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Open AccessJournal Article

Photoacoustic imaging in biomedicine

Xu Xiao
- 01 Jan 2008 - 
TLDR
In this paper, the authors provide an overview of the rapidly developing field of photoacoustic imaging, which is a promising method for visualizing biological tissues with optical absorbers, compared with optical imaging and ultrasonic imaging.
Abstract
Photoacoustic imaging is a promising method for visualizing biological tissues with optical absorbers. This article provides an overview of the rapidly developing field of photoacoustic imaging. Photoacoustics, the physical basis of photoacoustic imaging, is analyzed briefly. The merits of photoacoustic technology, compared with optical imaging and ultrasonic imaging, are described. Various imaging techniques are also discussed, including scanning tomography, computed tomography and original detection of photoacoustic imaging. Finally, some biomedical applications of photoacoustic imaging are summarized.

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Citations
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Efficient discrete cosine transform model-based algorithm for photoacoustic image reconstruction

TL;DR: It would be concluded that the model-based PAI reconstruction can be accelerated by using the proposed algorithm, so that the practical applicability of PAI may be enhanced.
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Y-Net: A Hybrid Deep Learning Reconstruction Framework for Photoacoustic Imaging in vivo.

TL;DR: This paper presents a non-iterative scheme filling the gap between existing direct-processing and post-processing methods, and proposes a new framework Y-Net: a CNN architecture to reconstruct the PA image by optimizing both raw data and beamformed images once.
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Tumor homing indocyanine green encapsulated micelles for near infrared and photoacoustic imaging of tumors

TL;DR: This study developed indocyanine green (ICG)-encapsulated micelles specific for the CD 44 receptor and used in near infrared and photoacoustic imaging of tumors and encourages the application of this HA-ICG-based nano-platform as a tumor-specific contrast agent for PAI.

Molecular specific photoacoustic imaging using plasmonic gold nanoparticles

TL;DR: In this article, the authors used tissue models to evaluate the sensitivity of molecular specific photo-acoustic imaging in detecting cancer cells labeled with EGFR-targeted gold nanoparticles, and the results of their study indicate that highly sensitive detection of cancer cells is feasible using photoacoustical imaging and plasmonic gold nano-articles.
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Thermal diffusivity imaging with the thermal lens microscope.

TL;DR: A coaxial thermal lens microscope was used to generate images based on both the absorbance and thermal diffusivity of histological samples, using an acousto-optic modulator to modulate the amplitude and phase of the lock-in amplifier's signal.
References
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Journal ArticleDOI

Biomedical photoacoustic imaging

TL;DR: The underlying physical principles of the technique, its practical implementation, and a range of clinical and preclinical applications are reviewed.
Journal ArticleDOI

Multiscale photoacoustic microscopy and computed tomography.

TL;DR: PAT holds the promise of in vivo imaging at multiple length scales ranging from subcellular organelles to organs with the same contrast origin, an important application in multiscale systems biology research.
Journal ArticleDOI

Porphysome nanovesicles generated by porphyrin bilayers for use as multimodal biophotonic contrast agents

TL;DR: The development of porphysomes; nanovesicles formed from self-assembled porphyrin bilayers that generated large, tunable extinction coefficients, structure-dependent fluorescence self-quenching and unique photothermal and photoacoustic properties demonstrate the multimodal potential of organic nanoparticles for biophotonic imaging and therapy.
Journal ArticleDOI

Tutorial on Photoacoustic Microscopy and Computed Tomography

TL;DR: In this paper, the fundamentals of photoacoustics are first introduced and then, scanning photoacoustic microscopy and reconstruction-based photo-acoustic computed tomography (or photo acoustics computed tomograph) are covered.
Journal ArticleDOI

Development and Applications of Photo-triggered Theranostic Agents

TL;DR: Recent developments in the use of light-triggered theranostic agents for simultaneous imaging and photoactivation of therapeutic agents for several diseases are reviewed.
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