after focal cerebral ischemia, which is highly correlated with the extent of neuron injury and the number of injured neurons.
Journal ArticleDOI
Matrix Metalloproteinase-9 Pretreatment Level Predicts Intracranial Hemorrhagic Complications After Thrombolysis in Human Stroke
Joan Montaner,Carlos A. Molina,Jasone Monasterio,Sònia Abilleira,Juan F. Arenillas,Marc Ribo,Manolo Quintana,José Alvarez-Sabín +7 more
TL;DR: It is suggested that MMP determination may increase the safety profile for thrombolysis and, in the future, anti-MMP drugs might be combined with t-PA to prevent hemorrhagic complications.
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