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Open AccessJournal Article

Photoacoustic imaging in biomedicine

Xu Xiao
- 01 Jan 2008 - 
TLDR
In this paper, the authors provide an overview of the rapidly developing field of photoacoustic imaging, which is a promising method for visualizing biological tissues with optical absorbers, compared with optical imaging and ultrasonic imaging.
Abstract
Photoacoustic imaging is a promising method for visualizing biological tissues with optical absorbers. This article provides an overview of the rapidly developing field of photoacoustic imaging. Photoacoustics, the physical basis of photoacoustic imaging, is analyzed briefly. The merits of photoacoustic technology, compared with optical imaging and ultrasonic imaging, are described. Various imaging techniques are also discussed, including scanning tomography, computed tomography and original detection of photoacoustic imaging. Finally, some biomedical applications of photoacoustic imaging are summarized.

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Citations
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Simultaneous multispectral coded excitation for photoacoustic imaging

TL;DR: The coded excitation method to separate multispectral components, which are irradiated with coded laser pulses from different laser sources, into separate spectral components is investigated and it is found that the proposed method can reduce the sending time cost for mult ispectral information.
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Submillimeter Magnetic Microrobot Tracking Using an Integrated Ultrasound and Photoacoustic Imaging System

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Monitoring of the excretion of fluorescent nanocomposites out of the body using artificial neural networks

TL;DR: In this article, an approach to monitoring the removal of luminescent nanocomposites and their components with urine using artificial neural networks is proposed, which is applicable for optical imaging of any fluorescent nanoparticles used as imaging nanoagents in biological tissue.
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Frequency domain non-contact photoacoustic microscopy

TL;DR: In this paper, a non-contact Fd-PAM was proposed, in which photoacoustic signal is generated by an amplitude modulated continuous-wave (CW) laser and detected at the sample surface using two wave mixing (interferometer) in a photorefractive crystal (PRC).
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Clinical demonstration of epi-mode photoacoustic clutter reduction using palpation scanning

TL;DR: This method has now for the first time been applied to free-hand real-time clinical scans, and significant contrast improvement of clinical PA images was demonstrated.
References
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Biomedical photoacoustic imaging

TL;DR: The underlying physical principles of the technique, its practical implementation, and a range of clinical and preclinical applications are reviewed.
Journal ArticleDOI

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TL;DR: PAT holds the promise of in vivo imaging at multiple length scales ranging from subcellular organelles to organs with the same contrast origin, an important application in multiscale systems biology research.
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Porphysome nanovesicles generated by porphyrin bilayers for use as multimodal biophotonic contrast agents

TL;DR: The development of porphysomes; nanovesicles formed from self-assembled porphyrin bilayers that generated large, tunable extinction coefficients, structure-dependent fluorescence self-quenching and unique photothermal and photoacoustic properties demonstrate the multimodal potential of organic nanoparticles for biophotonic imaging and therapy.
Journal ArticleDOI

Tutorial on Photoacoustic Microscopy and Computed Tomography

TL;DR: In this paper, the fundamentals of photoacoustics are first introduced and then, scanning photoacoustic microscopy and reconstruction-based photo-acoustic computed tomography (or photo acoustics computed tomograph) are covered.
Journal ArticleDOI

Development and Applications of Photo-triggered Theranostic Agents

TL;DR: Recent developments in the use of light-triggered theranostic agents for simultaneous imaging and photoactivation of therapeutic agents for several diseases are reviewed.
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