The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood-brain barrier.
Tetyana P. Buzhdygan,Brandon J. DeOre,Abigail Baldwin-Leclair,Trent A. Bullock,Hannah McGary,Jana A. Khan,Roshanak Razmpour,Jonathan F. Hale,Peter A. Galie,Raghava Potula,Allison M. Andrews,Servio H. Ramirez +11 more
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TLDR
Together, these results are the first to show the direct impact that the SARS-CoV-2 spike protein could have on brain endothelial cells; thereby offering a plausible explanation for the neurological consequences seen in COVID-19 patients.About:
This article is published in Neurobiology of Disease.The article was published on 2020-10-11 and is currently open access. It has received 302 citations till now. The article focuses on the topics: Blood–brain barrier & Neuroinflammation.read more
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Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome.
Kerri L. LaRovere,Becky J. Riggs,Tina Young Poussaint,Cameron C. Young,Margaret M Newhams,Mia Maamari,Tracie C. Walker,Aalok R. Singh,Heda Dapul,Charlotte V. Hobbs,Gwenn E. McLaughlin,Mary Beth F. Son,Aline B Maddux,Katharine N. Clouser,Courtney M. Rowan,John K. McGuire,Julie C. Fitzgerald,Shira J. Gertz,Steven L. Shein,Alvaro Coronado Munoz,Neal J. Thomas,Katherine Irby,Emily R Levy,Mary A. Staat,Mark W Tenforde,Leora R. Feldstein,Natasha B. Halasa,John S. Giuliano,Mark W. Hall,Michele Kong,Christopher L. Carroll,Jennifer E. Schuster,Sule Doymaz,Laura Loftis,Keiko M. Tarquinio,Christopher Babbitt,Ryan Nofziger,Lawrence C. Kleinman,Michael A. Keenaghan,Natalie Z. Cvijanovich,Philip C. Spinella,Janet R. Hume,Kari Wellnitz,Elizabeth H. Mack,Kelly Michelson,Heidi R. Flori,Manish M. Patel,Adrienne G. Randolph +47 more
TL;DR: In this article, the authors investigated the range and severity of neurologic involvement among children and adolescents associated with COVID-19 and found that patients with involvement were more likely to have underlying neurologic disorders (81 of 365 [22] compared with those without (113 of 1330 [8%]), but a similar number were previously healthy (195 [53%] vs 723 [54%]) and met criteria for multisystem inflammatory syndrome in children (126 [35%] vs 490 [37%]).
Journal ArticleDOI
Mid and long-term neurological and neuropsychiatric manifestations of post-COVID-19 syndrome: A meta-analysis
Lavien Premraj,Nivedha V. Kannapadi,Jackie Briggs,Stella M. Seal,Denise Battaglini,Jonathon P. Fanning,Jacky Y. Suen,Chiara Robba,John F. Fraser,Sung Min Cho +9 more
TL;DR: In this article , a systematic search of 1458 articles, 18 studies, encompassing a total of 10,530 patients, were analyzed to determine the prevalence of neurological and neuropsychiatric symptoms reported 12 weeks (3 months) or more after acute COVID-19 onset in adults.
Journal ArticleDOI
SARS-CoV-2 crosses the blood-brain barrier accompanied with basement membrane disruption without tight junctions alteration.
Ling Zhang,Li Zhou,Linlin Bao,Jiangning Liu,Hua Zhu,Qi Lv,Ruixue Liu,Wei Chen,Wei Tong,Qiang Wei,Yanfeng Xu,Wei Deng,Hong Gao,Jing Xue,Zhiqi Song,Pin Yu,Yunlin Han,Yu Zhang,Xiuping Sun,Xuan Yu,Chuan Qin +20 more
TL;DR: In this paper, SARS-CoV-2 was found to cross the BBB in a transcellular pathway accompanied with basement membrane disrupted without obvious alteration of tight junctions (TJs).
Journal ArticleDOI
Neuropathobiology of COVID-19: The Role for Glia
Marie-Ève Tremblay,Charlotte Madore,Maude Bordeleau,Maude Bordeleau,Li Tian,Alexei Verkhratsky,Alexei Verkhratsky,Alexei Verkhratsky +7 more
TL;DR: The neurotropism of SARS-CoV-2, the implication of neuroinflammation, adaptive and innate immunity, autoimmunity, as well as astrocytic and microglial immune and homeostatic functions in the neurological and psychiatric aspects of COVID-19 are discussed.
Journal ArticleDOI
The chronic neuropsychiatric sequelae of COVID-19: The need for a prospective study of viral impact on brain functioning.
Gabriel A. de Erausquin,Heather M. Snyder,Maria C. Carrillo,Akram A. Hosseini,Traolach S. Brugha,Sudha Seshadri +5 more
TL;DR: The Alzheimer's Association and representatives from more than 30 countries have formed an international consortium to study the short and long-term consequences of SARS-CoV-2 on the central nervous system (CNS) including the underlying biology that may contribute to AD and other dementias as discussed by the authors.
References
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Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.
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TL;DR: The findings are consistent with person-to-person transmission of this novel coronavirus in hospital and family settings, and the reports of infected travellers in other geographical regions.
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The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2
Alexander E. Gorbalenya,Susan C. Baker,Ralph S. Baric,Raoul J. de Groot,Christian Drosten,Anastasia A. Gulyaeva,Bart L. Haagmans,Chris Lauber,Andrey M. Leontovich,Benjamin W. Neuman,Dmitry Penzar,Stanley Perlman,Leo L.M. Poon,Dmitry V. Samborskiy,Igor A. Sidorov,Isabel Sola,John Ziebuhr +16 more
TL;DR: The independent zoonotic transmission of SARS-CoV and SARS -CoV-2 highlights the need for studying viruses at the species level to complement research focused on individual pathogenic viruses of immediate significance.
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