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Open AccessJournal Article

Photoacoustic imaging in biomedicine

Xu Xiao
- 01 Jan 2008 - 
TLDR
In this paper, the authors provide an overview of the rapidly developing field of photoacoustic imaging, which is a promising method for visualizing biological tissues with optical absorbers, compared with optical imaging and ultrasonic imaging.
Abstract
Photoacoustic imaging is a promising method for visualizing biological tissues with optical absorbers. This article provides an overview of the rapidly developing field of photoacoustic imaging. Photoacoustics, the physical basis of photoacoustic imaging, is analyzed briefly. The merits of photoacoustic technology, compared with optical imaging and ultrasonic imaging, are described. Various imaging techniques are also discussed, including scanning tomography, computed tomography and original detection of photoacoustic imaging. Finally, some biomedical applications of photoacoustic imaging are summarized.

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Citations
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Biomedical photoacoustic imaging

TL;DR: The underlying physical principles of the technique, its practical implementation, and a range of clinical and preclinical applications are reviewed.
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Multiscale photoacoustic microscopy and computed tomography.

TL;DR: PAT holds the promise of in vivo imaging at multiple length scales ranging from subcellular organelles to organs with the same contrast origin, an important application in multiscale systems biology research.
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Porphysome nanovesicles generated by porphyrin bilayers for use as multimodal biophotonic contrast agents

TL;DR: The development of porphysomes; nanovesicles formed from self-assembled porphyrin bilayers that generated large, tunable extinction coefficients, structure-dependent fluorescence self-quenching and unique photothermal and photoacoustic properties demonstrate the multimodal potential of organic nanoparticles for biophotonic imaging and therapy.
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Tutorial on Photoacoustic Microscopy and Computed Tomography

TL;DR: In this paper, the fundamentals of photoacoustics are first introduced and then, scanning photoacoustic microscopy and reconstruction-based photo-acoustic computed tomography (or photo acoustics computed tomograph) are covered.
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Development and Applications of Photo-triggered Theranostic Agents

TL;DR: Recent developments in the use of light-triggered theranostic agents for simultaneous imaging and photoactivation of therapeutic agents for several diseases are reviewed.
References
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Journal ArticleDOI

Forward-viewing photoacoustic imaging probe with bundled ultra-thin hollow optical fibers

TL;DR: In this paper, a photoacoustic imaging system composed of a flexible bundle of thin hollow-optical fibers was proposed for endoscopic diagnosis, where the hollow fibers in the bundle were aligned at the input end, so the hollow fiber was sequentially excited by linearly scanning the laser beam at the output end.
Proceedings ArticleDOI

Photoacoustic Imaging With Integrating Line Detectors

TL;DR: In this article, a line detector is proposed to integrate the pressure along one dimension whereby the 3D problem is reduced to a 2D problem and enables a tomography setup that requires only a single axis of rotation.
Proceedings ArticleDOI

Signal processing for photoacoustic tomography

TL;DR: This study examines one of the open problems yet to solve in photoacoustic tomography and provides some advancement in signal processing for dealing the projection issue while considering different perspectives in the interpretation of the transport model to be applied in a broader manner.
Proceedings ArticleDOI

Simulation of photoacoustic tomography (PAT) system in COMSOL and comparison of two popular reconstruction techniques

TL;DR: This study attempts to describe how a commercially available Finite Element software (COMSOL(R), can serve as a single platform for simulating PAT that couples the electromagnetic, thermodynamic and acoustic pressure physics involved in PA phenomena.
Proceedings ArticleDOI

Dynamic manipulation of magnetic contrast agents in photoacoustic imaging

TL;DR: In this paper, a coupled nanoparticle combining a superparamagnetic core with a thin, isolated gold shell providing strong absorption in the near infrared can be used for magnetomotive photoacoustic imaging (mmPA), a new technique in which magnetic manipulation of the particle during PA imaging greatly enhances molecular contrast specificity.
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