Journal ArticleDOI
Pathophysiologic mechanisms of acute ischemic stroke: An overview with emphasis on therapeutic significance beyond thrombolysis
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TLDR
The objective of this review is to critically evaluate the major mechanisms underlying stroke pathophysiology, with emphasis on potential novel targets for designing newer therapeutic modalities.About:
This article is published in Pathophysiology.The article was published on 2010-06-01. It has received 492 citations till now. The article focuses on the topics: Ischemic cascade & Stroke.read more
Citations
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Journal ArticleDOI
Utility of intestinal intravital microscopy for the study of CNS injury-induced immunodepression syndrome (CIDS).
TL;DR: In this article, the photothrombotic stroke (PTS) model was used in C57BL/6 mice and its effects on peripheral immunity following challenge with lipopolysaccharide (LPS) were assessed using intestinal intravital microscopy (IVM).
Journal ArticleDOI
The Role of Extracellular Vesicles in Ischemic Stroke Severity
Angelica Carandina,Chiara Favero,Roberto M. Sacco,Mirjam Hoxha,G. Torgano,Nicola Montano,Valentina Bollati,Eleonora Tobaldini +7 more
TL;DR: It is found that specific extracellular vesicle subtypes are associated with stroke severity and both short- and long-term outcomes.
The Brain-Heart Connection: Establishment of a Novel Rodent Model of Focal Insular Ischemic Stroke to Examine the Pathophysiology of Stroke-Induced Heart Injury
TL;DR: This paper aims to provide a history of the field and some of the techniques used in its development, as well as some of its subsequent studies, to help clarify its origins.
Journal ArticleDOI
Erythropoietin Restores Motor Functions through Angiogenesis in the Thalamus Area of Ischemic Stroke in Rats
TL;DR: In this article, the potency of erythropoietin as angiogenesis inducer in ischemic stroke rats was evaluated in an animal model with right unilateral common carotid artery occlusion (rUCCAO) for 90 minutes.
Dissertation
"Frankov znak kao dermatološki marker ateroskleroze - usporedba pacijenata s preboljelim moždanim i srčanim udarom"
TL;DR: Dijagonalni nabor usne skoljke spominje se jos u renesansi, americki lijecnik Sonders T. Frank je opisao 1973.
References
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Journal ArticleDOI
Atherosclerosis — An Inflammatory Disease
TL;DR: Atherosclerosis is an inflammatory disease as discussed by the authors, and it is a major cause of death in the United States, Europe, and much of Asia, despite changes in lifestyle and use of new pharmacologic approaches to lower plasma cholesterol concentrations.
Journal ArticleDOI
Direct Proinflammatory Effect of C-Reactive Protein on Human Endothelial Cells
TL;DR: The hypothesis that CRP may play a direct role in promoting the inflammatory component of atherosclerosis and present a potential target for the treatment of Atherosclerosis is supported.
Journal ArticleDOI
p53 Has a Direct Apoptogenic Role at the Mitochondria
Motohiro Mihara,Susan Erster,Alex Zaika,Oleksi Petrenko,Thomas Chittenden,Petr Pancoska,Ute M. Moll +6 more
TL;DR: Evidence that p53 translocation to the mitochondria occurs in vivo in irradiated thymocytes is provided and it is shown that the p53 protein can directly induce permeabilization of the outer mitochondrial membrane by forming complexes with the protective BclXL and Bcl2 proteins, resulting in cytochrome c release.
Journal ArticleDOI
Glutamate-mediated astrocyte-neuron signalling.
Vladimir Parpura,Trent A. Basarsky,Fang Liu,Ksenija Jeftinija,Srdija Jeftinija,Philip G. Haydon +5 more
TL;DR: Astrocytes regulate neuronal calcium levels through the calcium-dependent release of glutamate, and an NMDA (N-methyl-d-aspartate) receptor-mediated increase in neuronal calcium is demonstrated.
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William J. Powers,Alejandro A. Rabinstein,Teri Ackerson,Opeolu Adeoye,Nicholas C. Bambakidis,Kyra J. Becker,José Biller,Michael D. Brown,Bart M. Demaerschalk,Brian L. Hoh,Edward C. Jauch,Chelsea S. Kidwell,Thabele M Leslie-Mazwi,Bruce Ovbiagele,Phillip A. Scott,Kevin N. Sheth,Andrew M. Southerland,Deborah V. Summers,David L. Tirschwell +18 more