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Open AccessJournal Article

Photoacoustic imaging in biomedicine

Xu Xiao
- 01 Jan 2008 - 
TLDR
In this paper, the authors provide an overview of the rapidly developing field of photoacoustic imaging, which is a promising method for visualizing biological tissues with optical absorbers, compared with optical imaging and ultrasonic imaging.
Abstract
Photoacoustic imaging is a promising method for visualizing biological tissues with optical absorbers. This article provides an overview of the rapidly developing field of photoacoustic imaging. Photoacoustics, the physical basis of photoacoustic imaging, is analyzed briefly. The merits of photoacoustic technology, compared with optical imaging and ultrasonic imaging, are described. Various imaging techniques are also discussed, including scanning tomography, computed tomography and original detection of photoacoustic imaging. Finally, some biomedical applications of photoacoustic imaging are summarized.

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Citations
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Biomedical photoacoustic imaging

TL;DR: The underlying physical principles of the technique, its practical implementation, and a range of clinical and preclinical applications are reviewed.
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Multiscale photoacoustic microscopy and computed tomography.

TL;DR: PAT holds the promise of in vivo imaging at multiple length scales ranging from subcellular organelles to organs with the same contrast origin, an important application in multiscale systems biology research.
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Porphysome nanovesicles generated by porphyrin bilayers for use as multimodal biophotonic contrast agents

TL;DR: The development of porphysomes; nanovesicles formed from self-assembled porphyrin bilayers that generated large, tunable extinction coefficients, structure-dependent fluorescence self-quenching and unique photothermal and photoacoustic properties demonstrate the multimodal potential of organic nanoparticles for biophotonic imaging and therapy.
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Tutorial on Photoacoustic Microscopy and Computed Tomography

TL;DR: In this paper, the fundamentals of photoacoustics are first introduced and then, scanning photoacoustic microscopy and reconstruction-based photo-acoustic computed tomography (or photo acoustics computed tomograph) are covered.
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Development and Applications of Photo-triggered Theranostic Agents

TL;DR: Recent developments in the use of light-triggered theranostic agents for simultaneous imaging and photoactivation of therapeutic agents for several diseases are reviewed.
References
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Proceedings ArticleDOI

Development of waveguide sensors for the application in photoacoustic tomography

TL;DR: In this paper, the authors used a planar waveguide (PWG) and a common path polarization interferometer (CPPI) to detect acoustic signals in a photoacoustic tomography (PAT) system.
Proceedings ArticleDOI

Operating point stabilization of fiber-based line detectors for photoacoustic imaging

TL;DR: In this article, an alternative stabilization method, the change of the optical path length, is presented by stretching the fiber with piezoelectric tubes, which is used to acquire broad-band ultrasonic signals.
Proceedings ArticleDOI

Frequency analysis of optoacoustic signals in laser heated tissues

TL;DR: In this paper, porcine tenderloin samples were heated using a 1000 μm core optical fiber coupled to an 810 nm diode laser at a constant power of 7 W for 10 minutes.
Proceedings ArticleDOI

A practical optical-resolution photoacoustic microscopy prototype using a 300 mW visible laser diode

TL;DR: In this article, a visible laser-diode-based optical-resolution photoacoustic microscopy (LD-OR-PAM) is presented for vasculature imaging, which has the desirable properties of being portable, low-cost, and label-free.
Proceedings ArticleDOI

Image reconstruction in quantitative photoacoustic tomography using the radiative transfer equation and the diffusion approximation

TL;DR: In this paper, a reconstruction of absorption and scattering distributions using the radiative transfer equation and the diffusion approximation as forward models for light propagation is investigated, and the results show that the diffusion approximation can produce as good estimates for absorption as the RTE.
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