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Open AccessJournal Article

Photoacoustic imaging in biomedicine

Xu Xiao
- 01 Jan 2008 - 
TLDR
In this paper, the authors provide an overview of the rapidly developing field of photoacoustic imaging, which is a promising method for visualizing biological tissues with optical absorbers, compared with optical imaging and ultrasonic imaging.
Abstract
Photoacoustic imaging is a promising method for visualizing biological tissues with optical absorbers. This article provides an overview of the rapidly developing field of photoacoustic imaging. Photoacoustics, the physical basis of photoacoustic imaging, is analyzed briefly. The merits of photoacoustic technology, compared with optical imaging and ultrasonic imaging, are described. Various imaging techniques are also discussed, including scanning tomography, computed tomography and original detection of photoacoustic imaging. Finally, some biomedical applications of photoacoustic imaging are summarized.

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Citations
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Biomedical photoacoustic imaging

TL;DR: The underlying physical principles of the technique, its practical implementation, and a range of clinical and preclinical applications are reviewed.
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Multiscale photoacoustic microscopy and computed tomography.

TL;DR: PAT holds the promise of in vivo imaging at multiple length scales ranging from subcellular organelles to organs with the same contrast origin, an important application in multiscale systems biology research.
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Porphysome nanovesicles generated by porphyrin bilayers for use as multimodal biophotonic contrast agents

TL;DR: The development of porphysomes; nanovesicles formed from self-assembled porphyrin bilayers that generated large, tunable extinction coefficients, structure-dependent fluorescence self-quenching and unique photothermal and photoacoustic properties demonstrate the multimodal potential of organic nanoparticles for biophotonic imaging and therapy.
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Tutorial on Photoacoustic Microscopy and Computed Tomography

TL;DR: In this paper, the fundamentals of photoacoustics are first introduced and then, scanning photoacoustic microscopy and reconstruction-based photo-acoustic computed tomography (or photo acoustics computed tomograph) are covered.
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Development and Applications of Photo-triggered Theranostic Agents

TL;DR: Recent developments in the use of light-triggered theranostic agents for simultaneous imaging and photoactivation of therapeutic agents for several diseases are reviewed.
References
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Narrow Absorption NIR Wavelength Organic Nanoparticles Enable Multiplexed Photoacoustic Imaging.

TL;DR: The block copolymer directed self-assembly process, Flash NanoPrecipitation (FNP), is used to form series of highly hydrophobic optical dyes into stable, biocompatible, and water-dispersible nanoparticles (NPs) with sizes from 38 to 88 nm and with polyethylene glycol surface coatings suitable for in vivo use.
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Fast and High-Resolution Three-Dimensional Hybrid-Domain Photoacoustic Imaging Incorporating Analytical-Focused Transducer Beam Amplitude

TL;DR: A 3-D ARPAM imaging reconstruction method with high precision, high efficiency, and low memory cost is proposed that inherits the framework of model-based reconstructions and incorporates the forward acoustic model in the hybrid domain.
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Integration of photoacoustic imaging and high-intensity focused ultrasound

TL;DR: The results demonstrated that PAI technology may potentially be integrated with HIFU ablation for image-guided therapy, as well as ensuring the correct alignment between the therapeutic beam and the planned treatment volume.
Journal ArticleDOI

Photoacoustic tomography of carrageenan-induced arthritis in a rat model.

TL;DR: PAT has the potential for highly sensitive diagnosis and evaluation of pathologic hallmarks of acute inflammatory arthritis, and Anatomical correlation with histological sections of imaged joints and microMRI results verified the findings of PAT.
Journal ArticleDOI

Multi-Wavelength Photoacoustic Visualization of High Intensity Focused Ultrasound Lesions

TL;DR: It is suggested that multi-wavelength PA imaging has potential to obtain accurate characterization of HifU lesion extent and may be better suited to guide HIFU ablation therapies during clinical treatments than single-wa wavelength methods.
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