Journal ArticleDOI
Pathophysiologic mechanisms of acute ischemic stroke: An overview with emphasis on therapeutic significance beyond thrombolysis
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TLDR
The objective of this review is to critically evaluate the major mechanisms underlying stroke pathophysiology, with emphasis on potential novel targets for designing newer therapeutic modalities.About:
This article is published in Pathophysiology.The article was published on 2010-06-01. It has received 492 citations till now. The article focuses on the topics: Ischemic cascade & Stroke.read more
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Nrf2/antioxidant defense pathway is involved in the neuroprotective effects of Sirt1 against focal cerebral ischemia in rats after hyperbaric oxygen preconditioning.
Fen Xue,Jinwen Huang,Pei-yan Ding,Hong-gang Zang,Zhi-jian Kou,Ting Li,Juan Fan,Zhengwu Peng,Wen-jun Yan +8 more
TL;DR: The results suggest that the Nrf2/antioxidant defense pathway is involved in the long lasting neuroprotective effects of Sirt1 induced by HBO-PC against transient focal cerebral ischemia.
Journal ArticleDOI
Gastrodin Alleviates Cerebral Ischemic Damage in Mice by Improving Anti-oxidant and Anti-inflammation Activities and Inhibiting Apoptosis Pathway
Zhengwu Peng,Shiquan Wang,Guanjie Chen,Min Cai,Rui Liu,Jiao Deng,Jiangzheng Liu,Tao Zhang,Qingrong Tan,Chunxu Hai +9 more
TL;DR: It was found that GAS, especially at high dose (100 mg/kg) reduced tested neuronal injury and neurobehavioral deficient in MCAO mice, and the activation of Akt/Nrf2 pathway may play a critical role in the pharmacological action of GAS.
Journal ArticleDOI
Neutrophil extracellular traps drive inflammatory pathogenesis in malaria
Sebastian Lorenz Knackstedt,Athina Georgiadou,Falko Apel,Ulrike Abu-Abed,Christopher A. Moxon,Christopher A. Moxon,Aubrey J. Cunnington,Bärbel Raupach,Deirdre Cunningham,Jean Langhorne,Renate Krüger,Valentina Barrera,Simon P. Harding,Aase Berg,Sam Patel,Kari Otterdal,Benjamin Mordmüller,Evelin Schwarzer,Volker Brinkmann,Arturo Zychlinsky,Borko Amulic,Borko Amulic +21 more
TL;DR: It is demonstrated that neutrophils have a key role in malaria immunopathology and proposed inhibition of NETs as a treatment strategy in vascular infections and shown that heme-induced NETs are essential for malaria pathogenesis.
Journal ArticleDOI
Zinc: indications in brain disorders.
TL;DR: It has been found that alterations in brain zinc status have been implicated in a wide range of neurological disorders including impaired brain development and many neurodegenerative disorders such as Alzheimer's disease, and mood disorders including depression, Parkinson's disease and Huntington's disease.
Journal ArticleDOI
Neuroprotection and antioxidants
TL;DR: Use of many modern therapeutical methods and the incorporation of several substances into the diet of patients is possible to stimulate the endogenous protective mechanisms and improve the life quality.
References
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Journal ArticleDOI
Atherosclerosis — An Inflammatory Disease
TL;DR: Atherosclerosis is an inflammatory disease as discussed by the authors, and it is a major cause of death in the United States, Europe, and much of Asia, despite changes in lifestyle and use of new pharmacologic approaches to lower plasma cholesterol concentrations.
Journal ArticleDOI
Direct Proinflammatory Effect of C-Reactive Protein on Human Endothelial Cells
TL;DR: The hypothesis that CRP may play a direct role in promoting the inflammatory component of atherosclerosis and present a potential target for the treatment of Atherosclerosis is supported.
Journal ArticleDOI
p53 Has a Direct Apoptogenic Role at the Mitochondria
Motohiro Mihara,Susan Erster,Alex Zaika,Oleksi Petrenko,Thomas Chittenden,Petr Pancoska,Ute M. Moll +6 more
TL;DR: Evidence that p53 translocation to the mitochondria occurs in vivo in irradiated thymocytes is provided and it is shown that the p53 protein can directly induce permeabilization of the outer mitochondrial membrane by forming complexes with the protective BclXL and Bcl2 proteins, resulting in cytochrome c release.
Journal ArticleDOI
Glutamate-mediated astrocyte-neuron signalling.
Vladimir Parpura,Trent A. Basarsky,Fang Liu,Ksenija Jeftinija,Srdija Jeftinija,Philip G. Haydon +5 more
TL;DR: Astrocytes regulate neuronal calcium levels through the calcium-dependent release of glutamate, and an NMDA (N-methyl-d-aspartate) receptor-mediated increase in neuronal calcium is demonstrated.
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