Journal ArticleDOI
Pathophysiologic mechanisms of acute ischemic stroke: An overview with emphasis on therapeutic significance beyond thrombolysis
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TLDR
The objective of this review is to critically evaluate the major mechanisms underlying stroke pathophysiology, with emphasis on potential novel targets for designing newer therapeutic modalities.About:
This article is published in Pathophysiology.The article was published on 2010-06-01. It has received 492 citations till now. The article focuses on the topics: Ischemic cascade & Stroke.read more
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Journal ArticleDOI
Study on the Optimum Parameters of Alternating Magnetic Field Treatments against Cerebral Ischemia/Reperfusion Injury in Rats
Won Jong,Myong Hui Kim +1 more
TL;DR: Contribution ratio of frequency among parameters of alternating magnetic field is the highest for neuroprotective effects after the middle cerebral artery occlusion reperfusion injury in rats.
Journal ArticleDOI
Accidente cerebrovascular isquémico de la arteria cerebral media
TL;DR: In this paper , a revisión de la literatura mediante la búsqueda con términos MeSH in la base of datos Medline, incluyendo estudios, ensayos, and metaanálisis publicados entre 2000 and 2020 in inglés and español, además de otras referencias for complementar la información.
Journal ArticleDOI
Stimuli-Responsive Nanotherapeutics for Treatment and Diagnosis of Stroke
Manisha Choudhary,S. Chaudhari,Tanisha Gupta,Dnyaneshwar Kalyane,Bhagwat Sirsat,Umesh Kathar,Pinaki Sengupta,Rakesh K. Tekade +7 more
TL;DR: In this paper , a review of the basics of stroke, including its pathophysiology, factors affecting its development, current treatment therapies, and their limitations is presented, with challenges ahead for the safe use of nanotherapeutics.
Aplicación de células mesenquimales autólogas como adyuvante en el tratamiento de embolia cerebral
TL;DR: Cell therapy is a promising treatment is considered as a means to promote central nervous system repair in interaction with the sites of injury, promoting regeneration and inhibiting the effects of the infl ammatory process.
Book ChapterDOI
The Influence of Preconditioning on the Homing Behavior of Stem Cells
TL;DR: In this article , the authors discuss various strategies, such as preconditioning of stem cells (use of hypoxia, chemokine approaches, etc.), selecting the optimal time window, and route of delivery used to enhance stem cell homing ability in stroke.
References
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Journal ArticleDOI
Atherosclerosis — An Inflammatory Disease
TL;DR: Atherosclerosis is an inflammatory disease as discussed by the authors, and it is a major cause of death in the United States, Europe, and much of Asia, despite changes in lifestyle and use of new pharmacologic approaches to lower plasma cholesterol concentrations.
Journal ArticleDOI
Direct Proinflammatory Effect of C-Reactive Protein on Human Endothelial Cells
TL;DR: The hypothesis that CRP may play a direct role in promoting the inflammatory component of atherosclerosis and present a potential target for the treatment of Atherosclerosis is supported.
Journal ArticleDOI
p53 Has a Direct Apoptogenic Role at the Mitochondria
Motohiro Mihara,Susan Erster,Alex Zaika,Oleksi Petrenko,Thomas Chittenden,Petr Pancoska,Ute M. Moll +6 more
TL;DR: Evidence that p53 translocation to the mitochondria occurs in vivo in irradiated thymocytes is provided and it is shown that the p53 protein can directly induce permeabilization of the outer mitochondrial membrane by forming complexes with the protective BclXL and Bcl2 proteins, resulting in cytochrome c release.
Journal ArticleDOI
Glutamate-mediated astrocyte-neuron signalling.
Vladimir Parpura,Trent A. Basarsky,Fang Liu,Ksenija Jeftinija,Srdija Jeftinija,Philip G. Haydon +5 more
TL;DR: Astrocytes regulate neuronal calcium levels through the calcium-dependent release of glutamate, and an NMDA (N-methyl-d-aspartate) receptor-mediated increase in neuronal calcium is demonstrated.
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William J. Powers,Alejandro A. Rabinstein,Teri Ackerson,Opeolu Adeoye,Nicholas C. Bambakidis,Kyra J. Becker,José Biller,Michael D. Brown,Bart M. Demaerschalk,Brian L. Hoh,Edward C. Jauch,Chelsea S. Kidwell,Thabele M Leslie-Mazwi,Bruce Ovbiagele,Phillip A. Scott,Kevin N. Sheth,Andrew M. Southerland,Deborah V. Summers,David L. Tirschwell +18 more