Open AccessJournal Article
Photoacoustic imaging in biomedicine
TLDR
In this paper, the authors provide an overview of the rapidly developing field of photoacoustic imaging, which is a promising method for visualizing biological tissues with optical absorbers, compared with optical imaging and ultrasonic imaging.Abstract:
Photoacoustic imaging is a promising method for visualizing biological tissues with optical absorbers. This article provides an overview of the rapidly developing field of photoacoustic imaging. Photoacoustics, the physical basis of photoacoustic imaging, is analyzed briefly. The merits of photoacoustic technology, compared with optical imaging and ultrasonic imaging, are described. Various imaging techniques are also discussed, including scanning tomography, computed tomography and original detection of photoacoustic imaging. Finally, some biomedical applications of photoacoustic imaging are summarized.read more
Citations
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Biomedical photoacoustic imaging
TL;DR: The underlying physical principles of the technique, its practical implementation, and a range of clinical and preclinical applications are reviewed.
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Multiscale photoacoustic microscopy and computed tomography.
TL;DR: PAT holds the promise of in vivo imaging at multiple length scales ranging from subcellular organelles to organs with the same contrast origin, an important application in multiscale systems biology research.
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Porphysome nanovesicles generated by porphyrin bilayers for use as multimodal biophotonic contrast agents
Jonathan F. Lovell,Cheng S. Jin,Cheng S. Jin,Elizabeth Huynh,Elizabeth Huynh,Honglin Jin,Honglin Jin,Chulhong Kim,John L. Rubinstein,Warren C. W. Chan,Weiguo Cao,Lihong V. Wang,Gang Zheng,Gang Zheng +13 more
TL;DR: The development of porphysomes; nanovesicles formed from self-assembled porphyrin bilayers that generated large, tunable extinction coefficients, structure-dependent fluorescence self-quenching and unique photothermal and photoacoustic properties demonstrate the multimodal potential of organic nanoparticles for biophotonic imaging and therapy.
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Tutorial on Photoacoustic Microscopy and Computed Tomography
TL;DR: In this paper, the fundamentals of photoacoustics are first introduced and then, scanning photoacoustic microscopy and reconstruction-based photo-acoustic computed tomography (or photo acoustics computed tomograph) are covered.
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Development and Applications of Photo-triggered Theranostic Agents
Prakash Rai,Srivalleesha Mallidi,Xiang Zheng,Ramtin Rahmanzadeh,Youssef Mir,Stefan A. Elrington,Ahmat Khurshid,Ahmat Khurshid,Tayyaba Hasan,Tayyaba Hasan +9 more
TL;DR: Recent developments in the use of light-triggered theranostic agents for simultaneous imaging and photoactivation of therapeutic agents for several diseases are reviewed.
References
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Journal ArticleDOI
Photoacoustic Imaging of Mesenchymal Stem Cells in Living Mice via Silica-Coated Gold Nanorods
TL;DR: In this paper, the use of silica-coated gold nanorods as a contrast agent for photoacoustic imaging and quantitation of mesenchymal stem cells in rodent muscle tissue was reported.
Journal ArticleDOI
Photoacoustic imaging of living mouse brain vasculature using hollow gold nanospheres
Wei Lu,Qian Huang,Geng Ku,Xiaoxia Wen,Min Zhou,Dmitry V. Guzatov,Peter Brecht,Richard Su,Alexander A. Oraevsky,Lihong V. Wang,Chun Li +10 more
TL;DR: It is indicated that PEG-HAuNS are promising contrast agents for PAT, with high spatial resolution and enhanced sensitivity, and preliminary results showed no acute toxicity to the liver, spleen, or kidneys in mice following a single imaging dose.
Journal ArticleDOI
In vivo, Noninvasive, Label-Free Detection and Eradication of Circulating Metastatic Melanoma Cells Using Two-Color Photoacoustic Flow Cytometry with a Diode Laser
TL;DR: Advances in in vivo photoacoustic blood cancer testing with a high-pulse-repetition-rate diode laser make feasible the early diagnosis of melanoma during the initial parallel progression of primary tumor and CTCs, and laser blood purging using noninvasive or hemodialysis-like schematics for the prevention of metastasis.
Journal ArticleDOI
Nanoparticles for photoacoustic imaging
TL;DR: The design and application of each nanoparticle-based contrast agent in relation to the field of PAI are detailed and particular focus is given to nanoparticles whose absorption mechanism is based on surface plasmon resonance.
Journal ArticleDOI
Thermoacoustic tomography with variable sound speed
Plamen Stefanov,Gunther Uhlmann +1 more
TL;DR: In this paper, the mathematical model of thermoacoustic tomography in media with a variable speed for a fixed time interval, greater than the diameter of the domain, was studied and necessary and sufficient conditions for uniqueness and stability when the measurements are taken on a part of the boundary.
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