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Open AccessJournal ArticleDOI

The determination of ascorbic acid in whole blood and urine through the 2,4-dinitrophenylhydrazine derivative of dehydroascorbic acid

Joseph H. Roe, +1 more
- 01 Feb 1943 - 
- Vol. 147, Iss: 2, pp 399-407
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This article is published in Journal of Biological Chemistry.The article was published on 1943-02-01 and is currently open access. It has received 1689 citations till now. The article focuses on the topics: Ascorbic acid & Dehydroascorbic acid.

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Journal ArticleDOI

The effect of chronic hypovitaminosis C on the metabolism of cholesterol and atherogenesis in guinea pigs

TL;DR: High doses of vitamin C did not prevent the appearance of morphological changes in vascular system but only slowed down the process of atheromatous reconstruction; with decreasing saturation of tissues with vitamin C, the accumulation of cholesterol in the relevant tissue was increasing.
Journal ArticleDOI

The Role of Ascorbate in Biomembrane Energetics

TL;DR: The results are consistent with a role of the ascorbate free radical as an acceptor for electron transport-mediated transfer of electrons from NADH perhaps to oxygen by coated membranes as a part of a mechanism to drive membrane translocations via generation of a proton gradient or of a membrane potential.
Journal ArticleDOI

Serum Ascorbic Acid in Patients Undergoing Chronic Hemodialysis

TL;DR: The mean blood pH value, measured in 24 patients on chronic hemodialysis, showed a significant, though slight, decrease during supplementation with 500 mg daily as compared with the mean presupplementation value, but no statistically significant changes were observed in blood bicarbonate, base excess or PCO2 values.
Book ChapterDOI

Ascorbic Acid and the Immune Response

TL;DR: The role of ascorbic acid in the immune response is reviewed here with regard to cellular and humoral functions, and experiments pertaining to the role in autoimmunity and anaphylaxis are discussed.
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