Open AccessJournal Article
Photoacoustic imaging in biomedicine
TLDR
In this paper, the authors provide an overview of the rapidly developing field of photoacoustic imaging, which is a promising method for visualizing biological tissues with optical absorbers, compared with optical imaging and ultrasonic imaging.Abstract:
Photoacoustic imaging is a promising method for visualizing biological tissues with optical absorbers. This article provides an overview of the rapidly developing field of photoacoustic imaging. Photoacoustics, the physical basis of photoacoustic imaging, is analyzed briefly. The merits of photoacoustic technology, compared with optical imaging and ultrasonic imaging, are described. Various imaging techniques are also discussed, including scanning tomography, computed tomography and original detection of photoacoustic imaging. Finally, some biomedical applications of photoacoustic imaging are summarized.read more
Citations
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Biomedical photoacoustic imaging
TL;DR: The underlying physical principles of the technique, its practical implementation, and a range of clinical and preclinical applications are reviewed.
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Multiscale photoacoustic microscopy and computed tomography.
TL;DR: PAT holds the promise of in vivo imaging at multiple length scales ranging from subcellular organelles to organs with the same contrast origin, an important application in multiscale systems biology research.
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Porphysome nanovesicles generated by porphyrin bilayers for use as multimodal biophotonic contrast agents
Jonathan F. Lovell,Cheng S. Jin,Cheng S. Jin,Elizabeth Huynh,Elizabeth Huynh,Honglin Jin,Honglin Jin,Chulhong Kim,John L. Rubinstein,Warren C. W. Chan,Weiguo Cao,Lihong V. Wang,Gang Zheng,Gang Zheng +13 more
TL;DR: The development of porphysomes; nanovesicles formed from self-assembled porphyrin bilayers that generated large, tunable extinction coefficients, structure-dependent fluorescence self-quenching and unique photothermal and photoacoustic properties demonstrate the multimodal potential of organic nanoparticles for biophotonic imaging and therapy.
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Tutorial on Photoacoustic Microscopy and Computed Tomography
TL;DR: In this paper, the fundamentals of photoacoustics are first introduced and then, scanning photoacoustic microscopy and reconstruction-based photo-acoustic computed tomography (or photo acoustics computed tomograph) are covered.
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Development and Applications of Photo-triggered Theranostic Agents
Prakash Rai,Srivalleesha Mallidi,Xiang Zheng,Ramtin Rahmanzadeh,Youssef Mir,Stefan A. Elrington,Ahmat Khurshid,Ahmat Khurshid,Tayyaba Hasan,Tayyaba Hasan +9 more
TL;DR: Recent developments in the use of light-triggered theranostic agents for simultaneous imaging and photoactivation of therapeutic agents for several diseases are reviewed.
References
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Bayesian Image Reconstruction in Quantitative Photoacoustic Tomography
TL;DR: The noise of optical data is modelled as Gaussian distributed with mean and covariance approximated by solving several acoustic inverse initial value problems using acoustic noise samples as data and Bayesian approximation error modelling is applied to compensate for the modelling errors in the optical data caused by the acoustic solver.
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Leng-Chun Chen,Chen-Wei Wei,Jeffrey S. Souris,Shih-Hsun Cheng,Chin-Tu Chen,Chung-Shi Yang,Pai-Chi Li,Leu-Wei Lo +7 more
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Chronic label-free volumetric photoacoustic microscopy of melanoma cells in three-dimensional porous scaffolds
TL;DR: In this article, the spatial distribution and temporal proliferation of cells inside 3D porous scaffolds with thicknesses over 1 mm were investigated using photoacoustic microscopy (PAM) images, and the number of cells in the scaffold was quantitatively measured from the as-obtained volumetric information.
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A brief account of nanoparticle contrast agents for photoacoustic imaging.
TL;DR: The potential of exogenous nanoparticle-based agents for PAI applications including contrast based on gold particles, carbon nanotubes, and encapsulated copper compounds are summarized.
Journal ArticleDOI
Ultrasound-array-based real-time photoacoustic microscopy of human pulsatile dynamics in vivo
TL;DR: The UA-PAM system, capable of real-time B-scan imaging at 50 Hz and high-speed 3-D imaging, is validated by imaging the subcutaneous microvasculature in rats and humans and demonstrates the feasibility of noninvasive in vivo imaging of human pulsatile dynamics.
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