Journal ArticleDOI
Pathophysiologic mechanisms of acute ischemic stroke: An overview with emphasis on therapeutic significance beyond thrombolysis
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TLDR
The objective of this review is to critically evaluate the major mechanisms underlying stroke pathophysiology, with emphasis on potential novel targets for designing newer therapeutic modalities.About:
This article is published in Pathophysiology.The article was published on 2010-06-01. It has received 492 citations till now. The article focuses on the topics: Ischemic cascade & Stroke.read more
Citations
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Journal ArticleDOI
Comparison of stroke cases with other neurological diseases on the basis of haemogram parameters
Refik Kunt,Onur Yiğitaslan +1 more
TL;DR: All neurological diseases, especially acute stroke and its types, should be examined in future prospective, randomized and controlled studies with all hemogram parameters, especially the NLR (low cost).
Journal ArticleDOI
Both ADC and rADC Average Rates in Hyperacute are Lower than those in Acute Stroke
TL;DR: The ADC and rADC average values in the hyperacute were lower than that in the acute group and there was a significant difference with p<0.05 on average ADC (10-3 mm2/s) and r ADC(%) values between thehyperacute and acute groups.
Dissertation
Epidemiologia genética do Acidente Vascular Cerebral: identificação de genes envolvidos na susceptibilidade e na recuperação do doente Dissertação
TL;DR: Dissertacao de Mestrado em Biologia Humana e Ambiente apresentada a Faculdade de Ciencias de Universidade de Lisboa, 2012.
Journal ArticleDOI
Korelasi Kadar HMGB1 dalam Serum dengan Derajat Fungsional Neurologik yang Diukur dengan NIHSS pada Pasien Stroke Trombotik Akut
TL;DR: In this article, akhir-akhir and Tujuan menunjukkan bahwa kadar HMGB1 meningkat secara signifikan pada pasien stroke dibandingkan kelompok kontrol.
Journal ArticleDOI
[Ampakines - a promising approach to neuroprotection].
TL;DR: The data obtained in recent decades indicate that AMPR is the main regulators of synaptic plasticity, learning and memory, and its restoration in various pathological processes, including reactivation of connections between neurons activated by learning in various areas of the brain.
References
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Journal ArticleDOI
Atherosclerosis — An Inflammatory Disease
TL;DR: Atherosclerosis is an inflammatory disease as discussed by the authors, and it is a major cause of death in the United States, Europe, and much of Asia, despite changes in lifestyle and use of new pharmacologic approaches to lower plasma cholesterol concentrations.
Journal ArticleDOI
Direct Proinflammatory Effect of C-Reactive Protein on Human Endothelial Cells
TL;DR: The hypothesis that CRP may play a direct role in promoting the inflammatory component of atherosclerosis and present a potential target for the treatment of Atherosclerosis is supported.
Journal ArticleDOI
p53 Has a Direct Apoptogenic Role at the Mitochondria
Motohiro Mihara,Susan Erster,Alex Zaika,Oleksi Petrenko,Thomas Chittenden,Petr Pancoska,Ute M. Moll +6 more
TL;DR: Evidence that p53 translocation to the mitochondria occurs in vivo in irradiated thymocytes is provided and it is shown that the p53 protein can directly induce permeabilization of the outer mitochondrial membrane by forming complexes with the protective BclXL and Bcl2 proteins, resulting in cytochrome c release.
Journal ArticleDOI
Glutamate-mediated astrocyte-neuron signalling.
Vladimir Parpura,Trent A. Basarsky,Fang Liu,Ksenija Jeftinija,Srdija Jeftinija,Philip G. Haydon +5 more
TL;DR: Astrocytes regulate neuronal calcium levels through the calcium-dependent release of glutamate, and an NMDA (N-methyl-d-aspartate) receptor-mediated increase in neuronal calcium is demonstrated.
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William J. Powers,Alejandro A. Rabinstein,Teri Ackerson,Opeolu Adeoye,Nicholas C. Bambakidis,Kyra J. Becker,José Biller,Michael D. Brown,Bart M. Demaerschalk,Brian L. Hoh,Edward C. Jauch,Chelsea S. Kidwell,Thabele M Leslie-Mazwi,Bruce Ovbiagele,Phillip A. Scott,Kevin N. Sheth,Andrew M. Southerland,Deborah V. Summers,David L. Tirschwell +18 more