Journal ArticleDOI
Tracing the cellular origin of cancer
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TLDR
This review explores how mouse genetic lineage-tracing experiments that allow the expression of oncogenes and/or the deletion of tumour suppressor genes in defined cell lineages have been instrumental in defining the cellular origin of different solid tumours in mouse models for various human cancers.Abstract:
Although many genes that lead to different types of cancer when mutated have been identified, the cells that initiate tumour formation following accumulation of these mutations have, until recently, remained elusive. This review explores how mouse genetic lineage-tracing experiments that allow the expression of oncogenes and/or the deletion of tumour suppressor genes in defined cell lineages have been instrumental in defining the cellular origin of different solid tumours in mouse models for various human cancers.read more
Citations
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Linc-RNA-RoR acts as a "sponge" against mediation of the differentiation of endometrial cancer stem cells by microRNA-145.
TL;DR: It is suggested that linc-RoR has an important role during endometrial carcinogenesis as a ceRNA and acts as a miR-145 "sponge" to inhibit mediation of the differentiation of ETs by mi R-145.
Journal ArticleDOI
Metabolic pathways regulating colorectal cancer initiation and progression
TL;DR: Key findings implicating cancer metabolism as a major contributor of tumor initiation, growth and metastatic dissemination in CRC are reviewed and how some of these metabolic pathways could represent new vulnerabilities of CRC cells with the potential to be targeted are discussed.
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Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition
Mathilde Latil,Dany Nassar,Benjamin Beck,Soufiane Boumahdi,Li Wang,Audrey Brisebarre,Christine Dubois,Erwin Nkusi,Sandrine Lenglez,Agnieszka Checinska,Alizée Vercauteren Drubbel,Michael Devos,Wim Declercq,Rui Yi,Cédric Blanpain +14 more
TL;DR: Transcriptional and epigenomic profiling revealed that IFE and HF tumor-initiating cells possess distinct chromatin landscapes and gene regulatory networks associated with tumorigenesis and EMT that correlate with accessibility of key epithelial and E MT transcription factor binding sites.
Journal ArticleDOI
Colorectal carcinogenesis--update and perspectives.
TL;DR: The genetic and molecular knowledge of CRC has widen the scientific and clinical perspectives of diagnosing and treatment, however, despite significant advances in the understanding and treatment of CRC, results from targeted therapy are still not convincing.
Journal ArticleDOI
The Immune System in Cancer Pathogenesis: Potential Therapeutic Approaches.
TL;DR: This review highlights the fundamentals of incorporating precision medicine to discover new immune biomarkers and predictive signatures and suggests a personalized approach may have a significant, positive impact on the use of oncolytics to better guide safer and more effective therapies.
References
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Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
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Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.
TL;DR: The results for 20 world regions are presented, summarizing the global patterns for the eight most common cancers, and striking differences in the patterns of cancer from region to region are observed.
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Lessons from Hereditary Colorectal Cancer
TL;DR: The authors are grateful to the members of their laboratories for their contributions to the reviewed studies and to F. Giardiello and S. Hamilton for photographs of colorectal lesions.
Journal ArticleDOI
Identification of stem cells in small intestine and colon by marker gene Lgr5
Nick Barker,Johan H. van Es,Jeroen Kuipers,Pekka Kujala,Maaike van den Born,Miranda Cozijnsen,Andrea Haegebarth,Jeroen Korving,Harry Begthel,Peter J. Peters,Hans Clevers +10 more
TL;DR: The expression pattern of Lgr5 suggests that it marks stem cells in multiple adult tissues and cancers, suggesting that it represents the stem cell of the small intestine and colon.