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Open AccessJournal Article

Photoacoustic imaging in biomedicine

Xu Xiao
- 01 Jan 2008 - 
TLDR
In this paper, the authors provide an overview of the rapidly developing field of photoacoustic imaging, which is a promising method for visualizing biological tissues with optical absorbers, compared with optical imaging and ultrasonic imaging.
Abstract
Photoacoustic imaging is a promising method for visualizing biological tissues with optical absorbers. This article provides an overview of the rapidly developing field of photoacoustic imaging. Photoacoustics, the physical basis of photoacoustic imaging, is analyzed briefly. The merits of photoacoustic technology, compared with optical imaging and ultrasonic imaging, are described. Various imaging techniques are also discussed, including scanning tomography, computed tomography and original detection of photoacoustic imaging. Finally, some biomedical applications of photoacoustic imaging are summarized.

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Citations
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Time reversal method with stabilizing boundary conditions for Photoacoustic tomography

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Curve-Driven-Based Acoustic Inversion for Photoacoustic Tomography

TL;DR: A novel method, named as the curve-driven-based model-matrix inversion (CDMMI), to calculate the model matrix for tomographic reconstruction in photoacoustic imaging is presented, which eliminated the use of interpolation techniques, and thus avoided all interpolation related errors.
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In vivo determination of acute myocardial ischemia based on photoacoustic imaging with a focused transducer

TL;DR: The preliminary results show that the photoacoustic signal could identify the myocardium and imply that the intensity and area of photoac acoustic images are the rapid fall of an exponential model with an increase of delaying time after the left anterior descending coronary artery occlusion.
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Enhanced sensitivity carbon nanotubes as targeted photoacoustic molecular imaging agents

TL;DR: This work lays the foundations for future in-vivo studies that will use the SWNT-ICG particles as imaging agents administered systemically, and shows great promise for high sensitivity photoacoustic imaging of molecular targets in- vivo.
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Evaluation of High Frequency Piezoelectric Micromachined Ultrasound Transducers for Photoacoustic Imaging

TL;DR: B-mode images reconstructed from A-lines recorded during the linear scanning of a single element clearly imaged all the targets, thus validating the potential of the fabricated PMUTs for photoacoustic imaging.
References
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Journal ArticleDOI

Biomedical photoacoustic imaging

TL;DR: The underlying physical principles of the technique, its practical implementation, and a range of clinical and preclinical applications are reviewed.
Journal ArticleDOI

Multiscale photoacoustic microscopy and computed tomography.

TL;DR: PAT holds the promise of in vivo imaging at multiple length scales ranging from subcellular organelles to organs with the same contrast origin, an important application in multiscale systems biology research.
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Porphysome nanovesicles generated by porphyrin bilayers for use as multimodal biophotonic contrast agents

TL;DR: The development of porphysomes; nanovesicles formed from self-assembled porphyrin bilayers that generated large, tunable extinction coefficients, structure-dependent fluorescence self-quenching and unique photothermal and photoacoustic properties demonstrate the multimodal potential of organic nanoparticles for biophotonic imaging and therapy.
Journal ArticleDOI

Tutorial on Photoacoustic Microscopy and Computed Tomography

TL;DR: In this paper, the fundamentals of photoacoustics are first introduced and then, scanning photoacoustic microscopy and reconstruction-based photo-acoustic computed tomography (or photo acoustics computed tomograph) are covered.
Journal ArticleDOI

Development and Applications of Photo-triggered Theranostic Agents

TL;DR: Recent developments in the use of light-triggered theranostic agents for simultaneous imaging and photoactivation of therapeutic agents for several diseases are reviewed.
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