Journal ArticleDOI
Pathophysiologic mechanisms of acute ischemic stroke: An overview with emphasis on therapeutic significance beyond thrombolysis
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TLDR
The objective of this review is to critically evaluate the major mechanisms underlying stroke pathophysiology, with emphasis on potential novel targets for designing newer therapeutic modalities.About:
This article is published in Pathophysiology.The article was published on 2010-06-01. It has received 492 citations till now. The article focuses on the topics: Ischemic cascade & Stroke.read more
Citations
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Journal ArticleDOI
Reactive Oxygen Species in Metabolic and Inflammatory Signaling.
TL;DR: The role of ROS in the regulation metabolic/inflammatory diseases including atherosclerosis, diabetes mellitus, and stroke is highlighted and the balance ROS signaling plays in both physiology and pathophysiology is understood.
Journal ArticleDOI
The Pharmacological Potential of Rutin.
Aditya Ganeshpurkar,Ajay Saluja +1 more
TL;DR: The present review highlights current information and health-promoting effects of rutin and safety pharmacology issues and SAR of the same have also been discussed.
Journal ArticleDOI
Stroke and the immune system: from pathophysiology to new therapeutic strategies
Richard Macrez,Carine Ali,Olivier Toutirais,Brigitte Le Mauff,Gilles Defer,Ulrich Dirnagl,Denis Vivien +6 more
TL;DR: Development of novel and effective therapeutic strategies for stroke will require further investigation of pathways in the immune system and inflammatory responses in terms of their temporal profile (before, during, and after stroke) and risk-to-benefit therapeutic ratio of modulating them.
Journal ArticleDOI
The role of extracellular histone in organ injury
TL;DR: Drugs that block the release of histone, neutralise circulating histone or block histone signal transduction provide significant protection from mortality in animal models of acute organ injury but warrant further research to inform future clinical applications.
Journal ArticleDOI
Angiogenesis, neurogenesis and neuroplasticity in ischemic stroke.
TL;DR: These findings suggest that blood vessels play an important role as a scaffold for NPCs migration toward the damaged brain region, and the origin of newly formed vessels and the pathogenic role of neovascularization and neurogenesis are important unresolved issues in the understanding of the mechanisms after stroke.
References
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Journal ArticleDOI
Hemorrhagic transformation. The spectrum of ischemia-related brain hemorrhage.
Philip A. Teal,Michael S. Pessin +1 more
TL;DR: Hemorrhagic transformation of ischemic cerebral injury occurs commonly in embolic strokes and results from recent preliminary thrombolytic treatment trials are discussed.
Journal ArticleDOI
Hipotermia terapéutica en pacientes neurocríticos
TL;DR: The greater understanding of the pathophysiology of secondary brain damage, the go od clinical results obtained in randomized clinical trials in patients with cerebral anoxia after ventricular fibrillation and the new cooling methods that have appeared have improved the interest of hypothermia in neurocritical patients.
Journal ArticleDOI
Temporal arteritis and fever: report of a case and a clinical reanalysis of 360 cases.
TL;DR: The results showed that a case of biopsy-proven TA with typically clinical manifestation was initially misdiagnosed and that the reanalysis of 360 cases revealed that the common clinical findings at presentation were abnormal temporal arteries, headache, low fever, loss of weight, polymyalgia rheumatica, jaw clau dication, vision disorder, arthralgis or myalyias, and ear pain.
Journal Article
Statins in stroke prevention
Omer Gedikli,Merih Baykan +1 more
TL;DR: The effects of statins on stroke and the potential mechanisms of action are discussed.
Journal ArticleDOI
Correlation between plasma fibrinogen levels and white blood cell count after cerebral infarction.
TL;DR: The relationship between the two parameters suggests that the perilesional inflammatory response to the ischemic damage, expressed by leukocytosis, is directly related to the coagulative pattern of stroke.
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